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Dennis Buckley
Dennis Buckley
NIBR
在 novartis.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Phthalimide conjugation as a strategy for in vivo target protein degradation
GE Winter, DL Buckley, J Paulk, JM Roberts, A Souza, S Dhe-Paganon, ...
Science 348 (6241), 1376-1381, 2015
15252015
Catalytic in vivo protein knockdown by small-molecule PROTACs
DP Bondeson, A Mares, IED Smith, E Ko, S Campos, AH Miah, ...
Nature chemical biology 11 (8), 611-617, 2015
11172015
YY1 is a structural regulator of enhancer-promoter loops
AS Weintraub, CH Li, AV Zamudio, AA Sigova, NM Hannett, DS Day, ...
Cell 171 (7), 1573-1588. e28, 2017
8852017
The dTAG system for immediate and target-specific protein degradation
B Nabet, JM Roberts, DL Buckley, J Paulk, S Dastjerdi, A Yang, ...
Nature chemical biology 14 (5), 431-441, 2018
7692018
Targeting the von Hippel–Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction
DL Buckley, I Van Molle, PC Gareiss, HS Tae, J Michel, DJ Noblin, ...
Journal of the American Chemical Society 134 (10), 4465-4468, 2012
5222012
Plasticity in binding confers selectivity in ligand-induced protein degradation
RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ...
Nature chemical biology 14 (7), 706-714, 2018
4632018
HaloPROTACS: use of small molecule PROTACs to induce degradation of HaloTag fusion proteins
DL Buckley, K Raina, N Darricarrere, J Hines, JL Gustafson, IE Smith, ...
ACS chemical biology 10 (8), 1831-1837, 2015
4122015
BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment
GE Winter, A Mayer, DL Buckley, MA Erb, JE Roderick, S Vittori, JM Reyes, ...
Molecular cell 67 (1), 5-18. e19, 2017
4062017
A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader
HT Huang, D Dobrovolsky, J Paulk, G Yang, EL Weisberg, ZM Doctor, ...
Cell chemical biology 25 (1), 88-99. e6, 2018
3822018
Small Molecule Inhibitors of the Interaction Between the E3 Ligase VHL and HIF1α
DL Buckley, JL Gustafson, I Van Molle, AG Roth, HS Tae, PC Gareiss, ...
Angewandte Chemie (International Ed. in English) 51 (46), 11463, 2012
3182012
Transcription control by the ENL YEATS domain in acute leukaemia
MA Erb, TG Scott, BE Li, H Xie, J Paulk, HS Seo, A Souza, JM Roberts, ...
Nature 543 (7644), 270-274, 2017
3072017
Degradation of the BAF complex factor BRD9 by heterobifunctional ligands
D Remillard, DL Buckley, J Paulk, GL Brien, M Sonnett, HS Seo, ...
Angewandte Chemie International Edition 56 (21), 5738-5743, 2017
3002017
Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
X Dai, W Gan, X Li, S Wang, W Zhang, L Huang, S Liu, Q Zhong, J Guo, ...
Nature medicine 23 (9), 1063-1071, 2017
2912017
Mutant NPM1 maintains the leukemic state through HOX expression
L Brunetti, MC Gundry, D Sorcini, AG Guzman, YH Huang, ...
Cancer cell 34 (3), 499-512. e9, 2018
2492018
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands
LN Gechijian, DL Buckley, MA Lawlor, JM Reyes, J Paulk, CJ Ott, ...
Nature chemical biology 14 (4), 405-412, 2018
2202018
Dissecting fragment-based lead discovery at the von Hippel-Lindau protein: hypoxia inducible factor 1α protein-protein interface
I Van Molle, A Thomann, DL Buckley, EC So, S Lang, CM Crews, A Ciulli
Chemistry & biology 19 (10), 1300-1312, 2012
2102012
Small‐molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system
DL Buckley, CM Crews
Angewandte Chemie International Edition 53 (9), 2312-2330, 2014
1952014
Small‐molecule‐mediated degradation of the androgen receptor through hydrophobic tagging
JL Gustafson, TK Neklesa, CS Cox, AG Roth, DL Buckley, HS Tae, ...
Angewandte Chemie 127 (33), 9795-9798, 2015
1862015
Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an E3 ubiquitin ligase
CM Crews, D Buckley, A Ciulli, W Jorgensen, PC Gareiss, I Van Molle, ...
US Patent 10,730,862, 2020
1592020
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
B Nabet, FM Ferguson, BKA Seong, M Kuljanin, AL Leggett, ML Mohardt, ...
Nature communications 11 (1), 4687, 2020
1582020
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