| Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation N Arpaia, C Campbell, X Fan, S Dikiy, J Van Der Veeken, P Deroos, H Liu, ... Nature 504 (7480), 451-455, 2013 | 4214 | 2013 |
| The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate PS Ward, J Patel, DR Wise, O Abdel-Wahab, BD Bennett, HA Coller, ... Cancer cell 17 (3), 225-234, 2010 | 2300 | 2010 |
| ATP-citrate lyase links cellular metabolism to histone acetylation KE Wellen, G Hatzivassiliou, UM Sachdeva, TV Bui, JR Cross, ... Science 324 (5930), 1076-1080, 2009 | 2202 | 2009 |
| Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile CG Buffie, V Bucci, RR Stein, PT McKenney, L Ling, A Gobourne, D No, ... Nature 517 (7533), 205-208, 2015 | 1865 | 2015 |
| Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation CM Krawczyk, T Holowka, J Sun, J Blagih, E Amiel, RJ DeBerardinis, ... Blood, The Journal of the American Society of Hematology 115 (23), 4742-4749, 2010 | 1251 | 2010 |
| Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability DR Wise, PS Ward, JES Shay, JR Cross, JJ Gruber, UM Sachdeva, ... Proceedings of the National Academy of Sciences 108 (49), 19611-19616, 2011 | 1093 | 2011 |
| Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells BW Carey, LWS Finley, JR Cross, CD Allis, CB Thompson Nature 518 (7539), 413-416, 2015 | 922 | 2015 |
| Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer Q Chen, A Boire, X Jin, M Valiente, EE Er, A Lopez-Soto, L S. Jacob, ... Nature 533 (7604), 493-498, 2016 | 832 | 2016 |
| Intestinal Blautia is associated with reduced death from graft-versus-host disease RR Jenq, Y Taur, SM Devlin, DM Ponce, JD Goldberg, KF Ahr, ... Biology of Blood and Marrow Transplantation 21 (8), 1373-1383, 2015 | 742 | 2015 |
| Clinical and biological correlates of neurotoxicity associated with CAR T-cell therapy in patients with B-cell acute lymphoblastic leukemia BD Santomasso, JH Park, D Salloum, I Riviere, J Flynn, E Mead, E Halton, ... Cancer discovery 8 (8), 958-971, 2018 | 732 | 2018 |
| Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids JJ Kamphorst, JR Cross, J Fan, E De Stanchina, R Mathew, EP White, ... Proceedings of the National Academy of Sciences 110 (22), 8882-8887, 2013 | 691 | 2013 |
| Connecting copper and cancer: from transition metal signalling to metalloplasia EJ Ge, AI Bush, A Casini, PA Cobine, JR Cross, GM DeNicola, QP Dou, ... Nature Reviews Cancer 22 (2), 102-113, 2022 | 672 | 2022 |
| Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells C Campbell, PT McKenney, D Konstantinovsky, OI Isaeva, M Schizas, ... Nature 581 (7809), 475-479, 2020 | 521 | 2020 |
| Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation BR Sabari, Z Tang, H Huang, V Yong-Gonzalez, H Molina, HE Kong, ... Molecular cell 58 (2), 203-215, 2015 | 516 | 2015 |
| Hypoxia induces production of L-2-hydroxyglutarate AM Intlekofer, RG Dematteo, S Venneti, LWS Finley, C Lu, AR Judkins, ... Cell metabolism 22 (2), 304-311, 2015 | 468 | 2015 |
| Serine catabolism regulates mitochondrial redox control during hypoxia J Ye, J Fan, S Venneti, YW Wan, BR Pawel, J Zhang, LWS Finley, C Lu, ... Cancer discovery 4 (12), 1406-1417, 2014 | 435 | 2014 |
| Commensal bacteria make GPCR ligands that mimic human signalling molecules LJ Cohen, D Esterhazy, SH Kim, C Lemetre, RR Aguilar, EA Gordon, ... Nature 549 (7670), 48-53, 2017 | 421 | 2017 |
| Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion J Zhang, J Fan, S Venneti, JR Cross, T Takagi, B Bhinder, H Djaballah, ... Molecular cell 56 (2), 205-218, 2014 | 400 | 2014 |
| The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis EE Govek, SE Newey, CJ Akerman, JR Cross, L Van der Veken, ... Nature neuroscience 7 (4), 364-372, 2004 | 368 | 2004 |
| Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo S Venneti, MP Dunphy, H Zhang, KL Pitter, P Zanzonico, C Campos, ... Science translational medicine 7 (274), 274ra17-274ra17, 2015 | 312 | 2015 |
