| Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features Y Shimmyo, T Kihara, A Akaike, T Niidome, H Sugimoto Biochimica et Biophysica Acta (BBA)-General Subjects 1780 (5), 819-825, 2008 | 263 | 2008 |
| Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation Y Shimmyo, T Kihara, A Akaike, T Niidome, H Sugimoto Neuroreport 19 (13), 1329-1333, 2008 | 145 | 2008 |
| Multifunction of myricetin on Aβ: neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases Y Shimmyo, T Kihara, A Akaike, T Niidome, H Sugimoto Journal of neuroscience research 86 (2), 368-377, 2008 | 144 | 2008 |
| Three distinct neuroprotective functions of myricetin against glutamate‐induced neuronal cell death: involvement of direct inhibition of caspase‐3 Y Shimmyo, T Kihara, A Akaike, T Niidome, H Sugimoto Journal of neuroscience research 86 (8), 1836-1845, 2008 | 101 | 2008 |
| Distinct mechanisms underlie distinct polyphenol-induced neuroprotection K Yazawa, T Kihara, H Shen, Y Shimmyo, T Niidome, H Sugimoto FEBS letters 580 (28-29), 6623-6628, 2006 | 89 | 2006 |
| Age-related changes of alpha-crystallin aggregate in human lens N Fujii, Y Shimmyo, M Sakai, Y Sadakane, T Nakamura, Y Morimoto, ... Amino acids 32, 87-94, 2007 | 53 | 2007 |
| Curcumin derivative T Takahashi, I Hijikuro, H Sugimoto, T Kihara, Y Shimmyo, T Niidome US Patent 8,962,674, 2015 | 31 | 2015 |
| SUN11602, a novel aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor N Murayama, T Kadoshima, N Takemoto, S Kodama, T Toba, R Ogino, ... ACS chemical neuroscience 4 (2), 266-276, 2013 | 13 | 2013 |
| Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2 T Kihara, Y Shimmyo, A Akaike, T Niidome, H Sugimoto Biochemical and biophysical research communications 393 (4), 728-733, 2010 | 13 | 2010 |
| Systemic treatment with a novel basic fibroblast growth factor mimic small-molecule compound boosts functional recovery after spinal cord injury S Imagama, R Ogino, S Ueno, N Murayama, N Takemoto, Y Shimmyo, ... PLoS One 15 (7), e0236050, 2020 | 12 | 2020 |
| Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy R Kuwayama, K Suzuki, J Nakamura, E Aizawa, Y Yoshioka, M Ikawa, ... Nature Communications 13 (1), 3107, 2022 | 10 | 2022 |
| Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential H Sakai, H Inoue, K Murata, T Toba, Y Shimmyo, N Narii, S Ueno, Y Igawa, ... Bioorganic & Medicinal Chemistry 28 (14), 115562, 2020 | 7 | 2020 |
| Discovery of 1, 2, 3-triazole-based fibroblast growth factor receptor modulators H Sakai, H Inoue, T Toba, K Murata, N Narii, Y Shimmyo, Y Igawa, ... Bioorganic & Medicinal Chemistry Letters 29 (16), 2332-2337, 2019 | 6 | 2019 |
| Synthesis and evaluation of N-(4-benzylphenyl) piperazines as VGF inducers T Toba, R Suzuki, J Futamura-Takahashi, Y Kawamoto, S Tamura, ... Bioorganic & Medicinal Chemistry Letters 28 (14), 2528-2532, 2018 | 1 | 2018 |
| Signaling pathway of SUN13837, a novel compound mimicking the pharmacological actions of bFGF Y Shimmyo, T Kadoshima, M Kuroda, R Ogino, T Masuda, N Murayama, ... JOURNAL OF PHARMACOLOGICAL SCIENCES 118, 182P-182P, 2012 | | 2012 |
| SUN13837, a novel small molecular compound shows bFGF-like neuroprotective action without cell proliferation Y Shimmyo, T Kadoshima, M Kuroda, R Ogino, T Masuda, N Murayama, ... JOURNAL OF PHARMACOLOGICAL SCIENCES 115, 241P-241P, 2011 | | 2011 |
| Flavonols and flavones as BACE-1 inhibitors: Structure-activity relationship in cell-free, cell-based and in silico studies reveal pharmacophore features Y Shimmyo, T Kihara, A Akaike, T Niidome, H Sugimoto JOURNAL OF PHARMACOLOGICAL SCIENCES 106, 183P-183P, 2008 | | 2008 |
| Neuroprotective effect of natural flavonoid myricetin against A beta 1-42-induced neurotoxicity: Protection at various toxic steps Y Shimmyo, T Kihara, T Niidome, H Sugimoto JOURNAL OF PHARMACOLOGICAL SCIENCES 103, 188P-188P, 2007 | | 2007 |
| The differenciatl sensitivity of lens alpha A-and alpha B-crystallin to UV B irradiation N FUJII, Y SHIMMYO, M SAKAI, Y GOTO, Y SADAKANE, T KINOUCHI, ... The Japan Radiation Research Society Annual Meeting Abstracts The 48th …, 2005 | | 2005 |
