| Cytoplasmic TDP-43 de-mixing independent of stress granules drives inhibition of nuclear import, loss of nuclear TDP-43, and cell death F Gasset-Rosa, S Lu, H Yu, C Chen, Z Melamed, L Guo, J Shorter, ... Neuron 102 (2), 339-357. e7, 2019 | 374 | 2019 |
| Allosteric activation of functionally asymmetric RAF kinase dimers J Hu, EC Stites, H Yu, EA Germino, HS Meharena, PJS Stork, AP Kornev, ... Cell 154 (5), 1036-1046, 2013 | 312 | 2013 |
| Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis S Akilesh, H Suleiman, H Yu, MC Stander, P Lavin, R Gbadegesin, ... The Journal of clinical investigation 121 (10), 4127-4137, 2011 | 295 | 2011 |
| HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells H Yu, S Lu, K Gasior, D Singh, S Vazquez-Sanchez, O Tapia, D Toprani, ... Science 371 (6529), 2021 | 216 | 2021 |
| Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF J Hu, H Yu, AP Kornev, J Zhao, EL Filbert, SS Taylor, AS Shaw Proceedings of the National Academy of Sciences 108 (15), 6067-6072, 2011 | 148 | 2011 |
| Rac1 activation in podocytes induces rapid foot process effacement and proteinuria H Yu, H Suleiman, AHJ Kim, JH Miner, A Dani, AS Shaw, S Akilesh Molecular and cellular biology 33 (23), 4755-4764, 2013 | 145 | 2013 |
| PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel J Yang, J Chen, M del Carmen Vitery, J Osei-Owusu, J Chu, H Yu, S Sun, ... Science 364 (6438), 395-399, 2019 | 104 | 2019 |
| A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis H Yu, M Artomov, S Brähler, MC Stander, G Shamsan, MG Sampson, ... The Journal of clinical investigation 126 (3), 1067-1078, 2016 | 69 | 2016 |
| Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition S Lu, J Hu, OA Arogundade, A Goginashvili, S Vazquez-Sanchez, ... Nature cell biology 24 (9), 1378-1393, 2022 | 60 | 2022 |
| Intravital and kidney slice imaging of podocyte membrane dynamics S Brähler, H Yu, H Suleiman, GM Krishnan, BT Saunders, JB Kopp, ... Journal of the American Society of Nephrology 27 (11), 3285-3290, 2016 | 56 | 2016 |
| Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5 X Sun, X Shi, X Sun, Y Luo, X Wu, C Yao, H Yu, D Li, M Liu, J Zhou Acta pharmacologica Sinica 32 (12), 1543-1548, 2011 | 51 | 2011 |
| Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment LL Jiang, B Zhu, Y Zhao, X Li, T Liu, J Pina-Crespo, L Zhou, W Xu, ... The Journal of Clinical Investigation 129 (8), 3103-3120, 2019 | 41 | 2019 |
| Validating the mitotic kinesin Eg5 as a therapeutic target in pancreatic cancer cells and tumor xenografts using a specific inhibitor M Liu, H Yu, L Huo, J Liu, M Li, J Zhou Biochemical pharmacology 76 (2), 169-178, 2008 | 40 | 2008 |
| Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells L Sun, D Li, X Dong, H Yu, JT Dong, C Zhang, X Lu, J Zhou Biochemical pharmacology 75 (5), 1027-1034, 2008 | 22 | 2008 |
| HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science 371, eabb4309 H Yu, S Lu, K Gasior, D Singh, S Vazquez-Sanchez, O Tapia, D Toprani, ... | 15 | 2021 |
| Tuning apoptosis and neuroinflammation: TBK1 restrains RIPK1 H Yu, DW Cleveland Cell 174 (6), 1339-1341, 2018 | 15 | 2018 |
| Tuning T cell signaling sensitivity alters the behavior of CD4+ T cells during an immune response AAV Milam, JM Bartleson, DL Donermeyer, S Horvath, V Durai, S Raju, ... The Journal of Immunology 200 (10), 3429-3437, 2018 | 13 | 2018 |
| Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation L Sun, X Sun, S Xie, H Yu, D Zhong Biochemical and biophysical research communications 447 (3), 465-470, 2014 | 7 | 2014 |
| Genetic and cellular studies of the Podocyte in focal segmental Glomerulosclerosis H Yu Washington University in St. Louis, 2015 | 1 | 2015 |
| CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation VI Ko, K Ong, DW Cleveland, H Yu, JM Ravits Neurobiology of Disease 196, 106516, 2024 | | 2024 |
Don W ClevelandUniversity of California at San Diego在 UCSD.EDU 的电子邮件经过验证
