| Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies NS Nielsen, ET Poulsen, MV Lukassen, CC Shern, EH Mogensen, ... Progress in Retinal and Eye Research 77, 100843, 2020 | 40 | 2020 |
| Proteomic profiling of TGFBI‐null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI‐linked corneal dystrophies ET Poulsen, K Runager, NS Nielsen, MV Lukassen, K Thomsen, P Snider, ... The FEBS journal 285 (1), 101-114, 2018 | 29 | 2018 |
| Proteomic investigation of cultivated fibroblasts from patients with mitochondrial short-chain acyl-CoA dehydrogenase deficiency AV Edhager, V Stenbroen, NS Nielsen, P Bross, RKJ Olsen, N Gregersen, ... Molecular genetics and metabolism 111 (3), 360-368, 2014 | 29 | 2014 |
| Structural and functional implications of human transforming growth factor β-induced protein, TGFBIp, in corneal dystrophies R García-Castellanos, NS Nielsen, K Runager, IB Thøgersen, ... Structure 25 (11), 1740-1750. e2, 2017 | 28 | 2017 |
| Fibril core of transforming growth factor beta-induced protein (TGFBIp) facilitates aggregation of corneal TGFBIp CS Sørensen, K Runager, C Scavenius, MM Jensen, NS Nielsen, ... Biochemistry 54 (19), 2943-2956, 2015 | 24 | 2015 |
| LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta‐induced protein … ET Poulsen, NS Nielsen, MM Jensen, E Nielsen, J Hjortdal, EK Kim, ... Proteomics 16 (3), 539-543, 2016 | 21 | 2016 |
| The serine protease HtrA1 cleaves misfolded transforming growth factor β–induced protein (TGFBIp) and induces amyloid formation ET Poulsen, NS Nielsen, C Scavenius, EH Mogensen, MW Risør, ... Journal of Biological Chemistry 294 (31), 11817-11828, 2019 | 16 | 2019 |
| Insight into the protein composition of immunoglobulin light chain deposits of eyelid, orbital and conjunctival amyloidosis NS Nielsen, ET Poulsen, GK Klintworth, JJ Enghild Journal of proteomics & bioinformatics, 2014 | 14 | 2014 |
| Development of selective protease inhibitors via engineering of the bait region of human α2-macroglobulin SL Harwood, NS Nielsen, K Diep, KT Jensen, PK Nielsen, K Yamamoto, ... Journal of Biological Chemistry 297 (1), 2021 | 10 | 2021 |
| Substituting the thiol ester of human A2M or C3 with a disulfide produces native proteins with altered proteolysis-induced conformational changes SL Harwood, NS Nielsen, H Pedersen, K Kjøge, PK Nielsen, ... Biochemistry 59 (51), 4799-4809, 2020 | 9 | 2020 |
| Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family NS Nielsen, A Zarantonello, SL Harwood, KT Jensen, K Kjøge, ... Nature Communications 13 (1), 3033, 2022 | 7 | 2022 |
| α2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester SL Harwood, NS Nielsen, KT Jensen, PK Nielsen, IB Thøgersen, ... Journal of Biological Chemistry 295 (49), 16732-16742, 2020 | 7 | 2020 |
| Periostin C-terminal is intrinsically disordered and interacts with 143 proteins in an in vitro epidermal model of atopic dermatitis CE Rusbjerg-Weberskov, ML Johansen, JS Nowak, DE Otzen, ... Biochemistry 62 (19), 2803-2815, 2023 | 6 | 2023 |
| Mutation-Induced Deamidation of Corneal Dystrophy-Related Transforming Growth Factor β-Induced Protein NS Nielsen, DW Juhl, ET Poulsen, MV Lukassen, EC Poulsen, MW Risør, ... Biochemistry 56 (49), 6470-6480, 2017 | 6 | 2017 |
| Mutation-induced dimerization of transforming growth factor-β–induced protein may drive protein aggregation in granular corneal dystrophy NS Nielsen, TAF Gadeberg, ET Poulsen, SL Harwood, CE Weberskov, ... Journal of Biological Chemistry 297 (1), 2021 | 3 | 2021 |
| The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel SL Harwood, K Diep, NS Nielsen, KT Jensen, JJ Enghild Journal of Biological Chemistry 298 (8), 2022 | 1 | 2022 |
| Processing of TGFBIp by HtrA1 in relation to corneal dystrophies NS Nielsen, ET Poulsen, MV Lukassen, IB Thøgersen, MW Risør, ... Investigative Ophthalmology & Visual Science 57 (12), 4912-4912, 2016 | 1 | 2016 |
| Mapping the Periostin splice isoforms in atopic dermatitis and an in vitro asthma model–A multi-platform analysis using mass spectrometry and RT-qPCR CE Rusbjerg-Weberskov, AK Hollensen, CK Damgaard, MB Løvendorf, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1872 (5), 141031, 2024 | | 2024 |
| Development of a top-down MS assay for specific identification of human periostin isoforms CE Rusbjerg-Weberskov, MS Gant, J Chamot-Rooke, NS Nielsen, ... Frontiers in Molecular Biosciences 11, 1399225, 2024 | | 2024 |
| Proteolytic cleavage of the TGF β co‐receptor CD 109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the … KT Jensen, NS Nielsen, A Viana Almeida, IB Thøgersen, JJ Enghild, ... The FEBS Journal, 2024 | | 2024 |
