关注
Sónia S. Leal
Sónia S. Leal
post-doctoral member at FC-UL
在 fc.ul.pt 的电子邮件经过验证
标题
引用次数
引用次数
年份
Metal ions as modulators of protein conformation and misfolding in neurodegeneration
SS Leal, HM Botelho, CM Gomes
Coordination Chemistry Reviews 256 (19-20), 2253-2270, 2012
1772012
Calcium dysregulation links ALS defective proteins and motor neuron selective vulnerability
SS Leal, CM Gomes
Frontiers in cellular neuroscience 9, 225, 2015
912015
Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B (P56S) neurotoxicity
SH Kim, SS Leal, DB Halevy, CM Gomes, S Lev
Journal of Biological Chemistry 285 (18), 13839-13849, 2010
852010
Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: a link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)?
SS Leal, I Cardoso, JS Valentine, CM Gomes
Journal of Biological Chemistry 288 (35), 25219-25228, 2013
712013
The sulphur oxygenase reductase from Acidianus ambivalens is a multimeric protein containing a low-potential mononuclear non-haem iron centre
T Urich, TM Bandeiras, SS Leal, R Rachel, T Albrecht, P Zimmermann, ...
Biochemical Journal 381 (1), 137-146, 2004
712004
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation
JS Cristóvão, VK Morris, I Cardoso, SS Leal, J Martínez, HM Botelho, ...
Science advances 4 (6), eaaq1702, 2018
692018
Characterization of plasma labile heme in hemolytic conditions
Z Gouveia, AR Carlos, X Yuan, F Aires‐da‐Silva, R Stocker, GJ Maghzal, ...
The FEBS journal 284 (19), 3278-3301, 2017
662017
S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation
HM Botelho, SS Leal, I Cardoso, K Yanamandra, LA Morozova-Roche, ...
Journal of Biological Chemistry 287 (50), 42233-42242, 2012
452012
Studies of the molten globule state of ferredoxin: structural characterization and implications on protein folding and iron–sulfur center assembly
SS Leal, CM Gomes
Proteins: Structure, Function, and Bioinformatics 68 (3), 606-616, 2007
432007
Aberrant zinc binding to immature conformers of metal-free copper–zinc superoxide dismutase triggers amorphous aggregation
SS Leal, JS Cristóvão, A Biesemeier, I Cardoso, CM Gomes
Metallomics 7 (2), 333-346, 2015
392015
Lactoperoxidase folding and catalysis relies on the stabilization of the α-helix rich core domain: A thermal unfolding study
B Boscolo, SS Leal, EM Ghibaudi, CM Gomes
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1774 (9), 1164-1172, 2007
392007
Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins
SB Carvalho, HM Botelho, SS Leal, I Cardoso, G Fritz, CM Gomes
PLoS One 8 (10), e76629, 2013
332013
Studies on the degradation pathway of iron-sulfur centers during unfolding of a hyperstable ferredoxin: cluster dissociation, iron release and protein stability
SS Leal, M Teixeira, CM Gomes
JBIC Journal of Biological Inorganic Chemistry 9, 987-996, 2004
302004
The prominent conformational plasticity of lactoperoxidase: a chemical and pH stability analysis
B Boscolo, SS Leal, CA Salgueiro, EM Ghibaudi, CM Gomes
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794 (7), 1041-1048, 2009
242009
A spectroscopic study of the temperature induced modifications on ferredoxin folding and iron− sulfur moieties
S Todorovic, SS Leal, CA Salgueiro, I Zebger, P Hildebrandt, DH Murgida, ...
Biochemistry 46 (37), 10733-10738, 2007
212007
Calcium binding to gatekeeper residues flanking aggregation-prone segments underlies non-fibrillar amyloid traits in superoxide dismutase 1 (SOD1)
SG Estácio, SS Leal, JS Cristóvão, PFN Faísca, CM Gomes
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1854 (2), 118-126, 2015
202015
Natural domain design: enhanced thermal stability of a zinc-lacking ferredoxin isoform shows that a hydrophobic core efficiently replaces the structural metal site
R Rocha, SS Leal, VH Teixeira, M Regalla, H Huber, AM Baptista, ...
Biochemistry 45 (34), 10376-10384, 2006
192006
Crystallographic analysis of the intact metal centres [3Fe–4S] 1+/0 and [4Fe–4S] 2+/1+ in a Zn2+-containing ferredoxin
C Frazão, D Aragão, R Coelho, SS Leal, CM Gomes, M Teixeira, ...
FEBS letters 582 (5), 763-767, 2008
132008
Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins
SS Leal, CM Gomes
Walter de Gruyter 386 (12), 1295-1300, 2005
122005
Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor
M Vieira, SS Leal, CM Gomes, MJ Saraiva
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1862 (4), 797-804, 2016
112016
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