| Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor A Vannini, C Volpari, G Filocamo, EC Casavola, M Brunetti, D Renzoni, ... Proceedings of the National Academy of Sciences 101 (42), 15064-15069, 2004 | 785 | 2004 |
| HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics P Gallinari, SD Marco, P Jones, M Pallaoro, C Steinkühler Cell research 17 (3), 195-211, 2007 | 714 | 2007 |
| Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases A Lahm, C Paolini, M Pallaoro, MC Nardi, P Jones, P Neddermann, ... Proceedings of the National Academy of Sciences 104 (44), 17335-17340, 2007 | 612 | 2007 |
| Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation G Canettieri, L Di Marcotullio, A Greco, S Coni, L Antonucci, P Infante, ... Nature cell biology 12 (2), 132-142, 2010 | 381 | 2010 |
| Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors GC Minetti, C Colussi, R Adami, C Serra, C Mozzetta, V Parente, S Fortuni, ... Nature medicine 12 (10), 1147-1150, 2006 | 367 | 2006 |
| Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain MJ Bottomley, PL Surdo, P Di Giovine, A Cirillo, R Scarpelli, F Ferrigno, ... Journal of Biological Chemistry 283 (39), 26694-26704, 2008 | 364 | 2008 |
| Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 Å resolution structure in a hexagonal crystal form Y Yan, Y Li, S Munshi, V Sardana, JL Cole, M Sardana, LC Kuo, Z Chen, ... Protein Science 7 (4), 837-847, 1998 | 351 | 1998 |
| Product inhibition of the hepatitis C virus NS3 protease C Steinkühler, G Biasiol, M Brunetti, A Urbani, U Koch, R Cortese, A Pessi, ... Biochemistry 37 (25), 8899-8905, 1998 | 312 | 1998 |
| Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex A Vannini, C Volpari, P Gallinari, P Jones, M Mattu, A Carfí, ... EMBO reports 8 (9), 879-884, 2007 | 302 | 2007 |
| HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment C Colussi, C Mozzetta, A Gurtner, B Illi, J Rosati, S Straino, G Ragone, ... Proceedings of the National Academy of Sciences 105 (49), 19183-19187, 2008 | 269 | 2008 |
| Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus P Gallinari, D Brennan, C Nardi, M Brunetti, L Tomei, C Steinkühler, ... Journal of virology 72 (8), 6758-6769, 1998 | 260 | 1998 |
| Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products P Ingallinella, S Altamura, E Bianchi, M Taliani, R Ingenito, R Cortese, ... Biochemistry 37 (25), 8906-8914, 1998 | 249 | 1998 |
| A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease F Narjes, KF Koehler, U Koch, B Gerlach, S Colarusso, C Steinkühler, ... Bioorganic & medicinal chemistry letters 12 (4), 701-704, 2002 | 195 | 2002 |
| Activity of purified hepatitis C virus protease NS3 on peptide substrates C Steinkühler, A Urbani, L Tomei, G Biasiol, M Sardana, E Bianchi, ... Journal of virology 70 (10), 6694-6700, 1996 | 189 | 1996 |
| Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure P Gallo, MVG Latronico, P Gallo, S Grimaldi, F Borgia, M Todaro, P Jones, ... Cardiovascular research 80 (3), 416-424, 2008 | 175 | 2008 |
| A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates M Taliani, E Bianchi, F Narjes, M Fossatelli, A Urbani, C Steinkühler, ... Analytical biochemistry 240 (1), 60-67, 1996 | 168 | 1996 |
| In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor C Trozzi, L Bartholomew, A Ceccacci, G Biasiol, L Pacini, S Altamura, ... Journal of virology 77 (6), 3669-3679, 2003 | 160 | 2003 |
| PP2A regulates HDAC4 nuclear import G Paroni, N Cernotta, C Dello Russo, P Gallinari, M Pallaoro, C Foti, ... Molecular biology of the cell 19 (2), 655-667, 2008 | 146 | 2008 |
| The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism G Barbato, DO Cicero, MC Nardi, C SteinkuÈhler, R Cortese, ... Journal of molecular biology 289 (2), 371-384, 1999 | 143 | 1999 |
| Affinity selection of a camelized V (H) domain antibody inhibitor of hepatitis C virus NS3 protease. F Martin, C Volpari, C Steinkuhler, N Dimasi, M Brunetti, G Biasiol, ... Protein Engineering 10 (5), 607-614, 1997 | 140 | 1997 |
