| Efficacies of cabotegravir and bictegravir against drug-resistant HIV-1 integrase mutants SJ Smith, XZ Zhao, TR Burke, SH Hughes Retrovirology 15, 1-18, 2018 | 112 | 2018 |
| Structural basis for strand-transfer inhibitor binding to HIV intasomes DO Passos, M Li, IK Jóźwik, XZ Zhao, D Santos-Martins, R Yang, SJ Smith, ... Science 367 (6479), 810-814, 2020 | 88 | 2020 |
| Crystallographic and functional analysis of the ESCRT-I/HIV-1 Gag PTAP interaction YJ Im, L Kuo, X Ren, PV Burgos, XZ Zhao, F Liu, TR Burke, JS Bonifacino, ... Structure 18 (11), 1536-1547, 2010 | 84 | 2010 |
| Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets X Lu, U Nowicka, V Sridharan, F Liu, L Randles, D Hymel, M Dyba, ... Nature communications 8 (1), 15540, 2017 | 78 | 2017 |
| 4-amino-1-hydroxy-2-oxo-1, 8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1 XZ Zhao, SJ Smith, M Métifiot, C Marchand, PL Boyer, Y Pommier, ... Journal of Medicinal Chemistry 57 (12), 5190-5202, 2014 | 68 | 2014 |
| 2, 3-Dihydro-6, 7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors XZ Zhao, EA Semenova, BC Vu, K Maddali, C Marchand, SH Hughes, ... Journal of medicinal chemistry 51 (2), 251-259, 2008 | 65 | 2008 |
| Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality XZ Zhao, K Maddali, C Marchand, Y Pommier, TR Burke Jr Bioorganic & medicinal chemistry 17 (14), 5318-5324, 2009 | 57 | 2009 |
| Integrase strand transfer inhibitors are effective anti-HIV drugs SJ Smith, XZ Zhao, DO Passos, D Lyumkis, TR Burke Jr, SH Hughes Viruses 13 (2), 205, 2021 | 52 | 2021 |
| HIV-1 integrase inhibitors that are broadly effective against drug-resistant mutants SJ Smith, XZ Zhao, TR Burke Jr, SH Hughes Antimicrobial Agents and Chemotherapy 62 (9), 10.1128/aac. 01035-18, 2018 | 48* | 2018 |
| Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1H-isoindole Derivatives, Inhibitors of HIV-1 Integrase M Métifiot, K Maddali, BC Johnson, S Hare, SJ Smith, XZ Zhao, ... ACS chemical biology 8 (1), 209-217, 2013 | 47 | 2013 |
| Structure-guided optimization of HIV integrase strand transfer inhibitors XZ Zhao, SJ Smith, DP Maskell, M Métifiot, VE Pye, K Fesen, C Marchand, ... Journal of medicinal chemistry 60 (17), 7315-7332, 2017 | 46 | 2017 |
| HIV-1 integrase strand transfer inhibitors with reduced susceptibility to drug resistant mutant integrases XZ Zhao, SJ Smith, DP Maskell, M Metifiot, VE Pye, K Fesen, C Marchand, ... ACS chemical biology 11 (4), 1074-1081, 2016 | 46 | 2016 |
| Bicyclic 1-hydroxy-2-oxo-1, 2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant … XZ Zhao, SJ Smith, M Métifiot, BC Johnson, C Marchand, Y Pommier, ... Journal of Medicinal Chemistry 57 (4), 1573-1582, 2014 | 46 | 2014 |
| Developing and evaluating inhibitors against the RNase H active site of HIV-1 reverse transcriptase PL Boyer, SJ Smith, XZ Zhao, K Das, K Gruber, E Arnold, TR Burke Jr, ... Journal of virology 92 (13), 10.1128/jvi. 02203-17, 2018 | 44 | 2018 |
| Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2, 3-dihydro-6, 7-dihydroxy-1H-isoindol-1-ones and 4, 5-dihydroxy-1H-isoindole-1, 3 (2H … XZ Zhao, K Maddali, BC Vu, C Marchand, SH Hughes, Y Pommier, ... Bioorganic & medicinal chemistry letters 19 (10), 2714-2717, 2009 | 41 | 2009 |
| MK-0536 inhibits HIV-1 integrases resistant to raltegravir M Métifiot, B Johnson, S Smith, XZ Zhao, C Marchand, T Burke, S Hughes, ... Antimicrobial agents and chemotherapy 55 (11), 5127-5133, 2011 | 40 | 2011 |
| A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals YX Jia, X Li, B Wu, XZ Zhao, YQ Tu Tetrahedron 58 (9), 1697-1708, 2002 | 38 | 2002 |
| Bicyclic Hydroxy‐1H‐pyrrolopyridine‐trione Containing HIV‐1 Integrase Inhibitors XZ Zhao, K Maddali, M Metifiot, SJ Smith, BC Vu, C Marchand, ... Chemical biology & drug design 79 (2), 157-165, 2012 | 36 | 2012 |
| HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses Z Yan, KF Bryant, SM Gregory, M Angelova, DH Dreyfus, XZ Zhao, ... MBio 5 (4), 10.1128/mbio. 01318-14, 2014 | 33 | 2014 |
| Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors XZ Zhao, K Maddali, M Metifiot, SJ Smith, BC Vu, C Marchand, ... Bioorganic & medicinal chemistry letters 21 (10), 2986-2990, 2011 | 32 | 2011 |
