The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups C Curtis, SP Shah, SF Chin, G Turashvili, OM Rueda, MJ Dunning, ... Nature 486 (7403), 346-352, 2012 | 6029 | 2012 |
SARS-CoV-2 B. 1.617. 2 Delta variant replication and immune evasion P Mlcochova, SA Kemp, MS Dhar, G Papa, B Meng, IATM Ferreira, R Datir, ... Nature 599 (7883), 114-119, 2021 | 1225 | 2021 |
Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation D Peric-Hupkes, W Meuleman, L Pagie, SWM Bruggeman, I Solovei, ... Molecular cell 38 (4), 603-613, 2010 | 1115 | 2010 |
Ensembl 2007 TJP Hubbard, BL Aken, K Beal, B Ballester, M Cáccamo, Y Chen, ... Nucleic acids research 35 (suppl_1), D610-D617, 2007 | 987 | 2007 |
Ensembl 2009 TJP Hubbard, BL Aken, S Ayling, B Ballester, K Beal, E Bragin, S Brent, ... Nucleic acids research 37 (suppl_1), D690-D697, 2009 | 953 | 2009 |
SARS-CoV-2 evolution during treatment of chronic infection SA Kemp, DA Collier, RP Datir, IATM Ferreira, S Gayed, A Jahun, ... Nature 592 (7853), 277-282, 2021 | 942 | 2021 |
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis TA Down, VK Rakyan, DJ Turner, P Flicek, H Li, E Kulesha, S Graef, ... Nature biotechnology 26 (7), 779-785, 2008 | 782 | 2008 |
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2 DA Collier, IATM Ferreira, P Kotagiri, RP Datir, EY Lim, E Touizer, B Meng, ... Nature 596 (7872), 417-422, 2021 | 641 | 2021 |
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity L Song, Z Zhang, LL Grasfeder, AP Boyle, PG Giresi, BK Lee, ... Genome research 21 (10), 1757-1767, 2011 | 628 | 2011 |
Ensembl 2008 P Flicek, BL Aken, K Beal, B Ballester, M Cáccamo, Y Chen, L Clarke, ... Nucleic acids research 36 (suppl_1), D707-D714, 2007 | 622 | 2007 |
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension L Long, ML Ormiston, X Yang, M Southwood, S Gräf, RD Machado, ... Nature medicine 21 (7), 777-785, 2015 | 489 | 2015 |
Ensembl 2006 E Birney, D Andrews, M Cáccamo, Y Chen, L Clarke, G Coates, T Cox, ... Nucleic acids research 34 (suppl_1), D556-D561, 2006 | 488 | 2006 |
Federated learning for predicting clinical outcomes in patients with COVID-19 I Dayan, HR Roth, A Zhong, A Harouni, A Gentili, AZ Abidin, A Liu, ... Nature medicine 27 (10), 1735-1743, 2021 | 483 | 2021 |
The shaping and functional consequences of the microRNA landscape in breast cancer H Dvinge, A Git, S Gräf, M Salmon-Divon, C Curtis, A Sottoriva, Y Zhao, ... Nature 497 (7449), 378-382, 2013 | 475 | 2013 |
Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling Y Yuan, H Failmezger, OM Rueda, HR Ali, S Gräf, SF Chin, RF Schwarz, ... Science translational medicine 4 (157), 157ra143-157ra143, 2012 | 466 | 2012 |
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs) VK Rakyan, TA Down, NP Thorne, P Flicek, E Kulesha, S Gräf, ... Genome research 18 (9), 1518-1529, 2008 | 430 | 2008 |
Comprehensive rare variant analysis via whole-genome sequencing to determine the molecular pathology of inherited retinal disease KJ Carss, G Arno, M Erwood, J Stephens, A Sanchis-Juan, S Hull, K Megy, ... The American Journal of Human Genetics 100 (1), 75-90, 2017 | 427 | 2017 |
Whole-genome sequencing of patients with rare diseases in a national health system E Turro, WJ Astle, K Megy, S Gräf, D Greene, O Shamardina, HL Allen, ... Nature 583 (7814), 96-102, 2020 | 413 | 2020 |
BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis JDW Evans, B Girerd, D Montani, XJ Wang, N Galiè, ED Austin, G Elliott, ... The lancet Respiratory medicine 4 (2), 129-137, 2016 | 396 | 2016 |
100,000 genomes pilot on rare-disease diagnosis in health care—preliminary report 100,000 Genomes Project Pilot Investigators New England Journal of Medicine 385 (20), 1868-1880, 2021 | 395 | 2021 |