| Discovery of a potent and specific M. tuberculosis Leucyl-tRNA synthetase inhibitor:(S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy) benzo [c][1, 2] oxaborol-1 (3 H)-ol (GSK656) X Li, V Hernandez, FL Rock, W Choi, YSL Mak, M Mohan, W Mao, Y Zhou, ... Journal of medicinal chemistry 60 (19), 8011-8026, 2017 | 150 | 2017 |
| Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase A Palencia, X Li, W Bu, W Choi, CZ Ding, EE Easom, L Feng, ... Antimicrobial agents and chemotherapy 60 (10), 6271-6280, 2016 | 112 | 2016 |
| A new ligation method for N-terminal tryptophan-containing peptides using the Pictet–Spengler reaction X Li, L Zhang, SE Hall, JP Tam Tetrahedron Letters 41 (21), 4069-4073, 2000 | 109 | 2000 |
| α, α-Difluoro-β-ketophosphonates as potent inhibitors of protein tyrosine phosphatase 1B X Li, A Bhandari, CP Holmes, AK Szardenings Bioorganic & medicinal chemistry letters 14 (16), 4301-4306, 2004 | 81 | 2004 |
| Antimalarial benzoxaboroles target Plasmodium falciparum leucyl-tRNA synthetase E Sonoiki, A Palencia, D Guo, V Ahyong, C Dong, X Li, VS Hernandez, ... Antimicrobial agents and chemotherapy 60 (8), 4886-4895, 2016 | 74 | 2016 |
| Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase A Palencia, RJ Liu, M Lukarska, J Gut, A Bougdour, B Touquet, ED Wang, ... Antimicrobial agents and chemotherapy 60 (10), 5817-5827, 2016 | 69 | 2016 |
| Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties X Li, S Zhang, YK Zhang, Y Liu, CZ Ding, Y Zhou, JJ Plattner, SJ Baker, ... Bioorganic & medicinal chemistry letters 21 (7), 2048-2054, 2011 | 62 | 2011 |
| Synthesis and evaluation of novel α-amino cyclic boronates as inhibitors of HCV NS3 protease X Li, YK Zhang, Y Liu, CZ Ding, Q Li, Y Zhou, JJ Plattner, SJ Baker, X Qian, ... Bioorganic & medicinal chemistry letters 20 (12), 3550-3556, 2010 | 59 | 2010 |
| Normal and abnormal protein subunit interactions in hemoglobins JM Manning, A Dumoulin, X Li, LR Manning Journal of Biological Chemistry 273 (31), 19359-19362, 1998 | 57 | 1998 |
| Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease CZ Ding, YK Zhang, X Li, Y Liu, S Zhang, Y Zhou, JJ Plattner, SJ Baker, ... Bioorganic & medicinal chemistry letters 20 (24), 7317-7322, 2010 | 54 | 2010 |
| Discovery and structure–activity relationships of novel sulfonamides as potent PTP1B inhibitors CP Holmes, X Li, Y Pan, C Xu, A Bhandari, CM Moody, JA Miguel, ... Bioorganic & medicinal chemistry letters 15 (19), 4336-4341, 2005 | 53 | 2005 |
| Chroman derivatives B Wang, G Walkinshaw, S Boddupalli, AM Elizarov, X Jin, X Li, DR James, ... US Patent 7,514,461, 2009 | 52 | 2009 |
| Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates X Li, YK Zhang, Y Liu, CZ Ding, Y Zhou, Q Li, JJ Plattner, SJ Baker, ... Bioorganic & medicinal chemistry letters 20 (19), 5695-5700, 2010 | 48 | 2010 |
| Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants WM Kazmierski, R Hamatake, M Duan, LL Wright, GK Smith, RL Jarvest, ... Journal of medicinal chemistry 55 (7), 3021-3026, 2012 | 45 | 2012 |
| Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis RT Jacobs, CS Lunde, YR Freund, V Hernandez, X Li, Y Xia, DS Carter, ... Journal of medicinal chemistry 62 (5), 2521-2540, 2019 | 44 | 2019 |
| Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone X Li, YK Zhang, JJ Plattner, W Mao, MRK Alley, Y Xia, V Hernandez, ... Bioorganic & medicinal chemistry letters 23 (4), 963-966, 2013 | 42 | 2013 |
| Solid-phase synthesis of 1, 2, 3, 4-tetrahydro-β-carboline-containing peptidomimetics X Li, L Zhang, W Zhang, SE Hall, JP Tam Organic Letters 2 (20), 3075-3078, 2000 | 41 | 2000 |
| Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease X Li, YK Zhang, Y Liu, S Zhang, CZ Ding, Y Zhou, JJ Plattner, SJ Baker, ... Bioorganic & medicinal chemistry letters 20 (24), 7493-7497, 2010 | 39 | 2010 |
| PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold CP Holmes, X Li, Y Pan, C Xu, A Bhandari, CM Moody, JA Miguel, ... Bioorganic & medicinal chemistry letters 18 (8), 2719-2724, 2008 | 38 | 2008 |
| d-Ala–dX ligases: evaluation of d-alanyl phosphate intermediate by MIX, PIX and rapid quench studies VL Healy, LS Mullins, X Li, SE Hall, FM Raushel, CT Walsh Chemistry & Biology 7 (7), 505-514, 2000 | 36 | 2000 |
Wieslaw ('Wes') KazmierskiBiohaven Pharmaceuticals在 biohavenpharma.com 的电子邮件经过验证
