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| Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing G Yu, M Nishimura, S Arawaka, D Levitan, L Zhang, A Tandon, YQ Song, ... Nature 407 (6800), 48-54, 2000 | 1293 | 2000 |
| Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695 MA Chishti, DS Yang, C Janus, AL Phinney, P Horne, J Pearson, ... Journal of Biological Chemistry 276 (24), 21562-21570, 2001 | 1210 | 2001 |
| Autophagy failure in Alzheimer's disease—locating the primary defect RA Nixon, DS Yang Neurobiology of disease 43 (1), 38-45, 2011 | 700 | 2011 |
| Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits DS Yang, P Stavrides, PS Mohan, S Kaushik, A Kumar, M Ohno, ... Brain 134 (1), 258-277, 2011 | 501 | 2011 |
| Neurodegenerative lysosomal disorders: a continuum from development to late age RA Nixon, DS Yang, JH Lee Autophagy 4 (5), 590-599, 2008 | 420 | 2008 |
| Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques JH Lee, DS Yang, CN Goulbourne, E Im, P Stavrides, A Pensalfini, ... Nature neuroscience 25 (6), 688-701, 2022 | 353 | 2022 |
| Modulating factors in amyloid-β fibril formation J McLaurin, DS Yang, CM Yip, PE Fraser Journal of Structural Biology 130 (2-3), 259-270, 2000 | 340 | 2000 |
| Manipulating the amyloid-β aggregation pathway with chemical chaperones DS Yang, CM Yip, THJ Huang, A Chakrabartty, PE Fraser Journal of Biological Chemistry 274 (46), 32970-32974, 1999 | 323 | 1999 |
| Structural studies of soluble oligomers of the Alzheimer β-amyloid peptide TH Huang, DS Yang, NP Plaskos, S Go, CM Yip, PE Fraser, ... Journal of molecular biology 297 (1), 73-87, 2000 | 258 | 2000 |
| Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease DS Yang, A Kumar, P Stavrides, J Peterson, CM Peterhoff, M Pawlik, ... The American journal of pathology 173 (3), 665-681, 2008 | 216 | 2008 |
| Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins DS Yang, A Tandon, F Chen, G Yu, H Yu, S Arawaka, H Hasegawa, ... Journal of Biological Chemistry 277 (31), 28135-28142, 2002 | 210 | 2002 |
| Autophagy and neuronal cell death in neurological disorders RA Nixon, DS Yang Cold Spring Harbor Perspectives in Biology 4 (10), 2012 | 204 | 2012 |
| Copper (II)-induced conformational changes and protease resistance in recombinant and cellular PrP effect of protein age and deamidation K Qin, DS Yang, Y Yang, MA Chishti, LJ Meng, HA Kretzschmar, CM Yip, ... Journal of Biological Chemistry 275 (25), 19121-19131, 2000 | 199 | 2000 |
| Examining the zinc binding site of the amyloid‐β peptide DS Yang, JA McLaurin, K Qin, D Westaway, PE Fraser European Journal of Biochemistry 267 (22), 6692-6698, 2000 | 149 | 2000 |
| Presenilin structure, function and role in Alzheimer disease PE Fraser, DS Yang, G Yu, L Lévesque, M Nishimura, S Arawaka, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1502 (1), 1-15, 2000 | 149 | 2000 |
| Characterization of the Binding of Amyloid‐β Peptide to Cell Culture‐Derived Native Apolipoprotein E2, E3, and E4 Isoforms and to Isoforms from Human Plasma DS Yang, JD Smith, Z Zhou, SE Gandy, RN Martins Journal of neurochemistry 68 (2), 721-725, 1997 | 145 | 1997 |
| Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner DS Yang, DH Small, U Seydel, JD Smith, J Hallmayer, SE Gandy, ... Neuroscience 90 (4), 1217-1226, 1999 | 142 | 1999 |
| Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression MV Rao, PS Mohan, CM Peterhoff, DS Yang, SD Schmidt, PH Stavrides, ... Journal of Neuroscience 28 (47), 12241-12254, 2008 | 139 | 2008 |
| Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits DS Yang, P Stavrides, M Saito, A Kumar, JA Rodriguez-Navarro, M Pawlik, ... Brain 137 (12), 3300-3318, 2014 | 124 | 2014 |
Ralph A NixonProfessor of Psychiatry and Cell Biology New York University在 nki.rfmh.org 的电子邮件经过验证
