Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species C Changtam, HP de Koning, H Ibrahim, MS Sajid, MK Gould, ... European journal of medicinal chemistry 45 (3), 941-956, 2010 | 221 | 2010 |
Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes DJ Bridges, MK Gould, B Nerima, P Mäser, RJS Burchmore, ... Molecular pharmacology 71 (4), 1098-1108, 2007 | 153 | 2007 |
Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes S Dean, MK Gould, CE Dewar, AC Schnaufer Proceedings of the National Academy of Sciences 110 (36), 14741-14746, 2013 | 127 | 2013 |
New drugs for human African trypanosomiasis: a twenty first century success story EA Dickie, F Giordani, MK Gould, P Mäser, C Burri, JC Mottram, SPS Rao, ... Tropical medicine and infectious disease 5 (1), 29, 2020 | 109 | 2020 |
Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets HP de Koning, MK Gould, GJ Sterk, H Tenor, S Kunz, E Luginbuehl, ... Journal of infectious diseases 206 (2), 229-237, 2012 | 105 | 2012 |
Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: comparison with the Alamar Blue assay MK Gould, XL Vu, T Seebeck, HP de Koning Analytical biochemistry 382 (2), 87-93, 2008 | 93 | 2008 |
Cyclic-nucleotide signalling in protozoa MK Gould, HP de Koning FEMS microbiology reviews 35 (3), 515-541, 2011 | 69 | 2011 |
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA MK Gould, S Bachmaier, JAM Ali, S Alsford, DNA Tagoe, JC Munday, ... Antimicrobial agents and chemotherapy 57 (10), 4882-4893, 2013 | 65 | 2013 |
2,N6-Disubstituted Adenosine Analogs with Antitrypanosomal and Antimalarial Activities B Rodenko, AM van der Burg, MJ Wanner, M Kaiser, R Brun, M Gould, ... Antimicrobial agents and chemotherapy 51 (11), 3796-3802, 2007 | 61 | 2007 |
Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei CE Dewar, P MacGregor, S Cooper, MK Gould, KR Matthews, NJ Savill, ... PLoS pathogens 14 (7), e1007195, 2018 | 50 | 2018 |
Molecular interactions underlying the unusually high adenosine affinity of a novel Trypanosoma brucei nucleoside transporter MI Al-Salabi, LJM Wallace, A Lüscher, P Mäser, D Candlish, B Rodenko, ... Molecular pharmacology 71 (3), 921-929, 2007 | 46 | 2007 |
Reduced mitochondrial membrane potential Is a late adaptation of Trypanosoma brucei brucei to isometamidium preceded by mutations in the γ subunit of the F1Fo-ATPase AA Eze, MK Gould, JC Munday, DNA Tagoe, V Stelmanis, A Schnaufer, ... PLoS neglected tropical diseases 10 (8), e0004791, 2016 | 39 | 2016 |
Independence from Kinetoplast DNA Maintenance and Expression Is Associated with Multidrug Resistance in Trypanosoma brucei In Vitro MK Gould, A Schnaufer Antimicrobial agents and chemotherapy 58 (5), 2925-2928, 2014 | 28 | 2014 |
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections SPS Rao, MK Gould, J Noeske, M Saldivia, RS Jumani, PS Ng, O René, ... Science 380 (6652), 1349-1356, 2023 | 16 | 2023 |
A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission S Bachmaier, G Giacomelli, E Calvo-Alvarez, LR Vieira, ... Nature Communications 13 (1), 5445, 2022 | 15 | 2022 |
PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast JS Grewal, K McLuskey, D Das, E Myburgh, J Wilkes, E Brown, ... Journal of Biological Chemistry 291 (18), 9492-9500, 2016 | 15 | 2016 |
The effects of exogenous gonadotropins on ovarian adenylate cyclase activity CL NUGENT, A Lopata, MK Gould Endocrinology 97 (3), 581-587, 1975 | 12 | 1975 |
Mä ser P, Burchmore RJS, De Koning HP: Loss of the high affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine … D Bridges, MK Gould, B Nerima Mol Pharmacol 71, 1098-1108, 2007 | 7 | 2007 |
Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei S Bachmaier, MK Gould, E Polatoglou, R Omelianczyk, AE Brennand, ... Frontiers in Cellular and Infection Microbiology 13, 1204707, 2023 | 6 | 2023 |
Independence from Kinetoplast DNA MK Gould, A Schnaufer | | 2014 |