| Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis SY Jun, AJ Brown, NK Chua, JY Yoon, JJ Lee, JOK Yang, IS Jang, ... Gastroenterology 160 (4), 1194-1207. e28, 2021 | 94 | 2021 |
| Cholesterol homeostasis: How do cells sense sterol excess? V Howe, LJ Sharpe, SJ Alexopoulos, SV Kunze, NK Chua, D Li, AJ Brown Chemistry and physics of lipids 199, 170-178, 2016 | 77 | 2016 |
| Squalene monooxygenase: a journey to the heart of cholesterol synthesis NK Chua, HW Coates, AJ Brown Progress in Lipid Research 79, 101033, 2020 | 70 | 2020 |
| A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate H Yoshioka, HW Coates, NK Chua, Y Hashimoto, AJ Brown, K Ohgane Proceedings of the National Academy of Sciences 117 (13), 7150-7158, 2020 | 65 | 2020 |
| A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis NK Chua, V Howe, N Jatana, L Thukral, AJ Brown Journal of Biological Chemistry 292 (49), 19959-19973, 2017 | 63 | 2017 |
| The shape of human squalene epoxidase expands the arsenal against cancer AJ Brown, NK Chua, N Yan Nature communications 10 (1), 888, 2019 | 57 | 2019 |
| The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change V Howe, NK Chua, J Stevenson, AJ Brown Journal of Biological Chemistry 290 (46), 27533-27544, 2015 | 47 | 2015 |
| Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase NK Chua, G Hart-Smith, AJ Brown Journal of Biological Chemistry 294 (20), 8134-8147, 2019 | 40 | 2019 |
| Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency SA Hughes, M Lin, A Weir, B Huang, L Xiong, NK Chua, J Pang, ... The EMBO Journal 42 (5), e110468, 2023 | 20 | 2023 |
| Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron NK Chua, NA Scott, AJ Brown Biochemical Journal 476 (18), 2545-2560, 2019 | 16 | 2019 |
| Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms C Grohmann, CM Magtoto, JR Walker, NK Chua, A Gabrielyan, M Hall, ... Nature Communications 13 (1), 1-13, 2022 | 15 | 2022 |
| Cholesterol, cancer, and rebooting a treatment for athlete’s foot NK Chua, HW Coates, AJ Brown Science translational medicine 10 (437), 2018 | 14 | 2018 |
| Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene HW Coates, NK Chua, AJ Brown Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2019 | 11 | 2019 |
| Epithelial-to-mesenchymal transition supports ovarian carcinosarcoma tumorigenesis and confers sensitivity to microtubule-targeting with eribulin GY Ho, EL Kyran, J Bedo, MJ Wakefield, DP Ennis, HB Mirza, ... Cancer research, CAN-21-4012, 2022 | 9 | 2022 |
| Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24‐dehydro‐cholesterol reductase P Simonen, S Li, NK Chua, AM Lampi, V Piironen, J Lommi, J Sinisalo, ... Journal of Internal Medicine, 2020 | 9 | 2020 |
| Mallostery: Filling a niche between quality and metabolic control NK Chua, AJ Brown Journal of Biological Chemistry 293 (38), 14951-14952, 2018 | 5 | 2018 |
| The degron architecture of squalene monooxygenase and how specific lipids calibrate levels of this key cholesterol synthesis enzyme NK Chua, AJ Brown Protein Reviews: Volume 21, 1-12, 2021 | 2 | 2021 |
| Lipid sensing tips the balance for a key cholesterol synthesis enzyme NK Chua, AJ Brown Journal of Lipid Research 61 (11), 1363, 2020 | | 2020 |
| Regulated protein degradation and lipid sensing: Lessons from a key cholesterol synthesis enzyme NK Chua, AJ Brown 第三届中国生物物理学会代谢生物学分会学术研讨会论文集, 2019 | | 2019 |
