| Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity O Werz, J Gerstmeier, S Libreros, X De la Rosa, M Werner, PC Norris, ... Nature communications 9 (1), 59, 2018 | 265 | 2018 |
| Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products NC Gilbert, J Gerstmeier, EE Schexnaydre, F Börner, U Garscha, ... Nature chemical biology 16 (7), 783-790, 2020 | 168 | 2020 |
| Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome M Werner, PM Jordan, E Romp, A Czapka, Z Rao, C Kretzer, A Koeberle, ... The FASEB Journal 33 (5), 6140, 2019 | 108 | 2019 |
| Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males S Pace, C Pergola, F Dehm, A Rossi, J Gerstmeier, F Troisi, H Pein, ... The Journal of clinical investigation 127 (8), 3167-3176, 2017 | 84 | 2017 |
| Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP) E Banoglu, B Çalışkan, S Luderer, G Eren, Y Özkan, W Altenhofen, ... Bioorganic & medicinal chemistry 20 (12), 3728-3741, 2012 | 68 | 2012 |
| Time‐resolved in situ assembly of the leukotriene‐synthetic 5‐lipoxygenase/5‐lipoxygenase‐activating protein complex in blood leukocytes J Gerstmeier, C Weinigel, S Rummler, O Rådmark, O Werz, U Garscha The FASEB Journal 30 (1), 276-285, 2016 | 59 | 2016 |
| Staphylococcus aureus-derived α-hemolysin evokes generation of specialized pro-resolving mediators promoting inflammation resolution PM Jordan, J Gerstmeier, S Pace, R Bilancia, Z Rao, F Börner, L Miek, ... Cell reports 33 (2), 2020 | 57 | 2020 |
| 4, 5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP) E Banoglu, E Çelikoğlu, S Völker, A Olgaç, J Gerstmeier, U Garscha, ... European Journal of Medicinal Chemistry 113, 1-10, 2016 | 54 | 2016 |
| The novel benzimidazole derivative BRP‐7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5‐lipoxygenase‐activating protein (FLAP) C Pergola, J Gerstmeier, B Mönch, B Çalışkan, S Luderer, C Weinigel, ... British journal of pharmacology 171 (12), 3051-3064, 2014 | 51 | 2014 |
| Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase U Garscha, E Romp, S Pace, A Rossi, V Temml, D Schuster, S König, ... Scientific reports 7 (1), 9398, 2017 | 45 | 2017 |
| Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents O Werz, J Gerstmeier, U Garscha Expert opinion on therapeutic patents 27 (5), 607-620, 2017 | 45 | 2017 |
| Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase L Thomas, Z Rao, J Gerstmeier, M Raasch, C Weinigel, S Rummler, ... Biochemical pharmacology 130, 71-82, 2017 | 44 | 2017 |
| An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis J Gerstmeier, C Weinigel, D Barz, O Werz, U Garscha Biochimica et Biophysica Acta (BBA)-General Subjects 1840 (9), 2961-2969, 2014 | 44 | 2014 |
| 5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation J Gerstmeier, ME Newcomer, S Dennhardt, E Romp, J Fischer, O Werz, ... The FASEB Journal 30 (5), 1892, 2016 | 42 | 2016 |
| BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly U Garscha, S Voelker, S Pace, J Gerstmeier, B Emini, S Liening, A Rossi, ... Biochemical pharmacology 119, 17-26, 2016 | 41 | 2016 |
| Imbricaric acid and perlatolic acid: Multi-targeting anti-inflammatory depsides from Cetrelia monachorum SK Oettl, J Gerstmeier, SY Khan, K Wiechmann, J Bauer, AG Atanasov, ... PLoS One 8 (10), e76929, 2013 | 41 | 2013 |
| Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening V Temml, U Garscha, E Romp, G Schubert, J Gerstmeier, Z Kutil, ... Scientific reports 7 (1), 42751, 2017 | 40 | 2017 |
| Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach M Napagoda, J Gerstmeier, S Wesely, S Popella, S Lorenz, K Scheubert, ... Journal of Ethnopharmacology 151 (2), 800-809, 2014 | 37 | 2014 |
| Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout M Napagoda, J Gerstmeier, H Butschek, S Lorenz, D Kanatiwela, ... Journal of ethnopharmacology 224, 474-481, 2018 | 36 | 2018 |
| Ginkgolic acid is a multi-target inhibitor of key enzymes in pro-inflammatory lipid mediator biosynthesis J Gerstmeier, J Seegers, F Witt, B Waltenberger, V Temml, JM Rollinger, ... Frontiers in pharmacology 10, 797, 2019 | 35 | 2019 |
