| Structural insight into catalytic mechanism of PET hydrolase X Han, W Liu, JW Huang, J Ma, Y Zheng, TP Ko, L Xu, YS Cheng, ... Nature communications 8 (1), 2106, 2017 | 436 | 2017 |
| Enzymatic degradation of plant biomass and synthetic polymers CC Chen, L Dai, L Ma, RT Guo Nature Reviews Chemistry 4 (3), 114-126, 2020 | 288 | 2020 |
| Multitarget drug discovery for tuberculosis and other infectious diseases K Li, LA Schurig-Briccio, X Feng, A Upadhyay, V Pujari, B Lechartier, ... Journal of medicinal chemistry 57 (7), 3126-3139, 2014 | 255 | 2014 |
| Bisphosphonates target multiple sites in both cis-and trans-prenyltransferases RT Guo, R Cao, PH Liang, TP Ko, TH Chang, MP Hudock, WY Jeng, ... Proceedings of the National Academy of Sciences 104 (24), 10022-10027, 2007 | 223 | 2007 |
| Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation Y Zhang, R Cao, F Yin, MP Hudock, RT Guo, K Krysiak, S Mukherjee, ... Journal of the American Chemical Society 131 (14), 5153-5162, 2009 | 208 | 2009 |
| Structural studies reveal the molecular mechanism of PET ase CC Chen, X Han, TP Ko, W Liu, RT Guo The FEBS journal 285 (20), 3717-3723, 2018 | 152 | 2018 |
| Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and … RT Guo, TP Ko, APC Chen, CJ Kuo, AHJ Wang, PH Liang Journal of Biological Chemistry 280 (21), 20762-20774, 2005 | 146 | 2005 |
| Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis HM Chu, RT Guo, TW Lin, CC Chou, HL Shr, HL Lai, TY Tang, KJ Cheng, ... Structure 12 (11), 2015-2024, 2004 | 139 | 2004 |
| General features to enhance enzymatic activity of poly (ethylene terephthalate) hydrolysis CC Chen, X Han, X Li, P Jiang, D Niu, L Ma, W Liu, S Li, Y Qu, H Hu, ... Nature Catalysis 4 (5), 425-430, 2021 | 132 | 2021 |
| A structural change in butyrophilin upon phosphoantigen binding underlies phosphoantigen-mediated Vγ9Vδ2 T cell activation Y Yang, L Li, L Yuan, X Zhou, J Duan, H Xiao, N Cai, S Han, X Ma, W Liu, ... Immunity 50 (4), 1043-1053. e5, 2019 | 119 | 2019 |
| Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination TH Chang, RT Guo, TP Ko, AHJ Wang, PH Liang Journal of Biological Chemistry 281 (21), 14991-15000, 2006 | 111 | 2006 |
| Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis RT Guo, YE Chong, M Guo, XL Yang Journal of Biological Chemistry 284 (42), 28968-28976, 2009 | 94 | 2009 |
| Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation MP Hudock, Y Zhang, RT Guo, R Cao, JH No, PH Liang, TP Ko, ... Journal of medicinal chemistry 51 (18), 5594-5607, 2008 | 94 | 2008 |
| Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis WY Jeng, TP Ko, CI Liu, RT Guo, CL Liu, HL Shr, AHJ Wang Nucleic acids research 36 (5), 1567-1577, 2008 | 89 | 2008 |
| Recognition of double-stranded RNA and regulation of interferon pathway by toll-like receptor 10 SMY Lee, TF Yip, S Yan, DY Jin, HL Wei, RT Guo, JSM Peiris Frontiers in Immunology 9, 516, 2018 | 86 | 2018 |
| Squalene synthase as a target for Chagas disease therapeutics N Shang, Q Li, TP Ko, HC Chan, J Li, Y Zheng, CH Huang, F Ren, ... PLoS pathogens 10 (5), e1004114, 2014 | 86 | 2014 |
| Crystal structures of d-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars HC Chan, Y Zhu, Y Hu, TP Ko, CH Huang, F Ren, CC Chen, Y Ma, ... Protein & cell 3, 123-131, 2012 | 84 | 2012 |
| Efficient reductive desymmetrization of bulky 1, 3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase X Chen, H Zhang, MA Maria-Solano, W Liu, J Li, J Feng, X Liu, S Osuna, ... Nature Catalysis 2 (10), 931-941, 2019 | 82 | 2019 |
| Structural analysis of a glycoside hydrolase family 11 xylanase from Neocallimastix patriciarum: insights into the molecular basis of a thermophilic enzyme YS Cheng, CC Chen, CH Huang, TP Ko, W Luo, JW Huang, JR Liu, ... Journal of Biological Chemistry 289 (16), 11020-11028, 2014 | 82 | 2014 |
| KRAS (G12D) can be targeted by potent inhibitors via formation of salt bridge Z Mao, H Xiao, P Shen, Y Yang, J Xue, Y Yang, Y Shang, L Zhang, X Li, ... Cell discovery 8 (1), 5, 2022 | 81 | 2022 |
