| Agouti-related peptide–expressing neurons are mandatory for feeding E Gropp, M Shanabrough, E Borok, AW Xu, R Janoschek, T Buch, L Plum, ... Nature neuroscience 8 (10), 1289-1291, 2005 | 883 | 2005 |
| A guide to analysis of mouse energy metabolism MH Tschöp, JR Speakman, JRS Arch, J Auwerx, JC Brüning, L Chan, ... Nature methods 9 (1), 57-63, 2012 | 800 | 2012 |
| Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production AC Könner, R Janoschek, L Plum, SD Jordan, E Rother, X Ma, C Xu, ... Cell metabolism 5 (6), 438-449, 2007 | 774 | 2007 |
| The role of insulin receptor signaling in the brain L Plum, M Schubert, JC Brüning Trends in Endocrinology & Metabolism 16 (2), 59-65, 2005 | 758 | 2005 |
| Central insulin action in energy and glucose homeostasis L Plum, BF Belgardt, JC Brüning The Journal of clinical investigation 116 (7), 1761-1766, 2006 | 562 | 2006 |
| Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity L Plum, X Ma, B Hampel, N Balthasar, R Coppari, H Münzberg, ... The Journal of clinical investigation 116 (7), 1886-1901, 2006 | 358 | 2006 |
| MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a … P Ambery, VE Parker, M Stumvoll, MG Posch, T Heise, L Plum-Moerschel, ... The Lancet 391 (10140), 2607-2618, 2018 | 295 | 2018 |
| Effect of the sodium glucose co‐transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus S Sha, D Polidori, T Heise, J Natarajan, K Farrell, SS Wang, D Sica, ... Diabetes, Obesity and Metabolism 16 (11), 1087-1095, 2014 | 267 | 2014 |
| The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake L Plum, HV Lin, R Dutia, J Tanaka, KS Aizawa, M Matsumoto, AJ Kim, ... Nature medicine 15 (10), 1195-1201, 2009 | 195 | 2009 |
| Peripheral hyperinsulinemia promotes tau phosphorylation in vivo S Freude, L Plum, J Schnitker, U Leeser, M Udelhoven, W Krone, ... Diabetes 54 (12), 3343-3348, 2005 | 190 | 2005 |
| FoxO1 target Gpr17 activates AgRP neurons to regulate food intake H Ren, IJ Orozco, Y Su, S Suyama, R Gutiérrez-Juárez, TL Horvath, ... Cell 149 (6), 1314-1326, 2012 | 188 | 2012 |
| Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons HV Lin, L Plum, H Ono, R Gutiérrez-Juárez, M Shanabrough, E Borok, ... Diabetes 59 (2), 337-346, 2010 | 186 | 2010 |
| Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation L Plum, E Rother, H Münzberg, FT Wunderlich, DA Morgan, B Hampel, ... Cell metabolism 6 (6), 431-445, 2007 | 148 | 2007 |
| Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial IB Halberg, K Lyby, K Wassermann, T Heise, E Zijlstra, L Plum-Mörschel The Lancet Diabetes & Endocrinology 7 (3), 179-188, 2019 | 143 | 2019 |
| Single copy shRNA configuration for ubiquitous gene knockdown in mice J Seibler, B Küter-Luks, H Kern, S Streu, L Plum, J Mauer, R Kühn, ... Nucleic acids research 33 (7), e67-e67, 2005 | 138 | 2005 |
| Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance J Mauer, B Chaurasia, L Plum, T Quast, B Hampel, M Blüher, W Kolanus, ... PLoS genetics 6 (5), e1000938, 2010 | 116 | 2010 |
| A metabolic syndrome of hypertension, hyperinsulinaemia and hypercholesterolaemia in the New Zealand obese mouse Ortlepp, Kluge, Giesen, Plum, Radke, Hanrath, Joost European journal of clinical investigation 30 (3), 195-202, 2000 | 112 | 2000 |
| Pharmacodynamic differences between canagliflozin and dapagliflozin: results of a randomized, double‐blind, crossover study S Sha, D Polidori, K Farrell, A Ghosh, J Natarajan, N Vaccaro, J Pinheiro, ... Diabetes, Obesity and Metabolism 17 (2), 188-197, 2015 | 111 | 2015 |
| Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non‐alcoholic fatty liver disease assessed by magnetic … A Flint, G Andersen, P Hockings, L Johansson, A Morsing, ... Alimentary pharmacology & therapeutics 54 (9), 1150-1161, 2021 | 103 | 2021 |
| Efficacy, safety, and mechanistic insights of cotadutide, a dual receptor glucagon-like peptide-1 and glucagon agonist VER Parker, D Robertson, T Wang, DC Hornigold, M Petrone, AT Cooper, ... The Journal of Clinical Endocrinology & Metabolism 105 (3), 803-820, 2020 | 97 | 2020 |
