Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region–abelson (Bcr-Abl) kinase and overcomes … X Ren, X Pan, Z Zhang, D Wang, X Lu, Y Li, D Wen, H Long, J Luo, ... Journal of medicinal chemistry 56 (3), 879-894, 2013 | 146 | 2013 |
Nanoparticle‐conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses L Nuhn, S De Koker, S Van Lint, Z Zhong, JP Catani, F Combes, ... Advanced Materials 30 (45), 1803397, 2018 | 136 | 2018 |
Carcinogenic components of tobacco and tobacco smoke: A 2022 update Y Li, SS Hecht Food and Chemical Toxicology 165, 113179, 2022 | 114 | 2022 |
Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed Y Li, SS Hecht International journal of molecular sciences 23 (9), 4559, 2022 | 94 | 2022 |
Coumarin–benzimidazole hybrids: A review of developments in medicinal chemistry CG Arya, R Gondru, Y Li, J Banothu European journal of medicinal chemistry 227, 113921, 2022 | 78 | 2022 |
Small Molecule Discoidin Domain Receptor Kinase Inhibitors and Potential Medical Applications: Miniperspective Y Li, X Lu, X Ren, K Ding Journal of medicinal chemistry 58 (8), 3287-3301, 2015 | 73 | 2015 |
Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist L Nuhn, L Van Hoecke, K Deswarte, B Schepens, Y Li, BN Lambrecht, ... Biomaterials 178, 643-651, 2018 | 60 | 2018 |
Lymph-node-targeted immune activation by engineered block copolymer amphiphiles–TLR7/8 agonist conjugates S Van Herck, K Deswarte, L Nuhn, Z Zhong, JP Portela Catani, Y Li, ... Journal of the American Chemical Society 140 (43), 14300-14307, 2018 | 53 | 2018 |
Discovery of the first-in-class agonist-based SOS1 PROTACs effective in human cancer cells harboring various KRAS mutations C Zhou, Z Fan, Z Zhou, Y Li, R Cui, C Liu, G Zhou, X Diao, H Jiang, ... Journal of medicinal chemistry 65 (5), 3923-3942, 2022 | 48 | 2022 |
Design, synthesis, and biological evaluation of 3-(1 H-1, 2, 3-triazol-1-yl) benzamide derivatives as potent pan Bcr-Abl inhibitors including the threonine315→ isoleucine315 … Y Li, M Shen, Z Zhang, J Luo, X Pan, X Lu, H Long, D Wen, F Zhang, ... Journal of medicinal chemistry 55 (22), 10033-10046, 2012 | 45 | 2012 |
Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines Y Li, SS Hecht International journal of molecular sciences 23 (9), 5109, 2022 | 35 | 2022 |
Hyaluronic acid conjugates of TLR7/8 agonists for targeted delivery to secondary lymphoid tissue E Yoo, ACD Salyer, MJH Brush, Y Li, KL Trautman, NM Shukla, ... Bioconjugate chemistry 29 (8), 2741-2754, 2018 | 31 | 2018 |
Design, synthesis, and biological evaluation of novel EGFR PROTACs targeting Del19/T790M/C797S mutation H Zhang, R Xie, H Ai-Furas, Y Li, Q Wu, J Li, F Xu, T Xu ACS Medicinal Chemistry Letters 13 (2), 278-283, 2022 | 27 | 2022 |
Resolution and quantitation of mercapturic acids derived from crotonaldehyde, methacrolein, and methyl vinyl ketone in the urine of smokers and nonsmokers M Chen, SG Carmella, Y Li, Y Zhao, SS Hecht Chemical research in toxicology 33 (2), 669-677, 2020 | 17 | 2020 |
Discovery of a potent, cooperative, and selective SOS1 PROTAC ZZ151 with in vivo antitumor efficacy in KRAS-mutant cancers Z Zhou, G Zhou, C Zhou, Z Fan, R Cui, Y Li, R Li, Y Gu, H Li, Z Ge, X Cai, ... Journal of medicinal chemistry 66 (6), 4197-4214, 2023 | 15 | 2023 |
Design and Optimization of 3′-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors C Mo, Z Zhang, Y Li, M Huang, J Zou, J Luo, ZC Tu, Y Xu, X Ren, K Ding, ... ACS Medicinal Chemistry Letters 11 (3), 379-384, 2020 | 15 | 2020 |
Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine Y Li, B Ma, Q Cao, S Balbo, L Zhao, P Upadhyaya, SS Hecht Chemical research in toxicology 32 (4), 773-783, 2019 | 14 | 2019 |
Investigation of 2′-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N′-Nitrosonornicotine Metabolism Y Li, ES Carlson, AT Zarth, P Upadhyaya, SS Hecht Chemical research in toxicology 34 (4), 1004-1015, 2021 | 12 | 2021 |
Identification of an N′-Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA Y Li, SS Hecht Chemical research in toxicology 34 (4), 992-1003, 2021 | 12 | 2021 |
Ionizable drug delivery systems for efficient and selective gene therapy YQ Zhang, RR Guo, YH Chen, TC Li, WZ Du, RW Xiang, JB Guan, YP Li, ... Military Medical Research 10 (1), 1-29, 2023 | 9 | 2023 |