Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor P Pelegrin, A Surprenant The EMBO journal 25 (21), 5071-5082, 2006 | 1723 | 2006 |
The gasdermins, a protein family executing cell death and inflammation P Broz, P Pelegrín, F Shao Nature Reviews Immunology 20 (3), 143-157, 2020 | 1029 | 2020 |
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response A Baroja-Mazo, F Martín-Sánchez, AI Gomez, CM Martínez, ... Nature immunology 15 (8), 738-748, 2014 | 852 | 2014 |
P2X7 receptor differentially couples to distinct release pathways for IL-1β in mouse macrophage P Pelegrin, C Barroso-Gutierrez, A Surprenant The Journal of Immunology 180 (11), 7147-7157, 2008 | 487 | 2008 |
Cell volume regulation modulates NLRP3 inflammasome activation V Compan, A Baroja-Mazo, G López-Castejón, AI Gomez, CM Martínez, ... Immunity 37 (3), 487-500, 2012 | 427 | 2012 |
Pannexin-1 couples to maitotoxin-and nigericin-induced interleukin-1β release through a dye uptake-independent pathway P Pelegrin, A Surprenant Journal of Biological Chemistry 282 (4), 2386-2394, 2007 | 384 | 2007 |
Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis S Gaul, A Leszczynska, F Alegre, B Kaufmann, CD Johnson, LA Adams, ... Journal of hepatology 74 (1), 156-167, 2021 | 343 | 2021 |
MCC950 closes the active conformation of NLRP3 to an inactive state A Tapia-Abellán, D Angosto-Bazarra, H Martínez-Banaclocha, ... Nature chemical biology 15 (6), 560-564, 2019 | 331 | 2019 |
Pharmacological characterization of pannexin-1 currents expressed in mammalian cells W Ma, H Hui, P Pelegrin, A Surprenant Journal of Pharmacology and Experimental Therapeutics 328 (2), 409-418, 2009 | 327 | 2009 |
Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense J Garaude, R Acín-Pérez, S Martínez-Cano, M Enamorado, M Ugolini, ... Nature immunology 17 (9), 1037-1045, 2016 | 295 | 2016 |
Dynamics of macrophage polarization reveal new mechanism to inhibit IL‐1β release through pyrophosphates P Pelegrin, A Surprenant The EMBO journal 28 (14), 2114-2127, 2009 | 292 | 2009 |
NLRP3 and pyroptosis blockers for treating inflammatory diseases RC Coll, K Schroder, P Pelegrín Trends in pharmacological sciences 43 (8), 653-668, 2022 | 280 | 2022 |
Inflammasome-dependent IL-1β release depends upon membrane permeabilisation F Martín-Sánchez, C Diamond, M Zeitler, AI Gomez, A Baroja-Mazo, ... Cell Death & Differentiation 23 (7), 1219-1231, 2016 | 270 | 2016 |
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 A Denes, G Coutts, N Lénárt, SM Cruickshank, P Pelegrin, J Skinner, ... Proceedings of the National Academy of Sciences 112 (13), 4050-4055, 2015 | 265 | 2015 |
The participation of plasma membrane hemichannels to purinergic signaling A Baroja-Mazo, M Barberà-Cremades, P Pelegrín Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (1), 79-93, 2013 | 242 | 2013 |
The NLRP3 and pyrin inflammasomes: implications in the pathophysiology of autoinflammatory diseases C de Torre-Minguela, P Mesa del Castillo, P Pelegrín Frontiers in immunology 8, 246244, 2017 | 226 | 2017 |
P2X7 receptor activation enhances SK3 channels-and cystein cathepsin-dependent cancer cells invasiveness B Jelassi, A Chantome, F Alcaraz-Perez, A Baroja-Mazo, ML Cayuela, ... Oncogene 30 (18), 2108-2122, 2011 | 224 | 2011 |
The P2X7 receptor–pannexin connection to dye uptake and IL-1β release P Pelegrin, A Surprenant Purinergic signalling 5, 129-137, 2009 | 201 | 2009 |
Inflammasomes in liver fibrosis F Alegre, P Pelegrin, AE Feldstein Seminars in liver disease 37 (02), 119-127, 2017 | 194 | 2017 |
P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis JJ Martínez-García, H Martínez-Banaclocha, D Angosto-Bazarra, ... Nature communications 10 (1), 2711, 2019 | 187 | 2019 |