Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor EA Fink*, J Xu*, H Hübner*, JM Braz*, P Seemann*, C Avet, V Craik, ... Science 377 (6614), eabn7065, 2022 | 76 | 2022 |
Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine D Yuan, Z Liu, J Kaindl, S Maeda, J Zhao, X Sun, J Xu, P Gmeiner, ... Nature chemical biology 16 (5), 507-512, 2020 | 73 | 2020 |
Conformational complexity and dynamics in a muscarinic receptor revealed by NMR spectroscopy J Xu, Y Hu, J Kaindl, P Risel, H Hübner, S Maeda, X Niu, H Li, P Gmeiner, ... Molecular cell 75 (1), 53-65. e7, 2019 | 70 | 2019 |
Analysis of β2AR-Gs and β2AR-Gi complex formation by NMR spectroscopy X Ma, Y Hu, H Batebi, J Heng, J Xu, X Liu, X Niu, H Li, PW Hildebrand, ... Proceedings of the National Academy of Sciences 117 (37), 23096-23105, 2020 | 69 | 2020 |
Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor M Korczynska, MJ Clark, C Valant, J Xu, EV Moo, S Albold, DR Weiss, ... Proceedings of the National Academy of Sciences 115 (10), E2419-E2428, 2018 | 66 | 2018 |
Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family HR Kim*, J Xu*, S Maeda, NM Duc, D Ahn, Y Du, KY Chung Nature Communications 11 (1), 3160, 2020 | 48 | 2020 |
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex S Maeda, J Xu, FM N. Kadji, MJ Clark, J Zhao, N Tsutsumi, J Aoki, ... Science 369 (6500), 161-167, 2020 | 39 | 2020 |
Cryo-EM structure of the AVP–vasopressin receptor 2–Gs signaling complex L Wang*, J Xu*, S Cao, D Sun, H Liu, Q Lu, Z Liu, Y Du, C Zhang Cell Research 31 (8), 932-934, 2021 | 28 | 2021 |
Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex G Chen*, J Xu*, A Inoue, MF Schmidt, C Bai, Q Lu, P Gmeiner, Z Liu, Y Du Nature communications 13 (1), 2375, 2022 | 19 | 2022 |
Structural insights into ligand recognition, activation, and signaling of the α2A adrenergic receptor J Xu, S Cao, H Hübner, D Weikert, G Chen, Q Lu, D Yuan, P Gmeiner, ... Science advances 8 (9), eabj5347, 2022 | 16 | 2022 |
Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor J Xu, Q Wang, H Hübner, Y Hu, X Niu, H Wang, S Maeda, A Inoue, Y Tao, ... Nature Communications 14 (1), 376, 2023 | 15 | 2023 |
Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR J Xu, G Chen, H Wang, S Cao, J Heng, X Deupi, Y Du, BK Kobilka BioRxiv, 2022.03. 27.485993, 2022 | 8 | 2022 |
Step-wise activation of a Family C GPCR KK Kumar, H Wang, C Habrian, NR Latorraca, J Xu, ES O’Brien, C Zhang, ... Biorxiv, 2023 | 3 | 2023 |
Gαs slow conformational transition upon GTP binding and a novel Gαs regulator D Ahn, D Provasi, NM Duc, J Xu, L Salas-Estrada, A Spasic, MW Yun, ... Iscience 26 (5), 2023 | 3 | 2023 |
Structural and functional characterization of the endogenous agonist for orphan receptor GPR3 G Chen, N Staffen, Z Wu, X Xu, J Pan, A Inoue, T Shi, P Gmeiner, Y Du, ... Cell Research 34 (3), 262-265, 2024 | 2 | 2024 |
An allosteric ligand stabilizes distinct conformations in the M2 muscarinic acetylcholine receptor J Xu, H Hübner, Y Hu, X Niu, P Gmeiner, C Jin, B Kobilka bioRxiv, 2021.02. 14.431178, 2021 | 2 | 2021 |
Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq D Ham, A Inoue, J Xu, Y Du, KY Chung Communications Biology 7 (1), 362, 2024 | 1 | 2024 |
Stepwise activation of a metabotropic glutamate receptor K Krishna Kumar, H Wang, C Habrian, NR Latorraca, J Xu, ES O’Brien, ... Nature, 1-6, 2024 | | 2024 |
Author Correction: Cryo-EM structure of the AVP–vasopressin receptor 2–Gs signaling complex L Wang, J Xu, S Cao, D Sun, H Liu, Q Lu, Z Liu, Y Du, C Zhang Cell Research 32 (10), 957, 2022 | | 2022 |
Long-lived conformational changes in active Gsα revealed in atomistic detail by integrating HDX-MS with enhanced molecular dynamics simulations D Provasi, A Spasic, NM Duc, Y Du, D Ahn, J Xu, KY Chung, M Filizola Biophysical Journal 121 (3), 145a, 2022 | | 2022 |