Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage response. C Chumduri, RK Gurumurthy, PK Zadora, Y Mi, TF Meyer Cell Host Microbe 13 (6), 746–758, 2013 | 197 | 2013 |
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia C Chumduri, RK Gurumurthy, H Berger, O Dietrich, N Kumar, S Koster, ... Nature cell biology 23 (2), 184-197, 2021 | 75 | 2021 |
Subversion of host genome integrity by bacterial pathogens C Chumduri, RK Gurumurthy, R Zietlow, TF Meyer Nature reviews Molecular cell biology 17 (10), 659-673, 2016 | 75 | 2016 |
Organoids of the female reproductive tract C Chumduri, MY Turco Journal of molecular medicine 99 (4), 531-553, 2021 | 70 | 2021 |
Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma. A Müller, C Zang, C Chumduri, B Dörken, PT Daniel, CW Scholz International Journal of Cancer 133 (8), 1813-24, 2013 | 64 | 2013 |
Integrated phosphoproteome and transcriptome analysis reveals chlamydia-induced epithelial-to-mesenchymal transition in host cells PK Zadora, C Chumduri, K Imami, H Berger, Y Mi, M Selbach, TF Meyer, ... Cell Reports 26 (5), 1286-1302. e8, 2019 | 53 | 2019 |
Combined human genome-wide RNAi and metabolite analyses identify IMPDH as a host-directed target against Chlamydia infection M Rother, E Gonzalez, ART da Costa, L Wask, I Gravenstein, M Pardo, ... Cell host & microbe 23 (5), 661-671. e8, 2018 | 42 | 2018 |
Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming S Koster, RK Gurumurthy, N Kumar, PG Prakash, J Dhanraj, S Bayer, ... Nature Communications 13 (1), 1030, 2022 | 37 | 2022 |
Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling Y Mi, RK Gurumurthy, PK Zadora, TF Meyer, C Chumduri MBio 9 (6), 10.1128/mbio. 01465-18, 2018 | 22 | 2018 |
Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma. C Chumduri, B Gillissen, A Richter, A Richter, A Milojkovic, T Overkamp, ... Journal of Molecular Medicine 93 (5), 559-72, 2015 | 20 | 2015 |
Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection RK Gurumurthy, S Koster, N Kumar, TF Meyer, C Chumduri Nature Protocols 17 (7), 1658-1690, 2022 | 17 | 2022 |
Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development. RK Gurumurthy, C Chumduri, A Karlas, S Kimmig, E Gonzalez, N Machuy, ... Molecular Microbiology 94 (1), 186-201, 2014 | 16 | 2014 |
Pan-class I PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53 A Müller, B Gillissen, A Richter, A Richter, C Chumduri, PT Daniel, ... Cell death & disease 9 (3), 384, 2018 | 13 | 2018 |
Transition of Wnt signaling microenvironment delineates the squamo-columnar junction and emergence of squamous metaplasia of the cervix C Chumduri, RK Gurumurthy, H Berger, S Koster, V Brinkmann, U Klemm, ... BioRxiv, 443770, 2018 | 12 | 2018 |
p14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop. A Milojkovic, PG Hemmati, A Müer, T Overkamp, C Chumduri, RU Jänicke, ... International Journal of Cancer 133 (11), 2551-62, 2013 | 11 | 2013 |
Spatial organisation and homeostasis of epithelial lineages at the gastroesophageal junction is regulated by the divergent Wnt mucosal microenvironment N Kumar, RK Gurumurthy, PG Prakash, SM Kurian, C Wentland, ... bioRxiv, 2021.08. 05.455222, 2021 | 3 | 2021 |
Chlamydia coinfection inhibits HPV-induced safeguards of the cellular and genomic integrity in patient-derived ectocervical organoids S Koster, RK Gurumurthy, H Berger, M Drabkina, HJ Mollenkopf, ... bioRxiv, 2021.04. 15.439996, 2021 | 2 | 2021 |
γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids J Dong, D Holthaus, C Peters, S Koster, M Ehsani, A Quevedo-Olmos, ... Frontiers in Immunology 14, 1281646, 2023 | 1 | 2023 |
Spatial analysis of organ-wide RNA, protein expression, and lineage tracing in the female mouse reproductive tract RK Gurumurthy, N Kumar, C Chumduri STAR protocols 2 (4), 100969, 2021 | 1 | 2021 |
Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis N Kumar, PG Prakash, C Wentland, SM Kurian, G Jethva, V Brinkmann, ... Nature Communications 15 (1), 3064, 2024 | | 2024 |