Combination approaches to combat multidrug-resistant bacteria RJ Worthington, C Melander Trends in biotechnology 31 (3), 177-184, 2013 | 692 | 2013 |
Small molecule control of bacterial biofilms RJ Worthington, JJ Richards, C Melander Organic & biomolecular chemistry 10 (37), 7457-7474, 2012 | 355 | 2012 |
Overcoming resistance to β-lactam antibiotics RJ Worthington, C Melander The Journal of organic chemistry 78 (9), 4207-4213, 2013 | 275 | 2013 |
Narrow-spectrum antibacterial agents RJ Melander, DV Zurawski, C Melander Medchemcomm 9 (1), 12-21, 2018 | 234 | 2018 |
The challenge of overcoming antibiotic resistance: an adjuvant approach? RJ Melander, C Melander ACS infectious diseases 3 (8), 559-563, 2017 | 213 | 2017 |
Biologically inspired strategies for combating bacterial biofilms MS Blackledge, RJ Worthington, C Melander Current opinion in pharmacology 13 (5), 699-706, 2013 | 180 | 2013 |
Endothelial C-type natriuretic peptide maintains vascular homeostasis AJ Moyes, RS Khambata, I Villar, KJ Bubb, RS Baliga, NG Lumsden, ... The Journal of clinical investigation 124 (9), 4039-4051, 2014 | 166 | 2014 |
Controlling bacterial behavior with indole-containing natural products and derivatives RJ Melander, MJ Minvielle, C Melander Tetrahedron 70 (37), 6363-6372, 2014 | 133 | 2014 |
Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence RJ Worthington, MS Blackledge, C Melander Future medicinal chemistry 5 (11), 1265-1284, 2013 | 116 | 2013 |
A new small molecule specifically inhibits the cariogenic bacterium Streptococcus mutans in multispecies biofilms C Liu, RJ Worthington, C Melander, H Wu Antimicrobial agents and chemotherapy 55 (6), 2679-2687, 2011 | 103 | 2011 |
Natural products as inspiration for the development of bacterial antibiofilm agents RJ Melander, AK Basak, C Melander Natural product reports 37 (11), 1454-1477, 2020 | 100 | 2020 |
Small molecule downregulation of PmrAB reverses lipid A modification and breaks colistin resistance TL Harris, RJ Worthington, LE Hittle, DV Zurawski, RK Ernst, C Melander ACS chemical biology 9 (1), 122-127, 2014 | 85 | 2014 |
Nanoscale structure–activity relationships, mode of action, and biocompatibility of gold nanoparticle antibiotics J Bresee, CM Bond, RJ Worthington, CA Smith, JC Gifford, CA Simpson, ... Journal of the American Chemical Society 136 (14), 5295-5300, 2014 | 84 | 2014 |
Potent Small‐Molecule Suppression of Oxacillin Resistance in Methicillin‐Resistant Staphylococcus aureus TL Harris, RJ Worthington, C Melander Angewandte Chemie International Edition 51 (45), 11254-11257, 2012 | 82 | 2012 |
Intercepting bacterial indole signaling with flustramine derivatives CA Bunders, MJ Minvielle, RJ Worthington, M Ortiz, J Cavanagh, ... Journal of the American Chemical Society 133 (50), 20160-20163, 2011 | 61 | 2011 |
Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae RJ Worthington, CA Bunders, CS Reed, C Melander ACS medicinal chemistry letters 3 (5), 357-361, 2012 | 60 | 2012 |
Meridianin D analogues display antibiofilm activity against MRSA and increase Colistin efficacy in gram-negative bacteria WM Huggins, WT Barker, JT Baker, NA Hahn, RJ Melander, C Melander ACS Medicinal Chemistry Letters 9 (7), 702-707, 2018 | 56 | 2018 |
Evaluation of 4,5‐Disubstituted‐2‐Aminoimidazole–Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii Z Su, L Peng, RJ Worthington, C Melander ChemMedChem 6 (12), 2243-2251, 2011 | 52 | 2011 |
N-substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1, 3-bis (tert-butoxycarbonyl) guanidine cyclization AA Yeagley, Z Su, KD McCullough, RJ Worthington, C Melander Organic & biomolecular chemistry 11 (1), 130-137, 2013 | 47 | 2013 |
Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules DF Ackart, EA Lindsey, BK Podell, RJ Melander, RJ Basaraba, ... Pathogens and disease 70 (3), 370-378, 2014 | 44 | 2014 |