ID-Score: a new empirical scoring function based on a comprehensive set of descriptors related to protein–ligand interactions GB Li, LL Yang, WJ Wang, LL Li, SY Yang Journal of chemical information and modeling 53 (3), 592-600, 2013 | 175 | 2013 |
Heterocyclic-fused pyrimidines as novel tubulin polymerization inhibitors targeting the colchicine binding site: structural basis and antitumor efficacy S Banerjee, KE Arnst, Y Wang, G Kumar, S Deng, L Yang, G Li, J Yang, ... Journal of medicinal chemistry 61 (4), 1704-1718, 2018 | 77 | 2018 |
Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway S Zhang, M Yu, Q Guo, R Li, G Li, S Tan, X Li, Y Wei, M Wu Scientific reports 5 (1), 15859, 2015 | 76 | 2015 |
New techniques and strategies in drug discovery J Du, J Guo, D Kang, Z Li, G Wang, J Wu, Z Zhang, H Fang, X Hou, ... Chinese Chemical Letters 31 (7), 1695-1708, 2020 | 70 | 2020 |
Real-time bioluminescence imaging of nitroreductase in mouse model P Feng, H Zhang, Q Deng, W Liu, L Yang, G Li, G Chen, L Du, B Ke, M Li Analytical chemistry 88 (11), 5610-5614, 2016 | 68 | 2016 |
NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors GB Li, MI Abboud, J Brem, H Someya, CT Lohans, SY Yang, J Spencer, ... Chemical Science 8 (2), 928-937, 2017 | 67 | 2017 |
Mechanism of microtubule stabilization by taccalonolide AJ Y Wang, Y Yu, GB Li, SA Li, C Wu, B Gigant, W Qin, H Chen, Y Wu, ... Nature communications 8 (1), 15787, 2017 | 64 | 2017 |
Structure–Activity Relationship Studies of Pyrazolo[3,4-d]pyrimidine Derivatives Leading to the Discovery of a Novel Multikinase Inhibitor That Potently Inhibits FLT3 … LL Yang, GB Li, S Ma, C Zou, S Zhou, QZ Sun, C Cheng, X Chen, ... Journal of medicinal chemistry 56 (4), 1641-1655, 2013 | 64 | 2013 |
Discovery of N6-phenyl-1H-pyrazolo [3, 4-d] pyrimidine-3, 6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit … LL Yang, GB Li, HX Yan, QZ Sun, S Ma, P Ji, ZR Wang, S Feng, J Zou, ... European journal of medicinal chemistry 56, 30-38, 2012 | 56 | 2012 |
Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors L Yang, X Ma, Y He, C Yuan, Q Chen, G Li, X Chen Science China Life Sciences 60, 249-256, 2017 | 55 | 2017 |
((S)-3-Mercapto-2-methylpropanamido) acetic acid derivatives as metallo-β-lactamase inhibitors: synthesis, kinetic and crystallographic studies S Liu, L Jing, ZJ Yu, C Wu, Y Zheng, E Zhang, Q Chen, Y Yu, L Guo, Y Wu, ... European Journal of Medicinal Chemistry 145, 649-660, 2018 | 47 | 2018 |
Discovery and preliminary structure–activity relationship of 1H-indazoles with promising indoleamine-2, 3-dioxygenase 1 (IDO1) inhibition properties S Qian, T He, W Wang, Y He, M Zhang, L Yang, G Li, Z Wang Bioorganic & Medicinal Chemistry 24 (23), 6194-6205, 2016 | 42 | 2016 |
Design, Synthesis, and Structure–Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src … CH Zhang, MW Zheng, YP Li, XD Lin, M Huang, L Zhong, GB Li, ... Journal of medicinal chemistry 58 (9), 3957-3974, 2015 | 42 | 2015 |
Visible light photoredox catalyzed thiophosphate synthesis using methylene blue as a promoter H Zhang, Z Zhan, Y Lin, Y Shi, G Li, Q Wang, Y Deng, L Hai, Y Wu Organic Chemistry Frontiers 5 (9), 1416-1422, 2018 | 38 | 2018 |
YLT192, a novel, orally active bioavailable inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy in preclinical models Y Xia, X Song, D Li, T Ye, Y Xu, H Lin, N Meng, G Li, S Deng, S Zhang, ... Scientific reports 4 (1), 6031, 2014 | 36 | 2014 |
Principles and current strategies targeting metallo‐β‐lactamase mediated antibacterial resistance YH Yan, G Li, GB Li Medicinal Research Reviews 40 (5), 1558-1592, 2020 | 34 | 2020 |
Structure-based development of (1-(3′-mercaptopropanamido) methyl) boronic acid derived broad-spectrum, dual-action inhibitors of metallo-and serine-β-lactamases YL Wang, S Liu, ZJ Yu, Y Lei, MY Huang, YH Yan, Q Ma, Y Zheng, ... Journal of Medicinal Chemistry 62 (15), 7160-7184, 2019 | 34 | 2019 |
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells LL Yang, HL Wang, L Zhong, C Yuan, SY Liu, ZJ Yu, S Liu, YH Yan, C Wu, ... European journal of medicinal chemistry 155, 806-823, 2018 | 34 | 2018 |
SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo Y Xia, Q Lei, Y Zhu, T Ye, N Wang, G Li, X Shi, Y Liu, B Shao, T Yin, ... Cancer letters 355 (2), 297-309, 2014 | 34 | 2014 |
Discovery of 2-((4, 6-dimethylpyrimidin-2-yl) thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors L Yang, X Ma, C Yuan, Y He, L Li, S Fang, W Xia, T He, S Qian, Z Xu, G Li, ... European Journal of Medicinal Chemistry 134, 230-241, 2017 | 33 | 2017 |