Lipidomic analysis of α-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for Parkinson treatment S Fanning, A Haque, T Imberdis, V Baru, MI Barrasa, S Nuber, D Termine, ... Molecular cell 73 (5), 1001-1014. e8, 2019 | 242 | 2019 |
Tat protein of human immunodeficiency virus type 1 subtype C strains is a defective chemokine U Ranga, R Shankarappa, NB Siddappa, L Ramakrishna, R Nagendran, ... Journal of virology 78 (5), 2586-2590, 2004 | 213 | 2004 |
Phospholipids regulate localization and activity of mDia1 formin N Ramalingam, H Zhao, D Breitsprecher, P Lappalainen, J Faix, ... European journal of cell biology 89 (10), 723-732, 2010 | 86 | 2010 |
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells U Dettmer, N Ramalingam, VE von Saucken, TE Kim, AJ Newman, ... Human molecular genetics 26 (18), 3466-3481, 2017 | 85 | 2017 |
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase T Imberdis, J Negri, N Ramalingam, E Terry-Kantor, GPH Ho, S Fanning, ... Proceedings of the National Academy of Sciences 116 (41), 20760-20769, 2019 | 81 | 2019 |
Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1 F Bartolini, N Ramalingam, GG Gundersen Molecular biology of the cell 23 (20), 4032-4040, 2012 | 79 | 2012 |
An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells F Bartolini, L Andres-Delgado, X Qu, S Nik, N Ramalingam, L Kremer, ... Molecular biology of the cell 27 (11), 1797-1808, 2016 | 63 | 2016 |
The actinome of Dictyostelium discoideum in comparison to actins and actin-related proteins from other organisms JM Joseph, P Fey, N Ramalingam, XI Liu, M Rohlfs, AA Noegel, ... PloS one 3 (7), e2654, 2008 | 58 | 2008 |
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity N Ramalingam, SX Jin, TE Moors, L Fonseca-Ornelas, K Shimanaka, ... npj Parkinson's Disease 9 (1), 4, 2023 | 46 | 2023 |
A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement N Ramalingam, C Franke, E Jaschinski, M Winterhoff, Y Lu, S Brühmann, ... Nature communications 6 (1), 8496, 2015 | 43 | 2015 |
Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts EJ Morris, GPF Nader, N Ramalingam, F Bartolini, GG Gundersen PloS one 9 (3), e91568, 2014 | 43 | 2014 |
Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins C Litschko, S Brühmann, A Csiszár, T Stephan, V Dimchev, ... Proceedings of the National Academy of Sciences 116 (9), 3594-3603, 2019 | 41 | 2019 |
Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease X Sun, P Aimé, D Dai, N Ramalingam, JF Crary, RE Burke, LA Greene, ... Experimental neurology 303, 95-107, 2018 | 39 | 2018 |
Upregulation of Cellular Palmitoylation Mitigates α‐Synuclein Accumulation and Neurotoxicity GPH Ho, N Ramalingam, T Imberdis, EC Wilkie, U Dettmer, DJ Selkoe Movement Disorders 36 (2), 348-359, 2021 | 26 | 2021 |
Rapid alpha-synuclein toxicity in a neural cell model and its rescue by a stearoyl-CoA desaturase inhibitor E Terry-Kantor, A Tripathi, T Imberdis, ZM LaVoie, GPH Ho, D Selkoe, ... International journal of molecular sciences 21 (15), 5193, 2020 | 22 | 2020 |
Pathogenic mechanisms of cytosolic and membrane-enriched α-synuclein converge on fatty acid homeostasis A Tripathi, H Alnakhala, E Terry-Kantor, A Newman, L Liu, T Imberdis, ... Journal of Neuroscience 42 (10), 2116-2130, 2022 | 17 | 2022 |
Temperature is a key determinant of alpha-and beta-synuclein membrane interactions in neurons N Ramalingam, U Dettmer Journal of Biological Chemistry 296, 2021 | 16 | 2021 |
Characterization of the Ste20-like kinase Krs1 of Dictyostelium discoideum R Arasada, H Son, N Ramalingam, L Eichinger, M Schleicher, M Rohlfs European journal of cell biology 85 (9-10), 1059-1068, 2006 | 13 | 2006 |
Studying α-synuclein conformation by intact-cell cross-linking T Imberdis, S Fanning, A Newman, N Ramalingam, U Dettmer Alpha-Synuclein: Methods and Protocols, 77-91, 2019 | 12 | 2019 |
Excess membrane binding of monomeric alpha-, beta-and gamma-synuclein is invariably associated with inclusion formation and toxicity TE Kim, AJ Newman, T Imberdis, L Brontesi, A Tripathi, N Ramalingam, ... Human Molecular Genetics 30 (23), 2332-2346, 2021 | 11 | 2021 |