RNA-guided human genome engineering via Cas9 P Mali, L Yang, KM Esvelt, J Aach, M Guell, JE DiCarlo, JE Norville, ... Science 339 (6121), 823-826, 2013 | 11504 | 2013 |
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering P Mali, J Aach, PB Stranges, KM Esvelt, M Moosburner, S Kosuri, L Yang, ... Nature biotechnology 31 (9), 833-838, 2013 | 2279 | 2013 |
Cas9 as a versatile tool for engineering biology P Mali, KM Esvelt, GM Church Nature methods 10 (10), 957-963, 2013 | 1723 | 2013 |
Heritable genome editing in C. elegans via a CRISPR-Cas9 system AE Friedland, YB Tzur, KM Esvelt, MP Colaiácovo, GM Church, ... Nature methods 10 (8), 741-743, 2013 | 1151 | 2013 |
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing KM Esvelt, P Mali, JL Braff, M Moosburner, SJ Yaung, GM Church Nature methods 10 (11), 1116-1121, 2013 | 1078 | 2013 |
Concerning RNA-Guided Gene Drives for the Alteration of Wild Populations KM Esvelt, AL Smidler, F Catteruccia, GM Church eLife, 10.7554/eLife.03401, 2014 | 908 | 2014 |
A system for the continuous directed evolution of biomolecules KM Esvelt, JC Carlson, DR Liu Nature 472 (7344), 499-503, 2011 | 827 | 2011 |
Genome‐scale engineering for systems and synthetic biology KM Esvelt, HH Wang Molecular systems biology 9 (1), 641, 2013 | 443 | 2013 |
Regulating gene drives KA Oye, K Esvelt, E Appleton, F Catteruccia, G Church, T Kuiken, ... Science 345 (6197), 626-628, 2014 | 427 | 2014 |
Safeguarding CRISPR-Cas9 gene drives in yeast JE DiCarlo, A Chavez, SL Dietz, KM Esvelt, GM Church Nature biotechnology 33 (12), 1250-1255, 2015 | 403 | 2015 |
Low-N protein engineering with data-efficient deep learning S Biswas, G Khimulya, EC Alley, KM Esvelt, GM Church Nature methods 18 (4), 389-396, 2021 | 356 | 2021 |
Safeguarding gene drive experiments in the laboratory OS Akbari, HJ Bellen, E Bier, SL Bullock, A Burt, GM Church, KR Cook, ... Science 349 (6251), 927-929, 2015 | 347 | 2015 |
Daisy-chain gene drives for the alteration of local populations C Noble, J Min, J Olejarz, J Buchthal, A Chavez, AL Smidler, ... Proceedings of the National Academy of Sciences 116 (17), 8275-8282, 2019 | 242 | 2019 |
Evolutionary dynamics of CRISPR gene drives C Noble, J Olejarz, KM Esvelt, GM Church, MA Nowak Science advances 3 (4), e1601964, 2017 | 202 | 2017 |
Conservation demands safe gene drive KM Esvelt, NJ Gemmell PLoS biology 15 (11), e2003850, 2017 | 201 | 2017 |
RNA-Guided Transcriptional Regulation GM Church, KM Esvelt US Patent App. 14/319,530, 2014 | 198 | 2014 |
RNA-guided transcriptional regulation GM Church, KM Esvelt US Patent 9,267,135, 2016 | 191 | 2016 |
Current CRISPR gene drive systems are likely to be highly invasive in wild populations C Noble, B Adlam, GM Church, KM Esvelt, MA Nowak Elife 7, e33423, 2018 | 174 | 2018 |
Bidirectional contact tracing could dramatically improve COVID-19 control WJ Bradshaw, EC Alley, JH Huggins, AL Lloyd, KM Esvelt Nature communications 12 (1), 232, 2021 | 148 | 2021 |
Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution BC Dickinson, AM Leconte, B Allen, KM Esvelt, DR Liu Proceedings of the National Academy of Sciences 110 (22), 9007-9012, 2013 | 135 | 2013 |