| BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II–DNA complexes H Sasanuma, M Tsuda, S Morimoto, LK Saha, MM Rahman, Y Kiyooka, ... Proceedings of the National Academy of Sciences 115 (45), E10642-E10651, 2018 | 86 | 2018 |
| Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress, and enhances the chemotherapeutic activity of widely used DNA damaging agents U Jo, IS Senatorov, A Zimmermann, LK Saha, Y Murai, SH Kim, ... Molecular cancer therapeutics 20 (8), 1431-1441, 2021 | 75 | 2021 |
| Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC) Y Sun, S Saha, W Wang, LK Saha, SYN Huang, Y Pommier DNA repair 89, 102837, 2020 | 74 | 2020 |
| Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways Y Sun, LK Saha, S Saha, U Jo, Y Pommier DNA repair 94, 102926, 2020 | 63 | 2020 |
| SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors U Jo, Y Murai, S Chakka, L Chen, K Cheng, J Murai, LK Saha, ... Proceedings of the National Academy of Sciences 118 (6), e2015654118, 2021 | 45 | 2021 |
| Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes LK Saha, Y Murai, S Saha, U Jo, M Tsuda, S Takeda, Y Pommier Nucleic acids research 49 (18), 10493-10506, 2021 | 26 | 2021 |
| The ARK assay is a sensitive and versatile method for the global detection of DNA-protein crosslinks Q Hu, N Klages-Mundt, R Wang, E Lynn, LK Saha, H Zhang, M Srivastava, ... Cell reports 30 (4), 1235-1245. e4, 2020 | 25 | 2020 |
| TOP1-DNA trapping by exatecan and combination therapy with ATR inhibitor U Jo, Y Murai, KK Agama, Y Sun, LK Saha, X Yang, Y Arakawa, S Gayle, ... Molecular cancer therapeutics 21 (7), 1090-1102, 2022 | 22 | 2022 |
| Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells LK Saha, M Wakasugi, S Akter, R Prasad, SH Wilson, N Shimizu, ... Proceedings of the National Academy of Sciences 117 (25), 14412-14420, 2020 | 22 | 2020 |
| Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5 S Saha, X Yang, SN Huang, K Agama, SA Baechler, Y Sun, H Zhang, ... Cell reports 40 (2), 2022 | 21 | 2022 |
| UBC13-mediated ubiquitin signaling promotes removal of blocking adducts from DNA double-strand breaks R Akagawa, HT Trinh, LK Saha, M Tsuda, K Hirota, S Yamada, A Shibata, ... Iscience 23 (4), 2020 | 18 | 2020 |
| ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer CW Schultz, Y Zhang, R Elmeskini, A Zimmermann, H Fu, Y Murai, ... EMBO Molecular Medicine 15 (8), e17313, 2023 | 12 | 2023 |
| Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms LK Saha, S Kim, H Kang, S Akter, K Choi, T Sakuma, T Yamamoto, ... Environmental and Molecular Mutagenesis 59 (6), 529-538, 2018 | 12 | 2018 |
| Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes LK Saha, S Saha, X Yang, SN Huang, Y Sun, U Jo, Y Pommier Nature Communications 14 (1), 1925, 2023 | 8 | 2023 |
| Enhancing the sensitivity of the thymidine kinase assay by using DNA repair‐deficient human TK6 cells MA Ibrahim, M Yasui, LK Saha, H Sasanuma, M Honma, S Takeda Environmental and Molecular Mutagenesis 61 (6), 602-610, 2020 | 7 | 2020 |
| A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage RWS Jianfeng Li, Alison Beiser, Nupur B Dey, Shunichi Takeda, Liton Kumar ... NAR Genomics and Bioinformatics 4 (3), lqac065, 2022 | 3 | 2022 |
| TOP3A coupling with replication forks and repair of TOP3A cleavage complexes LK Saha, Y Pommier Cell Cycle, 1-16, 2024 | 1 | 2024 |
| The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes S Saha, SN Huang, X Yang, LK Saha, Y Sun, P Khandagale, LM Jenkins, ... Nature Communications 14 (1), 7524, 2023 | 1 | 2023 |
| ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer CW Schultz, Y Zhang, R Elmeskini, A Zimmermann, H Fu, Y Murai, ... bioRxiv, 2022.12. 16.520783, 2022 | 1 | 2022 |
| Abstract LB167: Acetalax (Oxyphenisatin acetate, NSC 59687) and bisacodyl (dulcolax) cause oncosis in triple negative breast cancer by poisoning the ion exchange membrane … M Mizunuma, C Redon, L Saha, N Takebe, YG Pommier Cancer Research 84 (7_Supplement), LB167-LB167, 2024 | | 2024 |
