Calibration of ionic and cellular cardiac electrophysiology models DG Whittaker, M Clerx, CL Lei, DJ Christini, GR Mirams Wiley Interdisciplinary Reviews: Systems Biology and Medicine 12 (4), e1482, 2020 | 94 | 2020 |
Emerging therapeutic targets in the short QT syndrome JC Hancox, DG Whittaker, C Du, AG Stuart, H Zhang Expert opinion on therapeutic targets 22 (5), 439-451, 2018 | 53 | 2018 |
Considering discrepancy when calibrating a mechanistic electrophysiology model CL Lei, S Ghosh, DG Whittaker, Y Aboelkassem, KA Beattie, CD Cantwell, ... Philosophical Transactions of the Royal Society A 378 (2173), 20190349, 2020 | 51 | 2020 |
Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments CL Lei, M Clerx, DG Whittaker, DJ Gavaghan, TP de Boer, GR Mirams Philosophical Transactions of the Royal Society A 378 (2173), 20190348, 2020 | 50 | 2020 |
Synergistic anti-arrhythmic effects in human atria with combined use of sodium blockers and acacetin H Ni, DG Whittaker, W Wang, WR Giles, SM Narayan, H Zhang Frontiers in Physiology 8, 946, 2017 | 40 | 2017 |
Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles DG Whittaker, H Ni, AP Benson, JC Hancox, H Zhang Frontiers in physiology 8, 759, 2017 | 37 | 2017 |
Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria DG Whittaker, H Ni, A El Harchi, JC Hancox, H Zhang PLoS Computational Biology 13 (6), e1005593, 2017 | 31 | 2017 |
Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling DG Whittaker, MA Colman, H Ni, JC Hancox, H Zhang Frontiers in physiology 9, 1402, 2018 | 30 | 2018 |
In silico investigation of a KCNQ1 mutation associated with short QT syndrome I Adeniran, DG Whittaker, A El Harchi, JC Hancox, H Zhang Scientific reports 7 (1), 8469, 2017 | 26 | 2017 |
Multi-scale approaches for the simulation of cardiac electrophysiology: II–Tissue-level structure and function AP Benson, HJ Stevenson-Cocks, DG Whittaker, E White, MA Colman Methods 185, 60-81, 2021 | 17 | 2021 |
In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome DG Whittaker, JC Hancox, H Zhang Frontiers in physiology 9, 1888, 2019 | 15 | 2019 |
Multi-scale approaches for the simulation of cardiac electrophysiology: I–Sub-cellular and stochastic calcium dynamics from cell to organ MA Colman, M Holmes, DG Whittaker, I Jayasinghe, AP Benson Methods 185, 49-59, 2021 | 13 | 2021 |
Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243 JM Kemp, DG Whittaker, R Venkateshappa, ZK Pang, R Johal, V Sergeev, ... Journal of General Physiology 153 (10), e202112923, 2021 | 12 | 2021 |
Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine DG Whittaker, RA Capel, M Hendrix, XHS Chan, N Herring, NJ White, ... Royal Society Open Science 8 (4), 210235, 2021 | 10 | 2021 |
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer CL Lei, A Fabbri, DG Whittaker, M Clerx, MJ Windley, AP Hill, GR Mirams, ... Wellcome Open Research 5, 2020 | 10 | 2020 |
Effects of Heart Rate and Ventricular Wall Thickness on Non-invasive Mapping: An in silico Study EA Perez Alday, DG Whittaker, AP Benson, MA Colman Frontiers in physiology 10, 308, 2019 | 10 | 2019 |
Investigation of the role of myocyte orientations in cardiac arrhythmia using image-based models DG Whittaker, AP Benson, I Teh, JE Schneider, MA Colman Biophysical Journal 117 (12), 2396-2408, 2019 | 9 | 2019 |
The short QT syndrome JC Hancox, MJ McPate, A El Harchi, AS Butler, Y Zhang, DG Whittaker, ... Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation and …, 2023 | 8 | 2023 |
Learning from studying very rare cardiac conditions: the example of short QT syndrome JC Hancox, DG Whittaker, H Zhang, AG Stuart Journal of Congenital Cardiology 3, 1-15, 2019 | 8 | 2019 |
Calibration of ionic and cellular cardiac electrophysiology models. Wires Syst Biol Med 12 (4): e1482 DG Whittaker, M Clerx, CL Lei, DJ Christini, GR Mirams | 5 | 2020 |