I-motif DNA structures are formed in the nuclei of human cells M Zeraati, DB Langley, P Schofield, AL Moye, R Rouet, WE Hughes, ... Nature chemistry 10 (6), 631-637, 2018 | 520 | 2018 |
Selection of human antibody fragments by phage display CMY Lee, N Iorno, F Sierro, D Christ Nature protocols 2 (11), 3001-3008, 2007 | 326 | 2007 |
Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells NJ Kräutler, D Suan, D Butt, K Bourne, JR Hermes, TD Chan, C Sundling, ... The Journal of experimental medicine 214 (5), 1259, 2017 | 295 | 2017 |
Challenges and opportunities for non-antibody scaffold drugs R Vazquez-Lombardi, TG Phan, C Zimmermann, D Lowe, L Jermutus, ... Drug discovery today 20 (10), 1271-1283, 2015 | 291 | 2015 |
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity Z Sabouri, P Schofield, K Horikawa, E Spierings, D Kipling, KL Randall, ... Proceedings of the National Academy of Sciences 111 (25), E2567-E2575, 2014 | 277 | 2014 |
General strategy for the generation of human antibody variable domains with increased aggregation resistance K Dudgeon, R Rouet, I Kokmeijer, P Schofield, J Stolp, D Langley, ... Proceedings of the National Academy of Sciences 109 (27), 10879-10884, 2012 | 221 | 2012 |
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan C Vennin, P Mélénec, R Rouet, M Nobis, AS Cazet, KJ Murphy, ... Nature communications 10 (1), 3637, 2019 | 219 | 2019 |
The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells D Gatto, K Wood, I Caminschi, D Murphy-Durland, P Schofield, D Christ, ... Nature immunology 14 (5), 446-453, 2013 | 211 | 2013 |
Aggregation, stability, and formulation of human antibody therapeutics D Lowe, K Dudgeon, R Rouet, P Schofield, L Jermutus, D Christ Advances in protein chemistry and structural biology 84, 41-61, 2011 | 206 | 2011 |
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer SA O'Toole, DA Machalek, RF Shearer, EKA Millar, R Nair, P Schofield, ... Cancer research 71 (11), 4002-4014, 2011 | 188 | 2011 |
Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization JH Reed, J Jackson, D Christ, CC Goodnow The Journal of experimental medicine 213 (7), 1255, 2016 | 164 | 2016 |
Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination DL Burnett, DB Langley, P Schofield, JR Hermes, TD Chan, J Jackson, ... Science 360 (6385), 223-226, 2018 | 142 | 2018 |
A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity HM McGuire, A Vogelzang, CS Ma, WE Hughes, PA Silveira, SG Tangye, ... Immunity 34 (4), 602-615, 2011 | 128 | 2011 |
SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants F Tea, A Ospina Stella, A Aggarwal, D Ross Darley, D Pilli, D Vitale, ... PLoS medicine 18 (7), e1003656, 2021 | 127 | 2021 |
Thermodynamically stable aggregation-resistant antibody domains through directed evolution K Famm, L Hansen, D Christ, G Winter Journal of molecular biology 376 (4), 926-931, 2008 | 127 | 2008 |
Stability engineering of the human antibody repertoire R Rouet, D Lowe, D Christ FEBS letters 588 (2), 269-277, 2014 | 117 | 2014 |
Lymphoma driver mutations in the pathogenic evolution of an iconic human autoantibody M Singh, KJL Jackson, JJ Wang, P Schofield, MA Field, D Koppstein, ... Cell 180 (5), 878-894. e19, 2020 | 108 | 2020 |
Transient expression of human antibodies in mammalian cells R Vazquez-Lombardi, D Nevoltris, A Luthra, P Schofield, C Zimmermann, ... Nature Protocols 13 (1), 99-117, 2018 | 101 | 2018 |
FAS inactivation releases unconventional germinal center B cells that escape antigen control and drive IgE and autoantibody production D Butt, TD Chan, K Bourne, JR Hermes, A Nguyen, A Statham, ... Immunity 42 (5), 890-902, 2015 | 100 | 2015 |
Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models HM McGuire, S Walters, A Vogelzang, CMY Lee, KE Webster, J Sprent, ... Diabetes 60 (3), 867-875, 2011 | 94 | 2011 |