| Ustekinumab as induction and maintenance therapy for ulcerative colitis BE Sands, WJ Sandborn, R Panaccione, CD O’Brien, H Zhang, J Johanns, ... New England Journal of Medicine 381 (13), 1201-1214, 2019 | 1014 | 2019 |
| Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis N Kamada, T Hisamatsu, S Okamoto, H Chinen, T Kobayashi, T Sato, ... The Journal of clinical investigation 118 (6), 2269-2280, 2008 | 851 | 2008 |
| CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells T Hisamatsu, M Suzuki, HC Reinecker, WJ Nadeau, BA McCormick, ... Gastroenterology 124 (4), 993-1000, 2003 | 825 | 2003 |
| IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease T Kobayashi, S Okamoto, T Hisamatsu, N Kamada, H Chinen, R Saito, ... Gut 57 (12), 1682-1689, 2008 | 722 | 2008 |
| Evidence-based clinical practice guidelines for inflammatory bowel disease 2020 H Nakase, M Uchino, S Shinzaki, M Matsuura, K Matsuoka, T Kobayashi, ... Journal of gastroenterology 56 (6), 489-526, 2021 | 329 | 2021 |
| A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice A Hayashi, T Sato, N Kamada, Y Mikami, K Matsuoka, T Hisamatsu, T Hibi, ... Cell host & microbe 13 (6), 711-722, 2013 | 311 | 2013 |
| Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS … M Suzuki, T Hisamatsu, DK Podolsky Infection and immunity 71 (6), 3503-3511, 2003 | 291 | 2003 |
| Imbalance of NKp44+ NKp46− and NKp44− NKp46+ natural killer cells in the intestinal mucosa of patients with Crohn's disease T Takayama, N Kamada, H Chinen, S Okamoto, MT Kitazume, J Chang, ... Gastroenterology 139 (3), 882-892. e3, 2010 | 271 | 2010 |
| Adalimumab monotherapy and a combination with azathioprine for Crohn’s disease: a prospective, randomized trial T Matsumoto, S Motoya, K Watanabe, T Hisamatsu, H Nakase, ... Journal of Crohn's and Colitis 10 (11), 1259-1266, 2016 | 269 | 2016 |
| Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria N Kamada, T Hisamatsu, S Okamoto, T Sato, K Matsuoka, K Arai, T Nakai, ... The Journal of Immunology 175 (10), 6900-6908, 2005 | 267 | 2005 |
| Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients K Matsuoka, Y Iwao, T Mori, A Sakuraba, T Yajima, T Hisamatsu, ... Official journal of the American College of Gastroenterology| ACG 102 (2 …, 2007 | 253 | 2007 |
| Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials G d'Haens, R Panaccione, F Baert, P Bossuyt, JF Colombel, S Danese, ... The Lancet 399 (10340), 2015-2030, 2022 | 214 | 2022 |
| Novel, objective, multivariate biomarkers composed of plasma amino acid profiles for the diagnosis and assessment of inflammatory bowel disease T Hisamatsu, S Okamoto, M Hashimoto, T Muramatsu, A Andou, M Uo, ... PloS one 7 (1), e31131, 2012 | 198 | 2012 |
| Efficacy of indigo naturalis in a multicenter randomized controlled trial of patients with ulcerative colitis M Naganuma, S Sugimoto, K Mitsuyama, T Kobayashi, N Yoshimura, ... Gastroenterology 154 (4), 935-947, 2018 | 191 | 2018 |
| TGR5 signalling inhibits the production of pro‐inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease K Yoneno, T Hisamatsu, K Shimamura, N Kamada, R Ichikawa, ... Immunology 139 (1), 19-29, 2013 | 188 | 2013 |
| T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn’s disease K Matsuoka, N Inoue, T Sato, S Okamoto, T Hisamatsu, Y Kishi, ... Gut 53 (9), 1303-1308, 2004 | 187 | 2004 |
| GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells N Barnich, T Hisamatsu, JE Aguirre, R Xavier, HC Reinecker, ... Journal of Biological Chemistry 280 (19), 19021-19026, 2005 | 184 | 2005 |
| Risankizumab as maintenance therapy for moderately to severely active Crohn's disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal … M Ferrante, R Panaccione, F Baert, P Bossuyt, JF Colombel, S Danese, ... The Lancet 399 (10340), 2031-2046, 2022 | 176 | 2022 |
| Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages A Andou, T Hisamatsu, S Okamoto, H Chinen, N Kamada, T Kobayashi, ... Gastroenterology 136 (2), 564-574. e2, 2009 | 169 | 2009 |
| Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10–producing regulatory macrophage subset Y Takada, T Hisamatsu, N Kamada, MT Kitazume, H Honda, Y Oshima, ... The Journal of Immunology 184 (5), 2671-2676, 2010 | 162 | 2010 |
