| Differential regulation of CYP3A4 and CYP3A5 and its implication in drug discovery O Lolodi, YM Wang, WC Wright, T Chen Current drug metabolism 18 (12), 1095-1105, 2017 | 102 | 2017 |
| The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma M Pan, WC Wright, RH Chapple, A Zubair, M Sandhu, JE Batchelder, ... Nature communications 12 (1), 6468, 2021 | 54 | 2021 |
| Structural perspectives of the CYP3A family and their small molecule modulators in drug metabolism WC Wright, J Chenge, T Chen Liver research 3 (3-4), 132-142, 2019 | 46 | 2019 |
| Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer SC Chai, WC Wright, T Chen Medicinal research reviews 40 (3), 1061-1083, 2020 | 37 | 2020 |
| Clobetasol propionate is a heme-mediated selective inhibitor of human cytochrome P450 3A5 WC Wright, J Chenge, J Wang, HM Girvan, L Yang, SC Chai, AD Huber, ... Journal of medicinal chemistry 63 (3), 1415-1433, 2020 | 37 | 2020 |
| Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells J Bakke, WC Wright, AE Zamora, P Oladimeji, JC Crawford, CT Brewer, ... BMC cancer 19, 1-12, 2019 | 28 | 2019 |
| Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning AD Huber, WC Wright, W Lin, K Majumder, JA Low, J Wu, CD Buchman, ... Cellular and Molecular Life Sciences 78, 317-335, 2021 | 26 | 2021 |
| CINPA1 binds directly to constitutive androstane receptor and inhibits its activity MT Cherian, SC Chai, WC Wright, A Singh, MA Casal, J Zheng, J Wu, ... Biochemical pharmacology 152, 211-223, 2018 | 23 | 2018 |
| Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation MN Bwayi, E Garcia-Maldonado, SC Chai, B Xie, S Chodankar, AD Huber, ... Nucleic acids research 50 (6), 3254-3275, 2022 | 18 | 2022 |
| Discovery and characterization of the antimetabolite action of thioacetamide-linked 1, 2, 3-triazoles as disruptors of cysteine biosynthesis in gram-negative bacteria MJ Wallace, S Dharuman, DM Fernando, SM Reeve, CT Gee, J Yao, ... ACS infectious diseases 6 (3), 467-478, 2019 | 18 | 2019 |
| Building a chemical toolbox for human pregnane X receptor research: discovery of agonists, inverse agonists, and antagonists among analogs based on the unique chemical scaffold … Y Li, W Lin, WC Wright, SC Chai, J Wu, T Chen Journal of medicinal chemistry 64 (3), 1733-1761, 2021 | 16 | 2021 |
| Unraveling the structural basis of selective inhibition of human cytochrome P450 3A5 J Wang, CD Buchman, J Seetharaman, DJ Miller, AD Huber, J Wu, ... Journal of the American Chemical Society 143 (44), 18467-18480, 2021 | 13 | 2021 |
| Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia JL Kamens, S Nance, C Koss, B Xu, A Cotton, JW Lam, EAR Garfinkle, ... nature communications 14 (1), 809, 2023 | 10 | 2023 |
| Cell type identification in spatial transcriptomics data can be improved by leveraging cell-type-informative paired tissue images using a Bayesian probabilistic model A Zubair, RH Chapple, S Natarajan, WC Wright, M Pan, HM Lee, ... Nucleic Acids Research 50 (14), e80-e80, 2022 | 10 | 2022 |
| KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion PO Oladimeji, J Bakke, WC Wright, T Chen Scientific reports 10 (1), 1485, 2020 | 10 | 2020 |
| RNA interference screen identifies NAA10 as a regulator of PXR transcription PO Oladimeji, WC Wright, J Wu, T Chen Biochemical pharmacology 160, 92-109, 2019 | 8 | 2019 |
| Transcription factor ZNF148 is a negative regulator of human muscle differentiation J Bakke, WC Wright, AE Zamora, SS Ong, YM Wang, JD Hoyer, ... Scientific Reports 7 (1), 8138, 2017 | 8 | 2017 |
| A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics HM Lee, WC Wright, M Pan, J Low, D Currier, J Fang, S Singh, S Nance, ... Nature Communications 14 (1), 7332, 2023 | 3 | 2023 |
| Jointly leveraging spatial transcriptomics and deep learning models for image annotation achieves better-than-pathologist performance in cell type identification in tumors A Zubair, R Chapple, S Natarajan, WC Wright, M Pan, HM Lee, H Tillman, ... Cancer Research 82 (12_Supplement), 456-456, 2022 | 2 | 2022 |
| Reprocessing of RNA-sequencing samples from publicly-available data to yield normalized and comparable expression results. WC Wright, T Chen | 1 | 2019 |
