| Structure of a modular polyketide synthase S Dutta, JR Whicher, DA Hansen, WA Hale, JA Chemler, GR Congdon, ... Nature 510 (7506), 512-517, 2014 | 388 | 2014 |
| Metabolic engineering for plant natural product biosynthesis in microbes JA Chemler, MAG Koffas Current opinion in biotechnology 19 (6), 597-605, 2008 | 253 | 2008 |
| Improving NADPH availability for natural product biosynthesis in Escherichia coli by metabolic engineering JA Chemler, ZL Fowler, KP McHugh, MAG Koffas Metabolic engineering 12 (2), 96-104, 2010 | 243 | 2010 |
| Structural rearrangements of a polyketide synthase module during its catalytic cycle JR Whicher, S Dutta, DA Hansen, WA Hale, JA Chemler, AM Dosey, ... Nature 510 (7506), 560-564, 2014 | 226 | 2014 |
| Metabolic Engineering of Anthocyanin Biosynthesis in Escherichia coli Y Yan, J Chemler, L Huang, S Martens, MAG Koffas Applied and environmental microbiology 71 (7), 3617-3623, 2005 | 188 | 2005 |
| Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae JA Chemler, Y Yan, MAG Koffas Microbial Cell Factories 5, 1-9, 2006 | 162 | 2006 |
| Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli E Leonard, J Chemler, KH Lim, MAG Koffas Applied microbiology and biotechnology 70, 85-91, 2006 | 111 | 2006 |
| Standardized biosynthesis of flavan-3-ols with effects on pancreatic beta-cell insulin secretion JA Chemler, LT Lock, MAG Koffas, ES Tzanakakis Applied Microbiology and Biotechnology 77, 797-807, 2007 | 98 | 2007 |
| Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C H Functionalization AN Lowell, MD DeMars, ST Slocum, F Yu, K Anand, JA Chemler, ... Journal of the American Chemical Society 139 (23), 7913-7920, 2017 | 87 | 2017 |
| Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering I Koryakina, C Kasey, JB McArthur, AN Lowell, JA Chemler, S Li, ... ACS chemical biology 12 (1), 114-123, 2017 | 80 | 2017 |
| Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor JA Chemler, TJ Buchholz, TW Geders, DL Akey, CM Rath, GE Chlipala, ... Journal of the American Chemical Society 134 (17), 7359-7366, 2012 | 72 | 2012 |
| Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms JA Chemler, Y Yan, E Leonard, MAG Koffas Organic letters 9 (10), 1855-1858, 2007 | 69 | 2007 |
| Evolution of efficient modular polyketide synthases by homologous recombination JA Chemler, A Tripathi, DA Hansen, M O’Neil-Johnson, RB Williams, ... Journal of the American Chemical Society 137 (33), 10603-10609, 2015 | 51 | 2015 |
| A versatile microbial system for biosynthesis of novel polyphenols with altered estrogen receptor binding activity JA Chemler, CG Lim, JL Daiss, MAG Koffas Chemistry & biology 17 (4), 392-401, 2010 | 40 | 2010 |
| Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS SA Bonnett, CM Rath, AR Shareef, JR Joels, JA Chemler, K Håkansson, ... Chemistry & biology 18 (9), 1075-1081, 2011 | 38 | 2011 |
| Characterization of dihydroflavonol 4-reductases for recombinant plant pigment biosynthesis applications E Leonard, Y Yan, J Chemler, U Matern, S Martens, MAG Koffas Biocatalysis and Biotransformation 26 (3), 243-251, 2008 | 32 | 2008 |
| A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster KJ McDonnell, JA Chemler, PL Bartels, E O’Brien, ML Marvin, J Ortega, ... Nature chemistry 10 (8), 873-880, 2018 | 25 | 2018 |
| Natural product bis-intercalator depsipeptides as a new class of payloads for antibody–drug conjugates AS Ratnayake, L Chang, LN Tumey, F Loganzo, JA Chemler, ... Bioconjugate Chemistry 30 (1), 200-209, 2018 | 17 | 2018 |
| Flavonoid biotransformations in microorganisms JA Chemler, E Leonard, MAG Koffas Anthocyanins: Biosynthesis, Functions, and Applications, 191-255, 2009 | 16 | 2009 |
| Probing selectivity and creating structural diversity through hybrid polyketide synthases AA Koch, JJ Schmidt, AN Lowell, DA Hansen, KM Coburn, JA Chemler, ... Angewandte Chemie 132 (32), 13677-13682, 2020 | 14 | 2020 |
