| β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors M Azzi, PG Charest, S Angers, G Rousseau, T Kohout, M Bouvier, ... Proceedings of the National Academy of Sciences 100 (20), 11406-11411, 2003 | 643 | 2003 |
| The regulation of cell motility and chemotaxis by phospholipid signaling V Kolsch, PG Charest, RA Firtel Journal of cell science 121 (5), 551-559, 2008 | 443 | 2008 |
| Big roles for small GTPases in the control of directed cell movement PG Charest, RA Firtel Biochemical Journal 401 (2), 377-390, 2007 | 269 | 2007 |
| G protein–independent Ras/PI3K/F-actin circuit regulates basic cell motility AT Sasaki, C Janetopoulos, S Lee, PG Charest, K Takeda, ... The Journal of cell biology 178 (2), 185-191, 2007 | 256 | 2007 |
| Monitoring agonist‐promoted conformational changes of β‐arrestin in living cells by intramolecular BRET PG Charest, S Terrillon, M Bouvier EMBO reports 6 (4), 334-340, 2005 | 210 | 2005 |
| Real-time monitoring of ubiquitination in living cells by BRET J Perroy, S Pontier, PG Charest, M Aubry, M Bouvier Nature Methods 1 (3), 203-208, 2004 | 198 | 2004 |
| A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration PG Charest, Z Shen, A Lakoduk, AT Sasaki, SP Briggs, RA Firtel Developmental cell 18 (5), 737-749, 2010 | 187 | 2010 |
| Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway K Takeda, D Shao, M Adler, PG Charest, WF Loomis, H Levine, ... Science signaling 5 (205), ra2-ra2, 2012 | 178 | 2012 |
| Feedback signaling controls leading-edge formation during chemotaxis PG Charest, RA Firtel Current opinion in genetics & development 16 (4), 339-347, 2006 | 175 | 2006 |
| Spatiotemporal regulation of Ras activity provides directional sensing S Zhang, PG Charest, RA Firtel Current Biology 18 (20), 1587-1593, 2008 | 135 | 2008 |
| Palmitoylation of the V2 vasopressin receptor carboxyl tail enhances β-arrestin recruitment leading to efficient receptor endocytosis and ERK1/2 activation PG Charest, M Bouvier Journal of Biological Chemistry 278 (42), 41541-41551, 2003 | 108 | 2003 |
| The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signalling PG Charest, G Oligny-Longpré, H Bonin, M Azzi, M Bouvier Cellular signalling 19 (1), 32-41, 2007 | 98 | 2007 |
| Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between β-arrestins and AP-2 FF Hamdan, MD Rochdi, B Breton, D Fessart, DE Michaud, PG Charest, ... Journal of Biological Chemistry 282 (40), 29089-29100, 2007 | 95 | 2007 |
| Activated membrane patches guide chemotactic cell motility I Hecht, ML Skoge, PG Charest, E Ben-Jacob, RA Firtel, WF Loomis, ... PLoS computational biology 7 (6), e1002044, 2011 | 86 | 2011 |
| The small GTPases Ras and Rap1 bind to and control TORC2 activity A Khanna, P Lotfi, AJ Chavan, NM Montaño, P Bolourani, G Weeks, ... Scientific reports 6 (1), 25823, 2016 | 58 | 2016 |
| Ras, PI3K and mTORC2–three's a crowd? SF Smith, SE Collins, PG Charest Journal of cell science 133 (19), jcs234930, 2020 | 28 | 2020 |
| Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility V Kölsch, Z Shen, S Lee, K Plak, P Lotfi, J Chang, PG Charest, JL Romero, ... Molecular biology of the cell 24 (2), 100-114, 2013 | 25 | 2013 |
| Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors AFM Tariqul Islam, M Scavello, P Lotfi, D Daniel, P Haldeman, ... Molecular and cellular biochemistry 457, 157-168, 2019 | 16 | 2019 |
| Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium M Scavello, AR Petlick, R Ramesh, VF Thompson, P Lotfi, PG Charest Journal of Cell Science 130 (9), 1545-1558, 2017 | 16 | 2017 |
| Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis K Sumita, H Yoshino, M Sasaki, N Majd, ER Kahoud, H Takahashi, ... Journal of Biological Chemistry 289 (7), 3950-3959, 2014 | 9 | 2014 |
