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Aditi Madan
Aditi Madan
Staff Scientist, Fred Hutch Cancer Center
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Raman spectroscopic studies on screening of myopathies
R Gautam, S Vanga, A Madan, N Gayathri, U Nongthomba, S Umapathy
Analytical chemistry 87 (4), 2187-2194, 2015
372015
TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction
A Madan, MC Viswanathan, KC Woulfe, W Schmidt, A Sidor, T Liu, ...
Proceedings of the National Academy of Sciences 117 (31), 18822-18831, 2020
272020
Acoustotactic response of mosquitoes in untethered flight to incidental sound
Z Dou, A Madan, JS Carlson, J Chung, T Spoleti, G Dimopoulos, ...
Scientific reports 11 (1), 1884, 2021
212021
Overexpression of miRNA-9 Generates Muscle Hypercontraction Through Translational Repression of Troponin-T in Drosophila melanogaster Indirect Flight Muscles
P Katti, D Thimmaya, A Madan, U Nongthomba
G3: Genes, Genomes, Genetics 7 (10), 3521-3531, 2017
192017
A role for actin flexibility in thin filament-mediated contractile regulation and myopathy
MC Viswanathan, W Schmidt, P Franz, MJ Rynkiewicz, CS Newhard, ...
Nature communications 11 (1), 2417, 2020
172020
Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity
W Schmidt, A Madan, DB Foster, A Cammarato
Journal of Biological Chemistry 295 (46), 15527-15539, 2020
132020
Transcriptome analysis of IFM-specific actin and myosin nulls in Drosophila melanogaster unravels lesion-specific expression blueprints across muscle mutations
A Madan, D Thimmaiya, A Franco-Cea, M Aiyaz, P Kumar, JC Sparrow, ...
Gene 631, 16-28, 2017
32017
Nuclear retention of LEPTIN/UPD2 regulates organismal resilience to nutrient extremes
ME Poling, CE Sullivan, A Madan, KP Kelly, AE Brent, J Dubrulle, ...
22021
Myosin Transducer Inter-Strand Communication Is Critical for Normal ATPase Activity and Myofibril Structure
WA Kronert, KH Hsu, A Madan, F Sarsoza, A Cammarato, SI Bernstein
Biology 11 (8), 1137, 2022
12022
Act88F pseudo-acetylation of lysine 50 (K50) negatively regulates muscle function in Drosophila
L Godoy, A Lopez, T Stewart, A Madan, J Baker, A Cammarato, ...
Physiology 39 (S1), 2134, 2024
2024
TNNT2 mutations in the tropomyosin-binding segment of TNT1 engender dilated cardiomyopathy in Drosophila
A Madan, K Chitre, EA Brundage, BJ Biesiadecki, A Cammarato
Biophysical Journal 123 (3), 536a, 2024
2024
Atg8-LC3 controls systemic nutrient surplus signaling from flies to humans
A Madan, KP Kelly, CE Sullivan, ME Poling, AE Brent, M Alassaf, ...
bioRxiv, 2023.05. 31.543119, 2023
2023
A new tool for producing and investigating recombinant sarcomeric actin
A Madan, J Cossentino, MC Viswanathan, W Schmidt, A Fenwick, ...
Biophysical journal 122 (3), 27a-28a, 2023
2023
Skeletal muscle alpha actin (ACTA1) acetylation negatively regulates muscle function in response to obesity
A Lopez, S Romanick, T Stewart, A Madan, J Baker, A Cammarato, ...
The FASEB Journal 36, 2022
2022
Pseudo-acetylation of actin K326 and K328 increases duration and force of contraction in mouse cardiomyocytes
A Fenwick, VP Jani, A Madan, A Cammarato
Biophysical Journal 121 (3), 394a, 2022
2022
The ACTC A331P hypertrophic cardiomyopathy mutation enhances basal contractile activity and causes resting muscle dysfunction
M Doran, E Despond, M Viswanathan, A Madan, J Cossentino, ...
Biophysical Journal 121 (3), 108a, 2022
2022
Distinct Myocardial Gene Expression Signatures in Heart Failure with Preserved Ejection Fraction
VS Hahn, H Knutsdottir, A Madan, X Luo, K Bedi, KB Margulies, ...
Journal of Cardiac Failure 26 (10), S8-S9, 2020
2020
Mutations in the TnT1 Tropomyosin-Binding Element of Troponin-T Alter Its Inhibitory Properties and Stimulate Myocardial Dysfunction
A Madan, MC Viswanathan, KC Woulfe, WM Schmidt, G Vogler, C Wilson, ...
Biophysical Journal 118 (3), 423a, 2020
2020
Troponin-T Cardiomyopathy Mutations Depress its Inhibitory Properties, In Vitro, and Stimulate Myocardial Dysfunction, In Vivo
A Madan, MC Viswanathan, G Vogler, KC Woulfe, W Schmidt, B Trinh, ...
Biophysical Journal 116 (3), 114a, 2019
2019
Developmental and Functional Roles of Troponin-T Isoforms, and Exploring Genome-Wide Alterations in Drosophila Indirect Flight Muscle Mutants
A Madan
2018
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