Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation E Hirsch, VL Katanaev, C Garlanda, O Azzolino, L Pirola, L Silengo, ... Science 287 (5455), 1049-1053, 2000 | 1573 | 2000 |
Lipid signalling in disease MP Wymann, R Schneiter Nature reviews Molecular cell biology 9 (2), 162-176, 2008 | 1549 | 2008 |
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine EH Walker, ME Pacold, O Perisic, L Stephens, PT Hawkins, MP Wymann, ... Molecular cell 6 (4), 909-919, 2000 | 1516 | 2000 |
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses A Arcaro, MP Wymann Biochemical Journal 296 (2), 297-301, 1993 | 1461 | 1993 |
Structure and function of phosphoinositide 3-kinases MP Wymann, L Pirola Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 1998 | 926 | 1998 |
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction MP Wymann, G Bulgarelli-Leva, MJ Zvelebil, L Pirola, B Vanhaesebroeck, ... Molecular and cellular biology, 1996 | 906 | 1996 |
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis M Camps, T Rückle, H Ji, V Ardissone, F Rintelen, J Shaw, C Ferrandi, ... Nature medicine 11 (9), 936-943, 2005 | 904 | 2005 |
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways MA Crackower, GY Oudit, I Kozieradzki, R Sarao, H Sun, T Sasaki, ... Cell 110 (6), 737-749, 2002 | 795 | 2002 |
Targeting phosphoinositide 3-kinase—moving towards therapy R Marone, V Cmiljanovic, B Giese, MP Wymann Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1784 (1), 159-185, 2008 | 750 | 2008 |
PI3Kγ modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and-independent effects E Patrucco, A Notte, L Barberis, G Selvetella, A Maffei, M Brancaccio, ... Cell 118 (3), 375-387, 2004 | 605 | 2004 |
Phosphoinositide 3-kinase signalling–which way to target? MP Wymann, M Zvelebil, M Laffargue Trends in pharmacological sciences 24 (7), 366-376, 2003 | 595 | 2003 |
Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK T Bondeva, L Pirola, G Bulgarelli-Leva, I Rubio, R Wetzker, MP Wymann Science 282 (5387), 293-296, 1998 | 440 | 1998 |
Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons HY Man, Q Wang, WY Lu, W Ju, G Ahmadian, L Liu, S D'Souza, TP Wong, ... Neuron 38 (4), 611-624, 2003 | 439 | 2003 |
Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function M Laffargue, R Calvez, P Finan, A Trifilieff, M Barbier, F Altruda, E Hirsch, ... Immunity 16 (3), 441-451, 2002 | 392 | 2002 |
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils AM Condliffe, K Davidson, KE Anderson, CD Ellson, T Crabbe, ... Blood 106 (4), 1432-1440, 2005 | 386 | 2005 |
Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3‐kinase‐, rho‐, and rac‐dependent signaling pathways S Attoub, V Noe, L Pirola, E Bruyneel, E Chastre, M Mareel, MP Wymann, ... The FASEB Journal 14 (14), 2329-2338, 2000 | 328 | 2000 |
Turning on the respiratory burst M Baggiolini, MP Wymann Trends in biochemical sciences 15 (2), 69-72, 1990 | 302 | 1990 |
Phosphoinositide 3-kinase p110β activity: key role in metabolism and mammary gland cancer but not development E Ciraolo, M Iezzi, R Marone, S Marengo, C Curcio, C Costa, O Azzolino, ... Science signaling 1 (36), ra3-ra3, 2008 | 297 | 2008 |
PI (3) Kγ has an important context-dependent role in neutrophil chemokinesis GJ Ferguson, L Milne, S Kulkarni, T Sasaki, S Walker, S Andrews, ... Nature cell biology 9 (1), 86-91, 2007 | 297 | 2007 |
Resistance to thromboembolism in PI3Kγ‐deficient mice E Hirsch, O Bosco, P Tropel, M Laffargue, R Calvez, F Altruda, ... The FASEB Journal 15 (11), 2019-2021, 2001 | 279 | 2001 |