| Maximizing synthetic efficiency: multi-component transformations lead the way H Bienayme, C Hulme, G Oddon, P Schmitt Chemistry - A European Journal 6 (18), 3321-29, 2000 | 1471 | 2000 |
| " Multi-component reactions: emerging chemistry in drug discovery"'from xylocain to crixivan' C Hulme, V Gore Current medicinal chemistry 10 (1), 51-80, 2003 | 1317 | 2003 |
| New 4-point pharmacophore method for molecular similarity and diversity applications: overview of the method and applications, including a novel approach to the design of … JS Mason, I Morize, PR Menard, DL Cheney, C Hulme, RF Labaudiniere Journal of medicinal chemistry 42 (17), 3251-3264, 1999 | 515 | 1999 |
| Hypervalent iodine chemistry: new oxidation reactions using the iodosylbenzene− trimethylsilyl azide reagent combination. Direct α-and β-azido functionalization of … P Magnus, J Lacour, PA Evans, MB Roe, C Hulme Journal of the American Chemical Society 118 (14), 3406-3418, 1996 | 193 | 1996 |
| The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: A structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796 J Dietrich, C Hulme, LH Hurley Bioorganic & medicinal chemistry 18 (15), 5738-5748, 2010 | 187 | 2010 |
| Novel safety-catch linker and its application with a Ugi/De-BOC/Cyclization (UDC) strategy to access carboxylic acids, 1, 4-benzodiazepines, diketopiperazines, ketopiperazines … C Hulme, J Peng, G Morton, JM Salvino, T Herpin, R Labaudiniere Tetrahedron letters 39 (40), 7227-7230, 1998 | 170 | 1998 |
| Novel applications of ethyl glyoxalate with the Ugi MCR C Hulme, MP Cherrier Tetrahedron letters 40 (29), 5295-5299, 1999 | 163 | 1999 |
| Improved procedure for the solution phase preparation of 1, 4-benzodiazepine-2, 5-dione libraries via Armstrong's convertible isonitrile and the Ugi reaction C Hulme, J Peng, SY Tang, CJ Burns, I Morize, R Labaudiniere The Journal of Organic Chemistry 63 (22), 8021-8023, 1998 | 157 | 1998 |
| Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry C Hulme, J Dietrich Molecular diversity 13, 195-207, 2009 | 156 | 2009 |
| Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer’s? B Smith, F Medda, V Gokhale, T Dunckley, C Hulme ACS chemical neuroscience 3 (11), 857-872, 2012 | 152 | 2012 |
| The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: novel application of Armstrong's convertible isonitrile C Hulme, MM Morrissette, FA Volz, CJ Burns Tetrahedron letters 39 (10), 1113-1116, 1998 | 151 | 1998 |
| Two-step solution-phase synthesis of novel benzimidazoles utilizing a UDC (Ugi/de-Boc/cyclize) strategy P Tempest, V Ma, S Thomas, Z Hua, MG Kelly, C Hulme Tetrahedron Letters 42 (30), 4959-4962, 2001 | 128 | 2001 |
| Ugi/Aldol Sequence: Expeditious Entry to Several Families of Densely Substituted Nitrogen Heterocycles. CH Z Xu, F De Moliner, AP Cappelli Angewandte Chemie, 8161-8164, 2012 | 116* | 2012 |
| Dyrk1 inhibition improves Alzheimer's disease‐like pathology C Branca, DM Shaw, R Belfiore, V Gokhale, AY Shaw, C Foley, B Smith, ... Aging cell 16 (5), 1146-1154, 2017 | 108 | 2017 |
| MCC/SNAr methodology. Part 1: Novel access to a range of heterocyclic cores P Tempest, V Ma, MG Kelly, W Jones, C Hulme Tetrahedron Letters 42 (30), 4963-4968, 2001 | 105 | 2001 |
| Emerging approaches for the syntheses of bicyclic imidazo [1, 2-x]-heterocycles C Hulme, YS Lee Molecular Diversity 12, 1-15, 2008 | 103 | 2008 |
| Two-step solution-phase synthesis of novel quinoxalinones utilizing a UDC (Ugi/de-Boc/cyclize) strategy T Nixey, P Tempest, C Hulme Tetrahedron letters 43 (9), 1637-1639, 2002 | 102 | 2002 |
| . alpha.-Azidonation of Amides, Carbamates, and Ureas with the Iodosylbenzene/Trimethylsilyl Azide Reagent Combination: N-Acyliminium Ion Precursors P Magnus, C Hulme, W Weber Journal of the American Chemical Society 116 (10), 4501-4502, 1994 | 102 | 1994 |
| Novel applications of carbon dioxide/MeOH for the synthesis of hydantoins and cyclic ureas via the Ugi reaction C Hulme, L Ma, JJ Romano, G Morton, SY Tang, MP Cherrier, S Choi, ... Tetrahedron Letters 41 (12), 1889-1893, 2000 | 99 | 2000 |
| Sequential Ugi/Strecker reactions via microwave assisted organic synthesis: novel 3-center-4-component and 3-center-5-component multi-component reactions T Masquelin, H Bui, B Brickley, G Stephenson, J Schwerkoske, C Hulme Tetrahedron letters 47 (17), 2989-2991, 2006 | 95 | 2006 |
Guillermo Martinez-ArizaUniversity of Arizona在 email.arizona.edu 的电子邮件经过验证
