| Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ... Cell 149 (3), 656-670, 2012 | 1995 | 2012 |
| Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway J Son, CA Lyssiotis, H Ying, X Wang, S Hua, M Ligorio, RM Perera, ... Nature 496 (7443), 101-105, 2013 | 1916 | 2013 |
| Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function A Viale, P Pettazzoni, CA Lyssiotis, H Ying, N Sánchez, M Marchesini, ... Nature 514 (7524), 628-632, 2014 | 1197 | 2014 |
| Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ... Nature genetics 43 (9), 869-874, 2011 | 1181 | 2011 |
| A colorectal cancer classification system that associates cellular phenotype and responses to therapy A Sadanandam, CA Lyssiotis, K Homicsko, EA Collisson, WJ Gibb, ... Nature medicine 19 (5), 619-625, 2013 | 1092 | 2013 |
| Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion CM Sousa, DE Biancur, X Wang, CJ Halbrook, MH Sherman, LI Zhang, ... Nature 536 (7617), 479-483, 2016 | 994 | 2016 |
| Cysteine depletion induces pancreatic tumor ferroptosis in mice MA Badgley, DM Kremer, HC Maurer, KE DelGiorno, HJ Lee, V Purohit, ... Science 368 (6486), 85-89, 2020 | 855 | 2020 |
| ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect W Yang, Y Zheng, Y Xia, H Ji, X Chen, F Guo, CA Lyssiotis, K Aldape, ... Nature cell biology 14 (12), 1295-1304, 2012 | 827 | 2012 |
| Metabolic interactions in the tumor microenvironment CA Lyssiotis, AC Kimmelman Trends in cell biology 27 (11), 863-875, 2017 | 713 | 2017 |
| Influence of threonine metabolism on S-adenosylmethionine and histone methylation N Shyh-Chang, JW Locasale, CA Lyssiotis, Y Zheng, RY Teo, ... Science 339 (6116), 222-226, 2013 | 663 | 2013 |
| Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor T Maj, W Wang, J Crespo, H Zhang, W Wang, S Wei, L Zhao, L Vatan, ... Nature immunology 18 (12), 1332-1341, 2017 | 590 | 2017 |
| Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer KL Bryant, CA Stalnecker, D Zeitouni, JE Klomp, S Peng, AP Tikunov, ... Nature medicine 25 (4), 628-640, 2019 | 581 | 2019 |
| A regenerative approach to the treatment of multiple sclerosis VA Deshmukh, V Tardif, CA Lyssiotis, CC Green, B Kerman, HJ Kim, ... Nature 502 (7471), 327-332, 2013 | 526 | 2013 |
| Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4 CA Lyssiotis, RK Foreman, J Staerk, M Garcia, D Mathur, S Markoulaki, ... Proceedings of the National Academy of Sciences 106 (22), 8912-8917, 2009 | 498 | 2009 |
| MUC1 and HIF-1alpha signaling crosstalk induces anabolic glucose metabolism to impart gemcitabine resistance to pancreatic cancer SK Shukla, V Purohit, K Mehla, V Gunda, NV Chaika, E Vernucci, RJ King, ... Cancer cell 32 (1), 71-87. e7, 2017 | 475 | 2017 |
| Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer A Juvekar, LN Burga, H Hu, EP Lunsford, YH Ibrahim, J Balmañà, ... Cancer discovery 2 (11), 1048-1063, 2012 | 459 | 2012 |
| Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton H Hu, A Juvekar, CA Lyssiotis, EC Lien, JG Albeck, D Oh, G Varma, ... Cell 164 (3), 433-446, 2016 | 360 | 2016 |
| Employing metabolism to improve the diagnosis and treatment of pancreatic cancer CJ Halbrook, CA Lyssiotis Cancer cell 31 (1), 5-19, 2017 | 358 | 2017 |
| Cancer SLC43A2 alters T cell methionine metabolism and histone methylation Y Bian, W Li, DM Kremer, P Sajjakulnukit, S Li, J Crespo, ZC Nwosu, ... Nature 585 (7824), 277-282, 2020 | 350 | 2020 |
| Macrophage-released pyrimidines inhibit gemcitabine therapy in pancreatic cancer CJ Halbrook, C Pontious, I Kovalenko, L Lapienyte, S Dreyer, HJ Lee, ... Cell metabolism 29 (6), 1390-1399. e6, 2019 | 345 | 2019 |
Lewis CantleyDana Farber Cancer Center and Harvard Medical School在 med.cornell.edu 的电子邮件经过验证
