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Leon Smyth
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Brain pericytes as mediators of neuroinflammation
J Rustenhoven, D Jansson, LC Smyth, M Dragunow
Trends in pharmacological sciences 38 (3), 291-304, 2017
3362017
Markers for human brain pericytes and smooth muscle cells
LCD Smyth, J Rustenhoven, EL Scotter, P Schweder, RLM Faull, TIH Park, ...
Journal of chemical neuroanatomy 92, 48-60, 2018
2152018
PU. 1 regulates Alzheimer’s disease-associated genes in primary human microglia
J Rustenhoven, AM Smith, LC Smyth, D Jansson, EL Scotter, ...
Molecular neurodegeneration 13, 1-16, 2018
1272018
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
JA Mazzitelli, LCD Smyth, KA Cross, T Dykstra, J Sun, S Du, T Mamuladze, ...
Nature neuroscience 25 (5), 555-560, 2022
1242022
Unique and shared inflammatory profiles of human brain endothelia and pericytes
LCD Smyth, J Rustenhoven, TIH Park, P Schweder, D Jansson, ...
Journal of neuroinflammation 15, 1-18, 2018
1102018
Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease
LCD Smyth, HC Murray, M Hill, E van Leeuwen, B Highet, NJ Magon, ...
Acta neuropathologica communications 10 (1), 38, 2022
612022
Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis
MEV Swanson, EL Scotter, LCD Smyth, HC Murray, B Ryan, C Turner, ...
Acta Neuropathologica Communications 8, 1-16, 2020
592020
Interferon-γ blocks signalling through PDGFRβ in human brain pericytes
D Jansson, EL Scotter, J Rustenhoven, N Coppieters, LCD Smyth, ...
Journal of Neuroinflammation 13, 1-19, 2016
372016
Characterisation of PDGF-BB: PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
LCD Smyth, B Highet, D Jansson, J Wu, J Rustenhoven, M Aalderink, ...
Communications biology 5 (1), 235, 2022
352022
Single-cell image analysis reveals a protective role for microglia in glioblastoma
Z Woolf, MEV Swanson, LC Smyth, EW Mee, P Schweder, P Heppner, ...
Neuro-Oncology Advances 3 (1), vdab031, 2021
302021
Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
D Jansson, VB Dieriks, J Rustenhoven, LCD Smyth, E Scotter, ...
Communications Biology 4 (1), 260, 2021
252021
Redox signalling and regulation of the blood-brain barrier
E van Leeuwen, MB Hampton, LCD Smyth
The international journal of biochemistry & cell biology 125, 105794, 2020
242020
C9ORF72 and UBQLN2 mutations are causes of amyotrophic lateral sclerosis in New Zealand: a genetic and pathologic study using banked human brain tissue
EL Scotter, L Smyth, CH Wong, M de Majo, CA Vance, BJ Synek, C Turner, ...
Neurobiology of aging 49, 214. e1-214. e5, 2017
242017
Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction
J Rustenhoven, LC Smyth, D Jansson, P Schweder, M Aalderink, ...
BMC neuroscience 19, 1-15, 2018
232018
Routine culture and study of adult human brain cells from neurosurgical specimens
TIH Park, LCD Smyth, M Aalderink, ZR Woolf, J Rustenhoven, K Lee, ...
Nature Protocols 17 (2), 190-221, 2022
222022
Identification of direct connections between the dura and the brain
LCD Smyth, D Xu, SV Okar, T Dykstra, J Rustenhoven, Z Papadopoulos, ...
Nature 627 (8002), 165-173, 2024
192024
Isolation and culture of functional adult human neurons from neurosurgical brain specimens
TIH Park, P Schweder, K Lee, BV Dieriks, Y Jung, L Smyth, ...
Brain Communications 2 (2), fcaa171, 2020
192020
Mycobacterium smegmatis resists the bactericidal activity of hypochlorous acid produced in neutrophil phagosomes
HA Parker, N Dickerhof, L Forrester, H Ryburn, L Smyth, J Messens, ...
The Journal of Immunology 206 (8), 1901-1912, 2021
152021
Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils
L Schindler, LCD Smyth, J Bernhagen, MB Hampton, N Dickerhof
Redox biology 41, 101946, 2021
142021
Skull bone marrow channels as immune gateways to the central nervous system
JA Mazzitelli, FE Pulous, LCD Smyth, Z Kaya, J Rustenhoven, ...
Nature neuroscience 26 (12), 2052-2062, 2023
122023
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