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Dr. Ahmad Al-Khliefat
Dr. Ahmad Al-Khliefat
在 kcl.ac.uk 的电子邮件经过验证
标题
引用次数
引用次数
年份
Detection of long repeat expansions from PCR-free whole-genome sequence data
E Dolzhenko, JJ Van Vugt, RJ Shaw, MA Bekritsky, M Van Blitterswijk, ...
Genome research 27 (11), 1895-1903, 2017
3272017
A multicentre validation study of the diagnostic value of plasma neurofilament light
NJ Ashton, S Janelidze, A Al Khleifat, A Leuzy, EL van der Ende, ...
Nature communications 12 (1), 3400, 2021
2962021
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
W Van Rheenen, RAA Van Der Spek, MK Bakker, JJFA Van Vugt, PJ Hop, ...
Nature genetics 53 (12), 1636-1648, 2021
2942021
Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study
T Fang, A Al Khleifat, JH Meurgey, A Jones, PN Leigh, G Bensimon, ...
The Lancet Neurology 17 (5), 416-422, 2018
2542018
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
JL Min, G Hemani, E Hannon, KF Dekkers, J Castillo-Fernandez, R Luijk, ...
Nature genetics 53 (9), 1311-1321, 2021
2412021
Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis
European Journal of Human Genetics 26 (10), 1537-1546, 2018
1362018
What causes amyotrophic lateral sclerosis?
S Martin, A Al Khleifat, A Al-Chalabi
F1000Research 6, 2017
1272017
Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein
SMK Farhan, DP Howrigan, LE Abbott, JR Klim, SD Topp, AE Byrnes, ...
Nature neuroscience 22 (12), 1966-1974, 2019
1162019
C9orf72 intermediate expansions of 24–30 repeats are associated with ALS
A Iacoangeli, A Al Khleifat, AR Jones, W Sproviero, A Shatunov, ...
Acta neuropathologica communications 7, 1-7, 2019
1052019
A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK
S Morgan, A Shatunov, W Sproviero, AR Jones, M Shoai, D Hughes, ...
Brain 140 (6), 1611-1618, 2017
982017
Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial
N Riva, G Mora, G Sorarù, C Lunetta, OE Ferraro, Y Falzone, L Leocani, ...
The Lancet Neurology 18 (2), 155-164, 2019
952019
Comparison of the King’s and MiToS staging systems for ALS
T Fang, A Al Khleifat, DR Stahl, C Lazo La Torre, C Murphy, ...
Amyotrophic lateral sclerosis and frontotemporal degeneration 18 (3-4), 227-232, 2017
902017
Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias
PR Mehta, AR Jones, S Opie-Martin, A Shatunov, A Iacoangeli, ...
Journal of Neurology, Neurosurgery & Psychiatry 90 (3), 268-271, 2019
632019
Association of variants in the SPTLC1 gene with juvenile amyotrophic lateral sclerosis
JO Johnson, R Chia, DE Miller, R Li, R Kumaran, Y Abramzon, ...
JAMA neurology 78 (10), 1236-1248, 2021
602021
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
PJ Hop, RAJ Zwamborn, E Hannon, GL Shireby, MF Nabais, EM Walker, ...
Science translational medicine 14 (633), eabj0264, 2022
522022
Genome-wide meta-analysis finds the ACSL5-ZDHHC6 locus is associated with ALS and links weight loss to the disease genetics
A Iacoangeli, T Lin, A Al Khleifat, AR Jones, S Opie-Martin, JRI Coleman, ...
Cell Reports 33 (4), 2020
502020
A standard operating procedure for King’s ALS clinical staging
R Balendra, A Al Khleifat, T Fang, A Al-Chalabi
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20 (3-4), 159-164, 2019
452019
Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis
A Al Khleifat, A Iacoangeli, JJFA Van Vugt, H Bowles, M Moisse, ...
NPJ genomic medicine 7 (1), 8, 2022
352022
The impact of age on genetic testing decisions in amyotrophic lateral sclerosis
PR Mehta, A Iacoangeli, S Opie-Martin, JJFA van Vugt, A Al Khleifat, ...
Brain 145 (12), 4440-4447, 2022
282022
Whole-genome sequencing reveals that variants in the interleukin 18 receptor accessory protein 3′ UTR protect against ALS
C Eitan, A Siany, E Barkan, T Olender, KR van Eijk, M Moisse, ...
Nature neuroscience 25 (4), 433-445, 2022
272022
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