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Melina Malinen
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Nanofibrillar cellulose hydrogel promotes three-dimensional liver cell culture
M Bhattacharya, MM Malinen, P Lauren, YR Lou, SW Kuisma, L Kanninen, ...
Journal of controlled release 164 (3), 291-298, 2012
4882012
Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels
MM Malinen, LK Kanninen, A Corlu, HM Isoniemi, YR Lou, ML Yliperttula, ...
Biomaterials 35 (19), 5110-5121, 2014
2302014
Modulation of cancer cell survival pathways using multivalent liposomal therapeutic antibody constructs
GNC Chiu, LA Edwards, AI Kapanen, MM Malinen, WH Dragowska, ...
Molecular cancer therapeutics 6 (3), 844-855, 2007
692007
Organic solute transporter OSTα/β is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury
MM Malinen, I Ali, J Bezencon, JJ Beaudoin, KLR Brouwer
American Journal of Physiology-Gastrointestinal and Liver Physiology 314 (5 …, 2018
542018
A critical assessment of in vitro tissue models for ADME and drug delivery
KS Vellonen, M Malinen, E Mannermaa, A Subrizi, E Toropainen, YR Lou, ...
Journal of Controlled Release 190, 94-114, 2014
542014
Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside
JJ Beaudoin, KLR Brouwer, MM Malinen
Pharmacology & therapeutics 211, 107542, 2020
462020
Peptide nanofiber hydrogel induces formation of bile canaliculi structures in three-dimensional hepatic cell culture
MM Malinen, H Palokangas, M Yliperttula, A Urtti
Tissue Engineering Part A 18 (23-24), 2418-2425, 2012
392012
Synthesis and cellular uptake of fluorescently labeled multivalent hyaluronan disaccharide conjugates of oligonucleotide phosphorothioates
M Karskela, P Virta, M Malinen, A Urtti, H Lönnberg
Bioconjugate chemistry 19 (12), 2549-2558, 2008
332008
Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix
LK Kanninen, P Porola, J Niklander, MM Malinen, A Corlu, ...
Experimental cell research 341 (2), 207-217, 2016
312016
Regulation of human pluripotent stem cell-derived hepatic cell phenotype by three-dimensional hydrogel models
S Toivonen, MM Malinen, J Küblbeck, A Petsalo, A Urtti, P Honkakoski, ...
Tissue Engineering Part A 22 (13-14), 971-984, 2016
302016
Pregnancy-related hormones increase nifedipine metabolism in human hepatocytes by inducing CYP3A4 expression
R Khatri, N Kulick, RJB Rementer, JK Fallon, C Sykes, AP Schauer, ...
Journal of pharmaceutical sciences 110 (1), 412-421, 2021
222021
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells
MM Malinen, K Ito, HE Kang, P Honkakoski, KLR Brouwer
European Journal of Pharmaceutical Sciences 130, 186-195, 2019
162019
Novel in vitro method reveals drugs that inhibit organic solute transporter alpha/beta (OSTα/β)
MM Malinen, A Kauttonen, JJ Beaudoin, N Sjöstedt, P Honkakoski, ...
Molecular pharmaceutics 16 (1), 238-246, 2018
162018
Multicellular dosimetric chain for molecular radiotherapy exemplified with dose simulations on 3D cell spheroids
V Reijonen, LK Kanninen, E Hippeläinen, YR Lou, E Salli, A Sofiev, ...
Physica Medica 40, 72-78, 2017
122017
Optimization of canalicular ABC transporter function in HuH-7 cells by modification of culture conditions
HE Kang, MM Malinen, C Saran, P Honkakoski, KLR Brouwer
Drug Metabolism and Disposition 47 (10), 1222-1230, 2019
92019
Breath figure templated semifluorinated block copolymers with tunable surface properties and binding capabilities
L Valtola, M Karesoja, H Tenhu, P Ihalainen, J Sarfraz, J Peltonen, ...
Journal of Applied Polymer Science 132 (1), 2015
82015
The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality
W Kiander, KS Vellonen, MM Malinen, M Gynther, M Hagström, ...
Pharmaceutical Research 38, 1663-1675, 2021
62021
Hepatic transporter alterations by nuclear receptor agonist T0901317 in sandwich-cultured human hepatocytes: proteomic analysis and PBPK modeling to evaluate drug-drug …
K Ito, N Sjöstedt, MM Malinen, C Guo, KLR Brouwer
Journal of Pharmacology and Experimental Therapeutics 373 (2), 261-268, 2020
22020
Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β)
WA Murphy, JJ Beaudoin, T Laitinen, N Sjöstedt, MM Malinen, H Ho, ...
Molecular Pharmacology 100 (6), 599-608, 2021
2021
Plant-derived nanofibrillar cellulose hydrogel for cell culture and chemical testing
M Yliperttula, A Urtti, YR Lou, M Malinen, P Laurén, L Kanninen, ...
US Patent App. 17/190,351, 2021
2021
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