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Brennen Heames
Brennen Heames
Optellum
在 optellum.com 的电子邮件经过验证
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Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis
S Emond, M Petek, EJ Kay, B Heames, SRA Devenish, N Tokuriki, ...
Nature communications 11 (1), 3469, 2020
642020
A continuum of evolving de novo genes drives protein-coding novelty in Drosophila
B Heames, J Schmitz, E Bornberg-Bauer
Journal of molecular evolution 88 (4), 382-398, 2020
602020
Structural and functional characterization of a putative de novo gene in Drosophila
A Lange, PH Patel, B Heames, AM Damry, T Saenger, CJ Jackson, ...
Nature communications 12 (1), 1667, 2021
412021
Experimental characterization of de novo proteins and their unevolved random-sequence counterparts
B Heames, F Buchel, M Aubel, V Tretyachenko, D Loginov, P Novák, ...
Nature ecology & evolution 7 (4), 570-580, 2023
302023
Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates
L Moretto, S Vance, B Heames, RW Broadhurst
Chemical Communications 53 (83), 11457-11460, 2017
172017
Becoming a de novo gene
E Bornberg-Bauer, B Heames
Nature Ecology & Evolution 3 (4), 524-525, 2019
92019
High-throughput Selection of Human de novo-emerged sORFs with High Folding Potential
M Aubel, F Buchel, B Heames, A Jones, O Honc, E Bornberg-Bauer, ...
Genome Biology and Evolution 16 (4), evae069, 2024
12024
Exploring the Potential of de Novo Gene Emergence to Support Protein-coding Evolutionary Novelty
B Heames
Westfälische Wilhelms-Universität Münster, 2023
2023
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