A transcriptomic atlas of aged human microglia M Olah, E Patrick, AC Villani, J Xu, CC White, KJ Ryan, P Piehowski, ... Nature communications 9 (1), 539, 2018 | 406 | 2018 |
CD33 modulates TREM2: convergence of Alzheimer loci G Chan, CC White, PA Winn, M Cimpean, JM Replogle, LR Glick, ... Nature neuroscience 18 (11), 1556-1558, 2015 | 159 | 2015 |
CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility T Raj, KJ Ryan, JM Replogle, LB Chibnik, L Rosenkrantz, A Tang, ... Human molecular genetics 23 (10), 2729-2736, 2014 | 158 | 2014 |
A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants KJ Ryan, CC White, K Patel, J Xu, M Olah, JM Replogle, M Frangieh, ... Science translational medicine 9 (421), eaai7635, 2017 | 124 | 2017 |
Noradrenaline acting at β-adrenoceptors induces expression of IL-1β and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex EN McNamee, ÉW Griffin, KM Ryan, KJ Ryan, S Heffernan, A Harkin, ... Neuropharmacology 59 (1-2), 37-48, 2010 | 81 | 2010 |
The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity LC Gleeson, KJ Ryan, ÉW Griffin, TJ Connor, A Harkin Brain, behavior, and immunity 24 (8), 1354-1361, 2010 | 72 | 2010 |
Noradrenaline acting at central β-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: Implications for neurodegeneration EN McNamee, KM Ryan, ÉW Griffin, RE González-Reyes, KJ Ryan, ... Brain, Behavior, and Immunity 24 (4), 660-671, 2010 | 70 | 2010 |
Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci G Chan, CC White, PA Winn, M Cimpean, JM Replogle, LR Glick, ... Neurology: Genetics 2 (4), e90, 2016 | 35 | 2016 |
Effect of body tilt angle on fatigue and EMG activities in lower limbs during cycling M Egaña, K Ryan, SA Warmington, S Green European journal of applied physiology 108, 649-656, 2010 | 32 | 2010 |
Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB KJ Ryan, É Griffin, JD Yssel, KM Ryan, EN McNamee, A Harkin, ... Neurochemistry international 63 (5), 368-378, 2013 | 27 | 2013 |
Spatial orienting of attention to social cues is modulated by cue type and gender of viewer SM Cooney, N Brady, K Ryan Experimental brain research 235 (5), 1481-1490, 2017 | 25 | 2017 |
A transcriptomic atlas of aged human microglia. Nat Commun 9: 539 M Olah, E Patrick, AC Villani, J Xu, CC White, KJ Ryan, P Piehowski, ... | 18 | 2018 |
The β2-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1β administration … ÉW Griffin, JD Yssel, E O’Neill, KJ Ryan, N Boyle, P Harper, A Harkin, ... Immunopharmacology and immunotoxicology 40 (2), 99-106, 2018 | 15 | 2018 |
Complementary anti-inflammatory actions of the β2-adrenoceptor agonist clenbuterol and the glucocorticoid dexamethasone in rat brain KJ Ryan, ÉW Griffin, TJ Connor Journal of neuroimmunology 232 (1-2), 209-216, 2011 | 15 | 2011 |
A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants. Sci Transl Med 9: eaai7635 KJ Ryan, CC White, K Patel, J Xu, M Olah, JM Replogle, M Frangieh, ... | 10 | 2017 |
Clenbuterol activates the central IL-1 system via the β2-adrenoceptor without provoking inflammatory response related behaviours in rats KM Ryan, ÉW Griffin, KJ Ryan, R Tanveer, N Vanattou-Saifoudine, ... Brain, behavior, and immunity 56, 114-129, 2016 | 9 | 2016 |
Context-specific effects of neurodegenerative disease variants in a model of human microglia KJ Ryan, CC White, K Patel, J Xu, M Olah, JM Replogle, M Frangieh, ... Science translational medicine 9 (421), 2017 | 4 | 2017 |
Predictors of slowed non-culprit blood flow post thrombolysis C McLean, M Rizzo, K Ryan, C McCabe, C Cannon, M Gibson JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 29 (2), 9463-9463, 1997 | 4 | 1997 |
GW5074 increases microglial phagocytic activities: potential therapeutic direction for Alzheimer’s disease SM Connor, M Rashid, KJ Ryan, K Patel, JD Boyd, J Smith, W Elyaman, ... Frontiers in Cellular Neuroscience 16, 894601, 2022 | 3 | 2022 |
Correcting the functional consequences of the CD33 Alzheimer's disease risk allele using small molecules JD Boyd | 3 | 2014 |