| The genetic code is one in a million SJ Freeland, LD Hurst Journal of molecular evolution 47, 238-248, 1998 | 623 | 1998 |
| Rewiring the keyboard: evolvability of the genetic code RD Knight, SJ Freeland, LF Landweber Nature Reviews Genetics 2 (1), 49-58, 2001 | 526 | 2001 |
| A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes RD Knight, SJ Freeland, LF Landweber Genome biology 2, 1-13, 2001 | 497 | 2001 |
| Selection, history and chemistry: the three faces of the genetic code RD Knight, SJ Freeland, LF Landweber Trends in biochemical sciences 24 (6), 241-247, 1999 | 310 | 1999 |
| Early fixation of an optimal genetic code SJ Freeland, RD Knight, LF Landweber, LD Hurst Molecular biology and evolution 17 (4), 511-518, 2000 | 292 | 2000 |
| The case for an error minimizing standard genetic code SJ Freeland, T Wu, N Keulmann Origins of Life and Evolution of the Biosphere 33, 457-477, 2003 | 157 | 2003 |
| Do proteins predate DNA? SJ Freeland, RD Knight, LF Landweber Science 286 (5440), 690-692, 1999 | 120 | 1999 |
| The synthetic gene designer: a flexible web platform to explore sequence manipulation for heterologous expression G Wu, N Bashir-Bello, SJ Freeland Protein expression and purification 47 (2), 441-445, 2006 | 107 | 2006 |
| On the evolution of the standard amino-acid alphabet Y Lu, S Freeland Genome biology 7, 1-6, 2006 | 99 | 2006 |
| Testing a biosynthetic theory of the genetic code: fact or artifact? TA Ronneberg, LF Landweber, SJ Freeland Proceedings of the National Academy of Sciences 97 (25), 13690-13695, 2000 | 93 | 2000 |
| Simplified gene synthesis: a one-step approach to PCR-based gene construction G Wu, JB Wolf, AF Ibrahim, S Vadasz, M Gunasinghe, SJ Freeland Journal of biotechnology 124 (3), 496-503, 2006 | 90 | 2006 |
| Did evolution select a nonrandom “alphabet” of amino acids? GK Philip, SJ Freeland Astrobiology 11 (3), 235-240, 2011 | 83 | 2011 |
| Extraordinarily adaptive properties of the genetically encoded amino acids M Ilardo, M Meringer, S Freeland, B Rasulev, HJ Cleaves II Scientific reports 5 (1), 9414, 2015 | 80 | 2015 |
| Load minimization of the genetic code: history does not explain the pattern SJ Freeland, LD Hurst Proceedings of the Royal Society of London. Series B: Biological Sciences …, 1998 | 79 | 1998 |
| Fitness of the cosmos for life: Biochemistry and fine-tuning JD Barrow Cambridge University Press, 2008 | 74 | 2008 |
| The Darwinian genetic code: an adaptation for adapting? SJ Freeland Genetic Programming and Evolvable Machines 3, 113-127, 2002 | 67 | 2002 |
| Beyond terrestrial biology: Charting the chemical universe of α-amino acid structures M Meringer, HJ Cleaves, SJ Freeland Journal of chemical information and modeling 53 (11), 2851-2862, 2013 | 57 | 2013 |
| Measuring adaptation within the genetic code SJ Freeland, RD Knight, LF Landweber Trends in biochemical sciences 25 (2), 44-45, 2000 | 57 | 2000 |
| The standard genetic code enhances adaptive evolution of proteins W Zhu, S Freeland Journal of theoretical biology 239 (1), 63-70, 2006 | 50 | 2006 |
| SGDB: a database of synthetic genes re-designed for optimizing protein over-expression G Wu, Y Zheng, I Qureshi, HT Zin, T Beck, B Bulka, SJ Freeland Nucleic acids research 35 (suppl_1), D76-D79, 2007 | 49 | 2007 |
