| Metabolic gatekeeper function of B-lymphoid transcription factors LN Chan, Z Chen, D Braas, JW Lee, G Xiao, H Geng, KN Cosgun, C Hurtz, ... Nature 542 (7642), 479-483, 2017 | 224 | 2017 |
| Erk negative feedback control enables pre-B cell transformation and represents a therapeutic target in acute lymphoblastic leukemia S Shojaee, R Caeser, M Buchner, E Park, S Swaminathan, C Hurtz, ... Cancer cell 28 (1), 114-128, 2015 | 133 | 2015 |
| Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia H Geng, C Hurtz, KB Lenz, Z Chen, D Baumjohann, S Thompson, ... Cancer cell 27 (3), 409-425, 2015 | 131 | 2015 |
| PTEN opposes negative selection and enables oncogenic transformation of pre-B cells S Shojaee, LN Chan, M Buchner, V Cazzaniga, KN Cosgun, H Geng, ... Nature medicine 22 (4), 379-387, 2016 | 128 | 2016 |
| B-cell-specific diversion of glucose carbon utilization reveals a unique vulnerability in B cell malignancies G Xiao, LN Chan, L Klemm, D Braas, Z Chen, H Geng, QC Zhang, ... Cell 173 (2), 470-484. e18, 2018 | 113 | 2018 |
| Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia BK Masouleh, H Geng, C Hurtz, LN Chan, AC Logan, MS Chang, ... Proceedings of the National Academy of Sciences 111 (21), E2219-E2228, 2014 | 104 | 2014 |
| SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia P Ramezani-Rad, H Geng, C Hurtz, LN Chan, Z Chen, H Jumaa, ... Blood, The Journal of the American Society of Hematology 121 (1), 148-155, 2013 | 83 | 2013 |
| A novel approach to tag and identify geranylgeranylated proteins LN Chan, C Hart, L Guo, T Nyberg, BSJ Davies, LG Fong, SG Young, ... Electrophoresis 30 (20), 3598-3606, 2009 | 82 | 2009 |
| IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells J Lee, ME Robinson, N Ma, D Artadji, MA Ahmed, G Xiao, T Sadras, ... Nature 588 (7838), 491-497, 2020 | 76 | 2020 |
| Signalling input from divergent pathways subverts B cell transformation LN Chan, MA Murakami, ME Robinson, R Caeser, T Sadras, J Lee, ... Nature 583 (7818), 845-851, 2020 | 52 | 2020 |
| Loss of Pax5 exploits Sca1-BCR-ABLp190 susceptibility to confer the metabolic shift essential for pB-ALL A Martín-Lorenzo, F Auer, LN Chan, I García-Ramírez, I Gonzalez-Herrero, ... Cancer research 78 (10), 2669-2679, 2018 | 49 | 2018 |
| In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells DB Zimonjic, LN Chan, V Tripathi, J Lu, O Kwon, NC Popescu, DR Lowy, ... BMC cancer 13 (1), 1-10, 2013 | 35 | 2013 |
| Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I LN Chan, HDG Fiji, M Watanabe, O Kwon, F Tamanoi PLoS One 6 (10), e26135, 2011 | 24 | 2011 |
| Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia C Hurtz, LN Chan, H Geng, E Ballabio, G Xiao, G Deb, H Khoury, ... Genes & Development 33 (17-18), 1265-1279, 2019 | 23 | 2019 |
| SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies E Leveille, LN Chan, AS Mirza, K Kume, M Müschen Cellular Signalling, 110331, 2022 | 19 | 2022 |
| B-cell identity as a metabolic barrier against malignant transformation LN Chan, M Müschen Experimental hematology 53, 1-6, 2017 | 18 | 2017 |
| Metabolic Gatekeepers of Pathological B Cell Activation T Sadras, LN Chan, G Xiao, M Müschen Annual Review of Pathology: Mechanisms of Disease 16, 323-349, 2021 | 16 | 2021 |
| PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis L Pan, C Hong, LN Chan, G Xiao, P Malvi, ME Robinson, H Geng, ... Proceedings of the National Academy of Sciences 118 (7), 2021 | 13 | 2021 |
| Small-molecule inhibitors of GGTase-I from the heterocycle library derived from phosphine catalysis LN Chan, M Watanabe, O Kwon, F Tamanoi The Enzymes 30, 165-177, 2011 | 3 | 2011 |
| Metabolic determinants of B-cell selection LN Chan, E Aghania, E Leveille, M Müschen Biochemical Society Transactions 49 (3), 1467-1478, 2021 | 2 | 2021 |
