受强制性开放获取政策约束的文章 - Ernesto Freire了解详情
无法在其他位置公开访问的文章：5 篇
Inhibition of HIV‐2 protease by HIV‐1 protease inhibitors in clinical use
ET Brower, UM Bacha, Y Kawasaki, E Freire
Chemical biology & drug design 71 (4), 298-305, 2008
强制性开放获取政策： US National Institutes of Health
Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution
T Miura, K Hidaka, T Uemura, K Kashimoto, Y Hori, Y Kawasaki, ...
Bioorganic & medicinal chemistry letters 20 (16), 4836-4839, 2010
强制性开放获取政策： US National Institutes of Health
The binding thermodynamics of drug candidates
E Freire
Thermodynamics and kinetics of drug binding, 1-13, 2015
强制性开放获取政策： US National Institutes of Health
Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum
T Miura, K Hidaka, Y Azai, K Kashimoto, Y Kawasaki, SE Chen, ...
Bioorganic & Medicinal Chemistry Letters 24 (7), 1698-1701, 2014
强制性开放获取政策： US National Institutes of Health
Some Practical Rules for the Thermodynamic Optimization of Drug Candidates
E Freire
Protein‐Ligand Interactions, 23-31, 2012
强制性开放获取政策： US National Institutes of Health
可在其他位置公开访问的文章：58 篇
Do enthalpy and entropy distinguish first in class from best in class?
E Freire
Drug discovery today 13 (19-20), 869-874, 2008
强制性开放获取政策： US National Institutes of Health
Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo
Q Xu, LM Ensign, NJ Boylan, A Schon, X Gong, JC Yang, NW Lamb, ...
ACS nano 9 (9), 9217-9227, 2015
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Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
Y Do Kwon, M Pancera, P Acharya, IS Georgiev, ET Crooks, J Gorman, ...
Nature structural & molecular biology 22 (7), 522-531, 2015
强制性开放获取政策： US Department of Energy, Bill & Melinda Gates Foundation, US National …
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
NK Kisalu, AH Idris, C Weidle, Y Flores-Garcia, BJ Flynn, BK Sack, ...
Nature medicine 24 (4), 408-416, 2018
强制性开放获取政策： US National Science Foundation, US Department of Energy, US National …
Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120
N Madani, A Schön, AM Princiotto, JM LaLonde, JR Courter, T Soeta, ...
Structure 16 (11), 1689-1701, 2008
强制性开放获取政策： US National Institutes of Health
Isothermal titration calorimetry: general formalism using binding polynomials
E Freire, A Schön, A Velazquez‐Campoy
Methods in enzymology 455, 127-155, 2009
强制性开放获取政策： US National Institutes of Health
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel
C Ma, AL Polishchuk, Y Ohigashi, AL Stouffer, A Schön, E Magavern, ...
Proceedings of the National Academy of Sciences 106 (30), 12283-12288, 2009
强制性开放获取政策： US National Institutes of Health, Howard Hughes Medical Institute
A thermodynamic approach to the affinity optimization of drug candidates
E Freire
Chemical biology & drug design 74 (5), 468-472, 2009
强制性开放获取政策： US National Institutes of Health
Single-chain soluble BG505. SOSIP gp140 trimers as structural and antigenic mimics of mature closed HIV-1 Env
IS Georgiev, MG Joyce, Y Yang, M Sastry, B Zhang, U Baxa, RE Chen, ...
Journal of virology 89 (10), 5318-5329, 2015
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Finding a better path to drug selectivity
Y Kawasaki, E Freire
Drug discovery today 16 (21-22), 985-990, 2011
强制性开放获取政策： US National Institutes of Health
CD4 mimetics sensitize HIV-1-infected cells to ADCC
J Richard, M Veillette, N Brassard, SS Iyer, M Roger, L Martin, M Pazgier, ...
Proceedings of the National Academy of Sciences 112 (20), E2687-E2694, 2015
强制性开放获取政策： Bill & Melinda Gates Foundation, US National Institutes of Health, Canadian …
Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529
M Pancera, YT Lai, T Bylund, A Druz, S Narpala, S O'Dell, A Schön, ...
Nature chemical biology 13 (10), 1115-1122, 2017
强制性开放获取政策： US National Science Foundation, US Department of Energy, US National …
Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist
JR Courter, N Madani, J Sodroski, A Schön, E Freire, PD Kwong, ...
Accounts of chemical research 47 (4), 1228-1237, 2014
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Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies
P Thanigaimalai, S Konno, T Yamamoto, Y Koiwai, A Taguchi, ...
European journal of medicinal chemistry 68, 372-384, 2013
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Small-molecule CD4-mimics: structure-based optimization of HIV-1 entry inhibition
B Melillo, S Liang, J Park, A Schön, JR Courter, JM LaLonde, ...
ACS medicinal chemistry letters 7 (3), 330-334, 2016
强制性开放获取政策： US Department of Energy, US National Institutes of Health
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