An important role of Nrf2-ARE pathway in the cellular defense mechanism JM Lee, JA Johnson BMB Reports 37 (2), 139-143, 2004 | 944 | 2004 |
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis JM Lee, MJ Calkins, K Chan, YW Kan, JA Johnson Journal of Biological Chemistry 278 (14), 12029-12038, 2003 | 940 | 2003 |
Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress AY Shih, DA Johnson, G Wong, AD Kraft, L Jiang, H Erb, JA Johnson, ... Journal of Neuroscience 23 (8), 3394-3406, 2003 | 895 | 2003 |
The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration JA Johnson, DA Johnson, AD Kraft, MJ Calkins, RJ Jakel, MR Vargas, ... Annals of the new York Academy of Sciences 1147, 61, 2008 | 691 | 2008 |
Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes … AD Kraft, DA Johnson, JA Johnson Journal of Neuroscience 24 (5), 1101-1112, 2004 | 655 | 2004 |
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte PC Chen, MR Vargas, AK Pani, RJ Smeyne, DA Johnson, YW Kan, ... Proceedings of the National Academy of Sciences 106 (8), 2933-2938, 2009 | 651 | 2009 |
Nrf2, a multi-organ protector? JM Lee, J Li, DA Johnson, TD Stein, AD Kraft, MJ Calkins, RJ Jakel, ... The FASEB Journal 19 (9), 1061-1066, 2005 | 613 | 2005 |
Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis MR Vargas, DA Johnson, DW Sirkis, A Messing, JA Johnson Journal of Neuroscience 28 (50), 13574-13581, 2008 | 540 | 2008 |
Inhibition of 7, 12-dimethylbenz (a) anthracene-and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin AK Verma, JA Johnson, MN Gould, MA Tanner Cancer research 48 (20), 5754-5758, 1988 | 500 | 1988 |
The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease MJ Calkins, DA Johnson, JA Townsend, MR Vargas, JA Dowell, ... Antioxidants & redox signaling 11 (3), 497-508, 2009 | 487 | 2009 |
Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of … TD Stein, NJ Anders, C DeCarli, SL Chan, MP Mattson, JA Johnson Journal of Neuroscience 24 (35), 7707-7717, 2004 | 402 | 2004 |
NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons JM Lee, AY Shih, TH Murphy, JA Johnson Journal of Biological Chemistry 278 (39), 37948-37956, 2003 | 377 | 2003 |
Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell … TD Stein, JA Johnson Journal of Neuroscience 22 (17), 7380-7388, 2002 | 360 | 2002 |
Nrf2—a therapeutic target for the treatment of neurodegenerative diseases DA Johnson, JA Johnson Free Radical Biology and Medicine 88, 253-267, 2015 | 339 | 2015 |
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes MS Yates, M Tauchi, F Katsuoka, KC Flanders, KT Liby, T Honda, ... Molecular cancer therapeutics 6 (1), 154-162, 2007 | 331 | 2007 |
The Nrf2–ARE cytoprotective pathway in astrocytes MR Vargas, JA Johnson Expert reviews in molecular medicine 11, 2009 | 313 | 2009 |
Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases L Gan, JA Johnson Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (8 …, 2014 | 312 | 2014 |
Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription MJ Calkins, RJ Jakel, DA Johnson, K Chan, YW Kan, JA Johnson Proceedings of the National Academy of Sciences 102 (1), 244-249, 2005 | 302 | 2005 |
Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells JM Lee, JM Hanson, WA Chu, JA Johnson Journal of biological chemistry 276 (23), 20011-20016, 2001 | 295 | 2001 |
Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells J Li, D Johnson, M Calkins, L Wright, C Svendsen, J Johnson Toxicological Sciences 83 (2), 313-328, 2005 | 280 | 2005 |