| Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human … Y Koh, H Nakata, K Maeda, H Ogata, G Bilcer, T Devasamudram, ... Antimicrobial agents and chemotherapy 47 (10), 3123-3129, 2003 | 466 | 2003 |
| Model structure of decorin and implications for collagen fibrillogenesis IT Weber, RW Harrison, RV Iozzo Journal of Biological Chemistry 271 (50), 31767-31770, 1996 | 451 | 1996 |
| Phase problem in crystallography RW Harrison JOSA a 10 (5), 1046-1055, 1993 | 319 | 1993 |
| Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus. M Stoffel, PH Froguel, J Takeda, H Zouali, N Vionnet, S Nishi, IT Weber, ... Proceedings of the National Academy of Sciences 89 (16), 7698-7702, 1992 | 303 | 1992 |
| High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains Y Tie, PI Boross, YF Wang, L Gaddis, AK Hussain, S Leshchenko, ... Journal of molecular biology 338 (2), 341-352, 2004 | 278 | 2004 |
| Geometric criteria of hydrogen bonds in proteins and identification ofbifurcated'hydrogen bonds IY Torshin, IT Weber, RW Harrison Protein engineering 15 (5), 359-363, 2002 | 193 | 2002 |
| Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114 AY Kovalevsky, F Liu, S Leshchenko, AK Ghosh, JM Louis, RW Harrison, ... Journal of molecular biology 363 (1), 161-173, 2006 | 170 | 2006 |
| Structural and kinetic analysis of drug resistant mutants of HIV‐1 protease B Mahalingam, JM Louis, CC Reed, JM Adomat, J Krouse, YF Wang, ... European Journal of Biochemistry 263 (1), 238-244, 1999 | 168 | 1999 |
| Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M AY Kovalevsky, Y Tie, F Liu, PI Boross, YF Wang, S Leshchenko, ... Journal of medicinal chemistry 49 (4), 1379-1387, 2006 | 160 | 2006 |
| Amprenavir complexes with HIV‐1 protease and its drug‐resistant mutants altering hydrophobic clusters CH Shen, YF Wang, AY Kovalevsky, RW Harrison, IT Weber The FEBS journal 277 (18), 3699-3714, 2010 | 154 | 2010 |
| Improved K-means clustering algorithm for exploring local protein sequence motifs representing common structural property W Zhong, G Altun, R Harrison, PC Tai, Y Pan IEEE transactions on Nanobioscience 4 (3), 255-265, 2005 | 148 | 2005 |
| Structural implications of drug‐resistant mutants of HIV‐1 protease: High‐resolution crystal structures of the mutant protease/substrate analogue complexes B Mahalingam, JM Louis, J Hung, RW Harrison, IT Weber Proteins: Structure, Function, and Bioinformatics 43 (4), 455-464, 2001 | 148 | 2001 |
| Novel hybrid hierarchical-K-means clustering method (HK-means) for microarray analysis B Chen, PC Tai, R Harrison, Y Pan 2005 IEEE computational systems bioinformatics conference-workshops (CSBW'05 …, 2005 | 143 | 2005 |
| Improved protein secondary structure prediction using support vector machine with a new encoding scheme and an advanced tertiary classifier HJ Hu, Y Pan, R Harrison, PC Tai IEEE Transactions on NanoBioscience 3 (4), 265-271, 2004 | 119 | 2004 |
| Atomic resolution crystal structures of HIV‐1 protease and mutants V82A and I84V with saquinavir Y Tie, AY Kovalevsky, P Boross, YF Wang, AK Ghosh, J Tozser, ... Proteins: Structure, Function, and Bioinformatics 67 (1), 232-242, 2007 | 116 | 2007 |
| The influence of temperature on lysozyme crystals. Structure and dynamics of protein and water IV Kurinov, RW Harrison Acta Crystallographica Section D: Biological Crystallography 51 (1), 98-109, 1995 | 115 | 1995 |
| Stiffness and energy conservation in molecular dynamics: An improved integrator RW Harrison Journal of computational chemistry 14 (9), 1112-1122, 1993 | 109 | 1993 |
| Glucokinase: structural analysis of a protein involved in susceptibility to diabetes. SJ Pilkis, IT Weber, RW Harrison, GI Bell Journal of Biological Chemistry 269 (35), 21925-21928, 1994 | 108 | 1994 |
| Hydration water and bulk water in proteins have distinct properties in radial distributions calculated from 105 atomic resolution crystal structures X Chen, I Weber, RW Harrison The Journal of Physical Chemistry B 112 (38), 12073-12080, 2008 | 106 | 2008 |
| Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir F Liu, AY Kovalevsky, Y Tie, AK Ghosh, RW Harrison, IT Weber Journal of molecular biology 381 (1), 102-115, 2008 | 104 | 2008 |
Irene WeberGeorgia State University在 gsu.edu 的电子邮件经过验证
