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Rational use of plasma protein and tissue binding data in drug design: miniperspective X Liu, M Wright, CECA Hop Journal of medicinal chemistry 57 (20), 8238-8248, 2014 | 165 | 2014 |
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2 ML Quan, CD Ellis, AY Liauw, RS Alexander, RM Knabb, G Lam, ... Journal of medicinal chemistry 42 (15), 2760-2773, 1999 | 136 | 1999 |
Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants PYS Lam, CG Clark, R Li, DJP Pinto, MJ Orwat, RA Galemmo, JM Fevig, ... Journal of medicinal chemistry 46 (21), 4405-4418, 2003 | 120 | 2003 |
Isoxazolines and isoxazoles as factor Xa inhibitors JR Pruitt, DJ Pinto, MJ Estrella, LL Bostrom, RM Knabb, PC Wong, ... Bioorganic & medicinal chemistry letters 10 (8), 685-689, 2000 | 102 | 2000 |
Drug concentration asymmetry in tissues and plasma for small molecule–related therapeutic modalities D Zhang, CECA Hop, G Patilea-Vrana, G Gampa, HK Seneviratne, ... Drug Metabolism and Disposition 47 (10), 1122-1135, 2019 | 95 | 2019 |
Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent … JR Pruitt, DJP Pinto, RA Galemmo, RS Alexander, KA Rossi, BL Wells, ... Journal of medicinal chemistry 46 (25), 5298-5315, 2003 | 93 | 2003 |
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Nonsymmetric P2/P2 ‘cyclic urea HIV protease inhibitors. Structure− activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues GV De Lucca, UT Kim, J Liang, B Cordova, RM Klabe, S Garber, ... Journal of medicinal chemistry 41 (13), 2411-2423, 1998 | 77 | 1998 |
Nonpeptide factor Xa inhibitors III: effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits PC Wong, EJ Crain, CA Watson, AM Zaspel, MR Wright, PY Lam, ... Journal of Pharmacology and Experimental Therapeutics 303 (3), 993-1000, 2002 | 75 | 2002 |
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Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase GS Jones, F Yu, A Zeynalzadegan, J Hesselgesser, X Chen, J Chen, ... Antimicrobial agents and chemotherapy 53 (3), 1194-1203, 2009 | 68 | 2009 |
Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis PC Wong, EJ Crain, RM Knabb, RP Meade, ML Quan, CA Watson, ... Journal of Pharmacology and Experimental Therapeutics 295 (1), 212-218, 2000 | 65 | 2000 |
Antiinflammatory drug-induced small intestinal permeability: the rat is a suitable model NM Davies, MR Wright, F Jamali Pharmaceutical research 11, 1652-1656, 1994 | 59 | 1994 |
Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors JD Rodgers, PYS Lam, BL Johnson, H Wang, SS Ko, SP Seitz, GL Trainor, ... Chemistry & biology 5 (10), 597-608, 1998 | 51 | 1998 |
Improved high-performance liquid chromatographic assay method for the enantiomers of ibuprofen MR Wright, S Sattari, DR Brocks, F Jamali Journal of Chromatography B: Biomedical Sciences and Applications 583 (2 …, 1992 | 51 | 1992 |
Effect of the enantiomers of flurbiprofen, ibuprofen, and ketoprofen on intestinal permeability NM Davies, MR Wright, AS Russell, F Jamali Journal of pharmaceutical sciences 85 (11), 1170-1173, 1996 | 50 | 1996 |
Limited extent of stereochemical conversion of chiral non-steroidal anti-inflammatory drugs induced by derivatization methods employing ethyl chloroformate MR Wright, F Jamali Journal of Chromatography B: Biomedical Sciences and Applications 616 (1), 59-65, 1993 | 47 | 1993 |
Synthesis, antiviral activity and pharmacokinetics of P1/P1′ substituted 3-aminoindazole cyclic urea HIV protease inhibitors RF Kaltenbach III, M Patel, RE Waltermire, GD Harris, BRP Stone, ... Bioorganic & medicinal chemistry letters 13 (4), 605-608, 2003 | 45 | 2003 |
Nonbenzamidine tetrazole derivatives as factor Xa inhibitors ML Quan, CD Ellis, MY He, AY Liauw, FJ Woerner, RS Alexander, ... Bioorganic & medicinal chemistry letters 13 (3), 369-373, 2003 | 40 | 2003 |