| SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon … BA Malcolm, R Liu, F Lahser, S Agrawal, B Belanger, N Butkiewicz, ... Antimicrobial agents and chemotherapy 50 (3), 1013-1020, 2006 | 390 | 2006 |
| Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3 … S Venkatraman, SL Bogen, A Arasappan, F Bennett, K Chen, E Jao, ... Journal of medicinal chemistry 49 (20), 6074-6086, 2006 | 319 | 2006 |
| On the mechanism of the Skraup− Doebner− Von Miller quinoline synthesis SE Denmark, S Venkatraman The Journal of Organic Chemistry 71 (4), 1668-1676, 2006 | 254 | 2006 |
| Novel Tricyclic Inhibitors of Farnesyl Protein Transferase: BIOCHEMICAL CHARACTERIZATION AND INHIBITION OF Ras MODIFICATION IN TRANSFECTED Cos CELLS (∗) WR Bishop, R Bond, J Petrin, L Wang, R Patton, R Doll, G Njoroge, ... Journal of Biological Chemistry 270 (51), 30611-30618, 1995 | 229 | 1995 |
| Peptides as NS3-serine protease inhibitors of hepatitis C virus AK Saksena, VM Girijavallabhan, RG Lovey, E Jao, F Bennett, ... US Patent 7,012,066, 2006 | 214 | 2006 |
| Oxazoles: synthesis, reactions, and spectroscopy DC Palmer Wiley, 2003 | 186* | 2003 |
| An improved protocol for azole synthesis with PEG-supported Burgess reagent P Wipf, S Venkatraman Tetrahedron letters 37 (27), 4659-4662, 1996 | 143 | 1996 |
| A New Thiazole Synthesis by Cyclocondensation of Thioamides and Alkynyl (Aryl) Iodonium Reagents. P Wipf, S Venkatraman The Journal of Organic Chemistry 61 (23), 8004-8005, 1996 | 127 | 1996 |
| Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl … AJ Prongay, Z Guo, N Yao, J Pichardo, T Fischmann, C Strickland, ... Journal of medicinal chemistry 50 (10), 2310-2318, 2007 | 125 | 2007 |
| Thiolysis of oxazolines: A new, selective method for the direct conversion of peptide oxazolines into thiazolines P Wipf, CP Miller, S Venkatraman, PC Fritch Tetrahedron letters 36 (36), 6395-6398, 1995 | 124 | 1995 |
| Discovery of narlaprevir (SCH 900518): a potent, second generation HCV NS3 serine protease inhibitor A Arasappan, F Bennett, SL Bogen, S Venkatraman, M Blackman, ... ACS medicinal chemistry letters 1 (2), 64-69, 2010 | 104 | 2010 |
| Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties S Venkatraman, KX Chen, A Arasappan, FG Njoroge, VM Girijavallabhan, ... US Patent 6,914,122, 2005 | 98 | 2005 |
| From aziridines to oxazolines and thiazolines: The heterocyclic route to thiangazole P Wipf, S Venkatraman Synlett 1 (01), 1-10, 1997 | 96 | 1997 |
| Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising N-cyclic P2 moieties KX Chen, A Arasappan, S Venkatraman, T Parekh, H Gu, GF Njoroge, ... US Patent 6,846,802, 2005 | 92 | 2005 |
| Total synthesis of (−)-muscoride A P Wipf, S Venkatraman The Journal of Organic Chemistry 61 (19), 6517-6522, 1996 | 87 | 1996 |
| Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication SL Bogen, A Arasappan, F Bennett, K Chen, E Jao, YT Liu, RG Lovey, ... Journal of medicinal chemistry 49 (9), 2750-2757, 2006 | 80 | 2006 |
| Total Synthesis of (-)-Thiangazole and Structurally Related Polyazoles P Wipf, S Venkatraman The Journal of Organic Chemistry 60 (22), 7224-7229, 1995 | 78 | 1995 |
| (1R, 2S, 5S)-N-[(1S)-3-amino-1-(cyclobutylmethyl)-2, 3-dioxopropyl]-3-[(2S)-2-[[[(1, 1-dimethylethyl) amino] carbonyl] amino]-3, 3-dimethyl-1-oxobutyl]-6, 6-dimethyl-3 … F Njoroge, S Venkatraman US Patent App. 11/121,433, 2005 | 75 | 2005 |
| Discovery of boceprevir, a direct-acting NS3/4A protease inhibitor for treatment of chronic hepatitis C infections S Venkatraman Trends in pharmacological sciences 33 (5), 289-294, 2012 | 74 | 2012 |
| 3, 4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease FG Njoroge, S Venkatraman, A Arasappan, F Velazquez, ... US Patent 7,342,041, 2008 | 73 | 2008 |
