| GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages S Maedera, T Mizuno, H Ishiguro, T Ito, T Soga, H Kusuhara FEBS letters 593 (2), 195-208, 2019 | 66 | 2019 |
| Ubiquitination is associated with lysosomal degradation of cell surface‐resident ATP‐binding cassette transporter A1 (ABCA1) through the endosomal sorting complex required for … T Mizuno, H Hayashi, S Naoi, Y Sugiyama Hepatology 54 (2), 631-643, 2011 | 44 | 2011 |
| 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration H Hayashi, T Mizuno, R Horikawa, H Nagasaka, T Yabuki, H Takikawa, ... Journal of hepatology 56 (5), 1136-1144, 2012 | 42 | 2012 |
| Involvement of organic cation transporters in the kinetics of trimethylamine N-oxide T Miyake, T Mizuno, T Mochizuki, M Kimura, S Matsuki, S Irie, I Ieiri, ... Journal of pharmaceutical sciences 106 (9), 2542-2550, 2017 | 39 | 2017 |
| Elucidation of N1-methyladenosine as a potential surrogate biomarker for drug interaction studies involving renal organic cation transporters T Miyake, T Mizuno, I Takehara, T Mochizuki, M Kimura, S Matsuki, S Irie, ... Drug Metabolism and Disposition 47 (11), 1270-1280, 2019 | 33 | 2019 |
| Cellular Cholesterol Accumulation Facilitates Ubiquitination and Lysosomal Degradation of Cell Surface–Resident ABCA1 T Mizuno, H Hayashi, H Kusuhara Arteriosclerosis, thrombosis, and vascular biology 35 (6), 1347-1356, 2015 | 33 | 2015 |
| Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo H Kuwahara, J Song, T Shimoura, K Yoshida-Tanaka, T Mizuno, ... Scientific reports 8 (1), 4377, 2018 | 31 | 2018 |
| Differential Roles of Ubiquitination in the Degradation Mechanism of Cell Surface–Resident Bile Salt Export Pump and Multidrug Resistance–Associated Protein 2 K Aida, H Hayashi, K Inamura, T Mizuno, Y Sugiyama Molecular pharmacology 85 (3), 482-491, 2014 | 28 | 2014 |
| Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development T Mochizuki, T Mizuno, K Maeda, H Kusuhara Drug Metabolism and Pharmacokinetics 37, 100358, 2021 | 22 | 2021 |
| Alteration in the plasma concentrations of endogenous organic anion–transporting polypeptide 1B biomarkers in patients with non–small cell lung cancer treated with paclitaxel D Mori, H Ishida, T Mizuno, S Kusumoto, Y Kondo, S Izumi, G Nakata, ... Drug Metabolism and Disposition 48 (5), 387-394, 2020 | 22 | 2020 |
| Evaluation of organic anion transporter 1A2-knock-in mice as a model of human blood-brain barrier Y Sano, T Mizuno, T Mochizuki, Y Uchida, M Umetsu, T Terasaki, ... Drug Metabolism and Disposition 46 (11), 1767-1775, 2018 | 21 | 2018 |
| Effect of cyclosporin A and impact of dose staggering on OATP1B1/1B3 endogenous substrates and drug probes for assessing clinical drug interactions T Mochizuki, MJ Zamek‐Gliszczynski, K Yoshida, J Mao, K Taskar, ... Clinical Pharmacology & Therapeutics 111 (6), 1315-1323, 2022 | 19 | 2022 |
| Functional investigation of solute carrier family 35, member F2, in three cellular models of the primate blood-brain barrier T Mochizuki, T Mizuno, T Kurosawa, T Yamaguchi, K Higuchi, Y Tega, ... Drug Metabolism and Disposition 49 (1), 3-11, 2021 | 16 | 2021 |
| Development of orthogonal linear separation analysis (OLSA) to decompose drug effects into basic components T Mizuno, S Kinoshita, T Ito, S Maedera, H Kusuhara Scientific Reports 9 (1), 1824, 2019 | 13 | 2019 |
| Decomposition profile data analysis for deep understanding of multiple effects of natural products S Nemoto, K Morita, T Mizuno, H Kusuhara Journal of Natural Products 84 (4), 1283-1293, 2021 | 10 | 2021 |
| Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor K Morita, T Mizuno, H Kusuhara Scientific Reports 10 (1), 13139, 2020 | 10 | 2020 |
| Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic … T Kito, S Ito, T Mizuno, K Maeda, H Kusuhara Drug Metabolism and Pharmacokinetics 34 (1), 87-94, 2019 | 9 | 2019 |
| Investigation of chemical structure recognition by encoder–decoder models in learning progress S Nemoto, T Mizuno, H Kusuhara Journal of Cheminformatics 15 (1), 45, 2023 | 8 | 2023 |
| Interesting properties of profile data analysis in the understanding and utilization of the effects of drugs T Mizuno, K Morita, H Kusuhara Biological and Pharmaceutical Bulletin 43 (10), 1435-1442, 2020 | 6 | 2020 |
| Investigation of a data split strategy involving the time axis in adverse event prediction using machine learning K Morita, T Mizuno, H Kusuhara Journal of Chemical Information and Modeling 62 (17), 3982-3992, 2022 | 5 | 2022 |
