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Lejla Medzikovic
Lejla Medzikovic
Postdoctoral researcher, UCLA David Geffen School of Medicine
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Nuclear receptor Nur77 limits the macrophage inflammatory response through transcriptional reprogramming of mitochondrial metabolism
DS Koenis, L Medzikovic, PB van Loenen, M van Weeghel, S Huveneers, ...
Cell reports 24 (8), 2127-2140. e7, 2018
1232018
Pulmonary hypertension secondary to pulmonary fibrosis: clinical data, histopathology and molecular insights
G Ruffenach, J Hong, M Vaillancourt, L Medzikovic, M Eghbali
Respiratory research 21, 1-14, 2020
572020
Single-cell study of two rat models of pulmonary arterial hypertension reveals connections to human pathobiology and drug repositioning
J Hong, D Arneson, S Umar, G Ruffenach, CM Cunningham, IS Ahn, ...
American journal of respiratory and critical care medicine 203 (8), 1006-1022, 2021
492021
Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines
CM Cunningham, M Li, G Ruffenach, M Doshi, L Aryan, J Hong, J Park, ...
American journal of respiratory and critical care medicine 206 (2), 186-196, 2022
472022
Connecting sex differences, estrogen signaling, and microRNAs in cardiac fibrosis
L Medzikovic, L Aryan, M Eghbali
Journal of Molecular Medicine 97, 1385-1398, 2019
462019
The role of microRNAs in acute respiratory distress syndrome and sepsis, from targets to therapies: a narrative review
LK Lee, L Medzikovic, M Eghbali, HK Eltzschig, X Yuan
Anesthesia & Analgesia 131 (5), 1471-1484, 2020
412020
Sex differences underlying preexisting cardiovascular disease and cardiovascular injury in COVID-19
L Medzikovic, CM Cunningham, M Li, M Amjedi, J Hong, G Ruffenach, ...
Journal of Molecular and Cellular Cardiology 148, 25-33, 2020
372020
Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling
L Medzikovic, CA Schumacher, AO Verkerk, ED van Deel, R Wolswinkel, ...
Scientific reports 5 (1), 15404, 2015
372015
NR4A nuclear receptors in cardiac remodeling and neurohormonal regulation
L Medzikovic, CJM de Vries, V de Waard
Trends in cardiovascular medicine 29 (8), 429-437, 2019
362019
Role of miRNA-1 and miRNA-21 in acute myocardial ischemia-reperfusion injury and their potential as therapeutic strategy
E Jayawardena, L Medzikovic, G Ruffenach, M Eghbali
International journal of molecular sciences 23 (3), 1512, 2022
292022
Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension
T Palao, L Medzikovic, C Rippe, S Wanga, C Al-Mardini, A van Weert, ...
Cardiovascular Pathology 35, 12-19, 2018
272018
Nur77 protects against adverse cardiac remodelling by limiting neuropeptide Y signalling in the sympathoadrenal-cardiac axis
L Medzikovic, C van Roomen, A Baartscheer, PB van Loenen, J de Vos, ...
Cardiovascular research 114 (12), 1617-1628, 2018
232018
Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs
L Aryan, L Medzikovic, S Umar, M Eghbali
Biology of sex Differences 11, 1-17, 2020
202020
Nuclear receptor Nur77 controls cardiac fibrosis through distinct actions on fibroblasts and cardiomyocytes
L Medzikovic, H Heese, PB van Loenen, CPAA van Roomen, ...
International journal of molecular sciences 22 (4), 1600, 2021
172021
HNRNPA2B1: RNA-binding protein that orchestrates smooth muscle cell phenotype in pulmonary arterial hypertension
G Ruffenach, L Medzikovic, L Aryan, M Li, M Eghbali
Circulation 146 (16), 1243-1258, 2022
142022
Overexpression of nitric oxide synthase restores circulating angiogenic cell function in patients with coronary artery disease: implications for autologous cell therapy for …
Q Chen, M Varga, X Wang, DJ Haddad, S An, L Medzikovic, ...
Journal of the American Heart Association 5 (1), e002257, 2016
142016
Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans
DS Koenis, L Medzikovic, M Vos, TJ Beldman, PB van Loenen, ...
Journal of Biological Chemistry 293 (39), 15070-15083, 2018
132018
Myocardial fibrosis and calcification are attenuated by microRNA–129-5p targeting Asporin and Sox9 in cardiac fibroblasts
L Medzikovic, L Aryan, G Ruffenach, M Li, N Savalli, W Sun, S Sarji, ...
JCI insight 8 (9), 2023
62023
Experimental pulmonary hypertension is associated with neuroinflammation in the spinal cord
M Vaillancourt, P Chia, L Medzikovic, N Cao, G Ruffenach, D Younessi, ...
Frontiers in Physiology 10, 1186, 2019
62019
Sex differences in therapies against myocardial ischemia-reperfusion injury: from basic science to clinical perspectives
L Medzikovic, T Azem, W Sun, P Rejali, L Esdin, S Rahman, ...
Cells 12 (16), 2077, 2023
52023
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