关注
Iñigo Angulo-Barturen
Iñigo Angulo-Barturen
The Art of Discovery, SL
在 tad-med.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Chemical genetics of Plasmodium falciparum
WA Guiguemde, AA Shelat, D Bouck, S Duffy, GJ Crowther, PH Davis, ...
Nature 465 (7296), 311-315, 2010
6592010
A novel multiple-stage antimalarial agent that inhibits protein synthesis
B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ...
Nature 522 (7556), 315-320, 2015
4652015
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
MA Phillips, J Lotharius, K Marsh, J White, A Dayan, KL White, ...
Science translational medicine 7 (296), 296ra111-296ra111, 2015
3422015
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors …
JM Coteron, M Marco, J Esquivias, X Deng, KL White, J White, M Koltun, ...
Journal of medicinal chemistry 54 (15), 5540-5561, 2011
3282011
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium
MB Jiménez-Díaz, D Ebert, Y Salinas, A Pradhan, AM Lehane, ...
Proceedings of the National Academy of Sciences 111 (50), E5455-E5462, 2014
2812014
Cytokines in the pathogenesis of and protection against malaria
I Angulo, M Fresno
Clinical and Vaccine Immunology 9 (6), 1145-1152, 2002
2702002
Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis
SG Franzblau, MA DeGroote, SH Cho, K Andries, E Nuermberger, ...
Tuberculosis 92 (6), 453-488, 2012
2642012
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ...
Science translational medicine 9 (387), eaad9735, 2017
2602017
Quinolone-3-diarylethers: a new class of antimalarial drug
A Nilsen, AN LaCrue, KL White, IP Forquer, RM Cross, J Marfurt, ...
Science translational medicine 5 (177), 177ra37-177ra37, 2013
2552013
Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγnull Mice Engrafted with Human …
MB Jiménez-Díaz, T Mulet, S Viera, V Gómez, H Garuti, J Ibánez, ...
Antimicrobial agents and chemotherapy 53 (10), 4533-4536, 2009
2162009
Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in …
I Angulo, FG De Las Heras, JF Garcıa-Bustos, D Gargallo, ...
Blood, The Journal of the American Society of Hematology 95 (1), 212-220, 2000
2132000
A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes
I Angulo-Barturen, MB Jiménez-Díaz, T Mulet, J Rullas, E Herreros, ...
PloS one 3 (5), e2252, 2008
1972008
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum
AB Vaidya, JM Morrisey, Z Zhang, S Das, TM Daly, TD Otto, NJ Spillman, ...
Nature communications 5 (1), 5521, 2014
1582014
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model
ML Booker, CM Bastos, ML Kramer, RH Barker, R Skerlj, AB Sidhu, ...
Journal of Biological Chemistry 285 (43), 33054-33064, 2010
1582010
Discovery of a potent and specific M. tuberculosis Leucyl-tRNA synthetase inhibitor:(S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy) benzo [c][1, 2] oxaborol-1 (3 H)-ol (GSK656)
X Li, V Hernandez, FL Rock, W Choi, YSL Mak, M Mohan, W Mao, Y Zhou, ...
Journal of medicinal chemistry 60 (19), 8011-8026, 2017
1512017
Tetrahydropyrazolo [1, 5-a] pyrimidine-3-carboxamide and N-benzyl-6′, 7′-dihydrospiro [piperidine-4, 4′-thieno [3, 2-c] pyran] analogues with bactericidal efficacy against …
MJ Remuiñán, E Pérez-Herrán, J Rullás, C Alemparte, M Martínez-Hoyos, ...
PloS one 8 (4), e60933, 2013
1512013
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
DA Baker, LB Stewart, JM Large, PW Bowyer, KH Ansell, ...
Nature communications 8 (1), 430, 2017
1372017
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium …
L Encinas, H O’Keefe, M Neu, MJ Remuiñán, AM Patel, A Guardia, ...
Journal of Medicinal Chemistry 57 (4), 1276-1288, 2014
1232014
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B Baragaña, B Forte, R Choi, S Nakazawa Hewitt, JA Bueren-Calabuig, ...
Proceedings of the National Academy of Sciences 116 (14), 7015-7020, 2019
1192019
Pharmacokinetic-pharmacodynamic and dose-response relationships of antituberculosis drugs: recommendations and standards for industry and academia
T Gumbo, I Angulo-Barturen, S Ferrer-Bazaga
The Journal of infectious diseases 211 (suppl_3), S96-S106, 2015
1192015
系统目前无法执行此操作,请稍后再试。
文章 1–20